rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2014-10-3-339-345rpcardio-262Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИOPTIMIZING THE TREATMENT OF PATIENTS WITH HYPERTENSION AND CORONARY HEART DISEASE WITH LERCANIDIPINEОПТИМИЗАЦИЯ ЛЕЧЕНИЯ ЛЕРКАНИДИПИНОМ ПАЦИЕНТОВ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ И ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦАТрисветоваЕ. Л.TrisvetovaE. L.

д.м.н., профессор, профессор 2-й кафедры внутренних болезней

Республика Беларусь, Минск, 220116, пр. Дзержинского, 83

Dzerzhinsky prosp. 83, Minsk, 220116 Republic of Belarus

trisvet-47@mail.ruБелорусский государственный медицинский университетБеларусьBelarusian State Medical UniversityBelarus201425092015103339345Copyright © Trisvetova E.L., 20152015Трисветова Е.Л.Trisvetova E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/262

Comorbidity of cardiovascular diseases reciprocally aggravates their course and induces the need to use safety and well-tolerated drugs. Pharmacological and pharmacokinetic properties of lercanidipine – the third-generation calcium channel blocker – are characterized by high lipophilicity and tissue selectivity. Clinical studies provide evidence of antihypertensive efficacy and safety of lercanidipine that is successfully used in patients with arterial hypertension and coronary heart disease.

Сочетание сердечно-сосудистых заболеваний взаимоотягощает их течение и обусловливает необходимость использования лекарственных препаратов с безопасным профилем и хорошей переносимостью. Описаны фармакологические и фармакокинетические особенности лерканидипина – блокатора кальциевых каналов третьего поколения, отличающегося высокой липофильностью и тканевой селективностью. Приведены клинические исследования, доказывающие антигипертензивную эффективность и безопасность лерканидипина, успешно применяемого у пациентов с артериальной гипертензией и ишемической болезнью сердца.

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The authors declare that there are no conflicts of interest present.