rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2021-10-17rpcardio-2592Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИRelationship between Chemotherapy and Atrial Fibrillation: Clinical CaseВзаимосвязь между химиотерапией и фибрилляцией предсердий: клиническое наблюдениеhttps://orcid.org/0000-0002-5383-8355АвагимянА. А.AvagimyanA. A.

Авагимян Ашот Арманович

Ереван

 

Ashot A. Avagimyan

Yerevan

avagimyan.cardiology@mail.ruhttps://orcid.org/0000-0001-5357-1518МкртчянЛ. Г.MkrtchyanL. H.

Мкртчян Лусине Генриховна

Ереван

Lusine H. Mkrtchyan

Yerevan

https://orcid.org/0000-0001-6181-1358ГеворкянА. А.GevorkyanA. A.

Геворкян Астхик Артаваздовна

Ереван

Astgik A. Gevorkyan

Yerevan

https://orcid.org/0000-0001-5236-084XКонончукН. Б.KononchukN. B.

Конончук Наталья Борисовна

Минск

Natalia B. Kononchuk

https://orcid.org/0000-0001-7896-2080КактурскийЛ. В.KakturskiyL. V.

Кактурский Лев Владимирович

Москва

Lev V. Kakturskiy

Moscow

https://orcid.org/0000-0003-0471-8397ДжндоянЗ. Т.DjndoyanZ. T.

Джндоян Зинаида Титаловна

Ереван

Zinaida T. Djndoyan

Yerevan

Ереванский государственный медицинский университетАрменияYerevan State Medical University after M. HeratsiArmeniaМинская городская клиническая больница скорой медицинской помощиБеларусьMinsk City Clinical Hospital of Emergency CareBelarusНаучно-исследовательский институт морфологии человекаРоссияResearch Institute of Human MorphologyRussian Federation202103112021175785791Copyright © Avagimyan A.A., Mkrtchyan L.H., Gevorkyan A.A., Kononchuk N.B., Kakturskiy L.V., Djndoyan Z.T., 20212021Авагимян А.А., Мкртчян Л.Г., Геворкян А.А., Конончук Н.Б., Кактурский Л.В., Джндоян З.Т.Avagimyan A.A., Mkrtchyan L.H., Gevorkyan A.A., Kononchuk N.B., Kakturskiy L.V., Djndoyan Z.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2592

The aim of this article is to represent the characterization of the clinical case of chemotherapy-related atrial fibrillation (AF) development in the young woman, elaborated as a result of multiple neoadjuvant and adjuvant modes of the intake of chemotherapy (both anthracycline based and non-anthracycline ones). In this case, the noted disturbances of heart rhythm should be recognized as a manifestation of cardiotoxicity. The latter implies the degree of detrimental effect of chemotherapeutical medication on the morphophynctional parameters of the cardiovascular system. Anthracycline drugs, being highly effective chemotherapytical agents, provide well-known toxic effects on the heart and vessels. Anthracycline mediated cardiotoxicity is a well- known veracity that dates back to the 60s of the last century, but up to now this medication sustains irreplaceable components of big volume of chemotherapy modes. Moreover, it should be noted that relatively newer drugs also posses certain cardiotoxicogenic potential.

Цель данной статьи - описание клинического случая фибрилляции предсердий (ФП) на фоне приема множественных неоадъювантных и адъювантных режимов химиотерапии, содержащих препараты как антрациклинового ряда, так и других групп. В данном случае отмеченное нарушение ритма является проявлением кардиотоксичности. Последнее подразумевает степень деструктивного воздействия химиопрепарата на структурно-функциональные параметры сердечно-сосудистой системы. Необходимо отметить, что клиническая манифестация кардиотоксичности может быть как острой, т.е. проявиться непосредственно после введения химиопрепарата (часто при вынужденно высоких кумулятивных дозах), отсроченной, так и иметь поздний характер. Высокоэффективные препараты антрациклинового ряда, кардиотоксичность которых известна достаточно давно, продолжают оставаться практически незаменимыми компонентами многих режимов химиотерапии. Стоит отметить, что сравнительно более новые препараты также обладают кардиотоксическим действием.

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The authors declare that there are no conflicts of interest present.