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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2021-10-14</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2587</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Impact of Gut Microbiota on the Risk of Cardiometabolic Diseases Development</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние кишечной микробиоты на риск развития кардиометаболических заболеваний</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5294-4930</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>Л. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyeva</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильева Любовь Эдуардовна</p><p>Москва</p></bio><bio xml:lang="en"><p>Lyubov E. Vasilyeva</p><p>Moscow</p></bio><email xlink:type="simple">lubasavvina1996@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драпкина Оксана Михайловна</p><p>Москва, eLibrary SPIN 4456-1297</p></bio><bio xml:lang="en"><p>Oxana M. Drapkina</p><p>Moscow, eLibrary SPIN 4456-1297</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр терапии и профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>11</month><year>2021</year></pub-date><volume>17</volume><issue>5</issue><fpage>743</fpage><lpage>751</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Vasilyeva L.E., Drapkina O.M., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Васильева Л.Э., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Vasilyeva L.E., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2587">https://www.rpcardio.online/jour/article/view/2587</self-uri><abstract><p>Obesity is a multifactorial disease that leads to excessive adipose tissue accumulation, mainly visceral fat. Importance and prevalence of obesity has increased significantly in recent decades all over the world. Until now, the pandemic of obesity has been associated more to lifestyle changes: excessive eating and low physical activity. In recent years, special attention has been paid to studying of composition and functions of intestinal microbiota as major factor in development of obesity and related comorbidities, such as hypertension, cardiac ischemia, heart failure and others. It is proved that gut microbiota affects extraction, accumulation and consumption of energy derived from food, lipid metabolism and immune response. It is also revealed that composition of the microbiota is different in thin and obese people. Thus, study of the relationship between intestinal microbiota composition and risk factors for cardiovascular diseases, in particular obesity, is an actual task. The purpose of this review is analyzing of literature about assessment of relationship between composition and functions of intestinal microbiota in the diagnostics, prevention and treatment of obesity and cardiovascular diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Ожирение является многофакторным заболеванием, приводящим к избыточному накоплению жировой ткани, главным образом, висцерального жира. Значение и распространенность ожирения существенно возросли за последние десятилетия во всем мире. До настоящего времени пандемия ожирения была связана в большей степени с изменением образа жизни: избыточным потреблением пищи и снижением физической активности. В последние годы особое внимание уделяется изучению состава и функций кишечной микробиоты в качестве основного фактора развития ожирения и связанных с ним сопутствующих заболеваний, таких как артериальная гипертензия, ишемическая болезнь сердца, сердечная недостаточность и другие. Уже доказано, что микробиота кишечника влияет на извлечение, накопление и расход энергии, получаемый из пищи, липидный обмен и иммунный ответ. Также выявлено, что состав микробиоты отличается у худых и страдающих ожирением людей. Таким образом, изучение связи состава кишечной микробиоты и факторов риска сердечно-сосудистых заболеваний, в частности, ожирения, является актуальной задачей. Целью настоящего обзора является анализ литературы по оценке связи состава и функций кишечной микробиоты в диагностике и профилактике ожирения и сердечно-сосудистых заболеваний.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кишечная микробиота</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>ожирение</kwd><kwd>триметиламин-N-оксид</kwd><kwd>короткоцепочечные жирные кислоты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gut microbiota</kwd><kwd>cardiovascular diseases</kwd><kwd>obesity</kwd><kwd>trimethylamine-N-oxide</kwd><kwd>short-chain fatty acids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Go AS, Mozaffarian D, Roger VL, et al. American Heart Association Statistics Committee and Stroke Sta tistics Subcommittee. Executive summary: heart disease and stroke statistics—2014 update: a report from the American heart association. 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