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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2014-10-3-334-338</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-261</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>THE SAFETY OF STATINS: WHAT A PHYSICIAN NEEDS TO KNOW</article-title><trans-title-group xml:lang="ru"><trans-title>БЕЗОПАСНОСТЬ СТАТИНОВ: ЧТО НУЖНО ЗНАТЬ ПРАКТИКУЮЩЕМУ ВРАЧУ?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Напалков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Napalkov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры факультетской терапии № 1 лечебного факультета</p><p>119991, Москва, ул. Трубецкая, 8, стр.2</p></bio><bio xml:lang="en"><p>Trubetskaya ul. 8-2, Moscow, 119991 Russia</p></bio><email xlink:type="simple">dminap@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2015</year></pub-date><volume>10</volume><issue>3</issue><fpage>334</fpage><lpage>338</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Napalkov D.A., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Напалков Д.А.</copyright-holder><copyright-holder xml:lang="en">Napalkov D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/261">https://www.rpcardio.online/jour/article/view/261</self-uri><abstract><p>Various aspects of the safety of statins in clinical practice are discussed: hepatotoxicity, myopathy and rhabdomyolysis, the impact on the diabetes and cognitive dysfunction onset, renal function impairment.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются различные аспекты безопасности статинов в клинической практике: гепатотоксичность, миопатии и рабдомиолиз, развитие сахарного диабета и когнитивной дисфункции, а также нарушений функции почек.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>статины</kwd><kwd>гепатотоксичность</kwd><kwd>миопатии</kwd><kwd>сахарный диабет</kwd><kwd>когнитивная дисфункция</kwd><kwd>функция почек</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hepatotoxicity</kwd><kwd>myopathy</kwd><kwd>diabetes mellitus</kwd><kwd>cognitive dysfunction</kwd><kwd>renal function</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER). 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