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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2021-12-17</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>Heterogeneity of abdominal obesity in patients with cardiovascular diseases</article-title><trans-title-group xml:lang="ru"><trans-title>Гетерогенность абдоминального ожирения у больных с сердечно-сосудистыми заболеваниями</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1009-099X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миклишанская</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Miklishanskaya</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миклишанская Софья Владимировна.</p><p>Москва.</p><p>eLibrary SPIN 2843-1855</p></bio><bio xml:lang="en"><p>Sofia V. Miklishanskaya.</p><p>Moscow.</p><p>eLibrary SPIN 2843-1855</p></bio><email xlink:type="simple">kvant83@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8362-6946</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соломасова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solomasova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соломасова Лилия Владимировна.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Lilia V. Solomasova.</p><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0794-4683</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орловский</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlovsky</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Орловский Алексей Александрович.</p><p>Москва.</p><p>eLibrary SPIN 9976-1620</p></bio><bio xml:lang="en"><p>Alexey A. Orlovsky.</p><p>Moscow.</p><p>eLibrary SPIN 9976-1620</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0920-7417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонова</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonova</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Насонова Светлана Николаевна.</p><p>Москва.</p><p>eLibrary SPIN 5423-0041</p></bio><bio xml:lang="en"><p>Svetlana N. Nasonova.</p><p>Moscow.</p><p>eLibrary SPIN 5423-0041</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0984-1562</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазур</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazur</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазур Николай Алексеевич.</p><p>Москва.</p><p>eLibrary SPIN 2391-0976</p></bio><bio xml:lang="en"><p>Nikolai A. Mazur.</p><p>Moscow.</p><p>eLibrary SPIN 2391-0976</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр кардиологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>12</day><month>01</month><year>2022</year></pub-date><volume>17</volume><issue>6</issue><fpage>867</fpage><lpage>872</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Miklishanskaya S.V., Solomasova L.V., Orlovsky A.A., Nasonova S.N., Mazur N.A., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Миклишанская С.В., Соломасова Л.В., Орловский А.А., Насонова С.Н., Мазур Н.А.</copyright-holder><copyright-holder xml:lang="en">Miklishanskaya S.V., Solomasova L.V., Orlovsky A.A., Nasonova S.N., Mazur N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2632">https://www.rpcardio.online/jour/article/view/2632</self-uri><abstract><sec><title>Aim</title><p>Aim: To assess the content of visceral adipose tissue (VAT) in patients with abdominal obesity and its relationship with metabolic disorders.</p></sec><sec><title>Material and methods</title><p>Material and methods. Patients with abdominal obesity (n=107) were included in the study. All participants had an assessment of anthropometric parameters (height, weight), calculation of body mass index (BMI), proportion of total adipose tissue and VAT (bioimpedance analyzer), high-density lipoprotein cholesterol (HDL-c) levels, triglycerides, fasting blood glucose, epicardial thickness adipose tissue (two-dimensional echocardiography).</p></sec><sec><title>Results</title><p>Results. The median share of VAT (bioimpedance method) was 13%. Patients with abdominal obesity are divided by VAT into 2 groups: ≥14% or ≤13%. Patients with VAT≥14% had significantly higher levels of triglycerides (1.76 [1.27; 2.38] mmol / L) and glucose (6.33 [5.78; 7.87] mmol / L), and below HDL-c levels (0.95 [0.85; 1.21] mmol / L) compared with patients with VAT≤13% (1.32 [1.02; 1.50], 5.59 [5, 11; 6.16] and 1.31 [1.07; 1.58] mmol / L, respectively; p&lt;0.001 for all three comparisons). A significant correlation was found between VAT and triglyceride, glucose and HDL-c levels (r=0.40; r=0.40; r=-0.31, respectively; p&lt;0.001).</p></sec><sec><title>Conclusion</title><p>Conclusion. Persons with abdominal obesity are heterogeneous in the proportion of VAT. The proportion of VAT above the median is associated with metabolic disorders that are significant for the development and progression of atherosclerosis. An increase in BMI in obese individuals is not associated with an increase in VAT and an increase in the severity of metabolic disorders.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Изучить содержание висцеральной жировой ткани (ВЖТ) у больных с абдоминальным ожирением и ее взаимосвязь с метаболическими нарушениями.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Из 152 обследованных больных выявлено 107 человек с абдоминальным ожирением. Всем участникам проводилась оценка антропометрических показателей (рост, вес), расчет индекса массы тела (ИМТ), доли общей жировой ткани и ВЖТ (при помощи биоимпедансного анализатора), уровней холестерина липопротеинов высокой плотности (ХС ЛВП), триглицеридов, глюкозы крови натощак, толщины эпикардиальной жировой ткани при (помощи двухмерной эхокардиографии).</p></sec><sec><title>Результаты</title><p>Результаты. Медиана содержания ВЖТ по данным метода биоимпедансного анализа среди всех обследованных больных составила 13%. На основании этого больные с абдоминальным ожирением были разделены по уровню содержания висцерального жира на 2 группы: выше медианы (≥14%) и ниже, равно медиане (≤13%). У больных с содержанием ВЖТ были выше медианы показатели триглицеридов (1,76[1,27;2,38] ммоль/л) и глюкозы (6,33 [5,78;7,87] ммоль/л), а ХС ЛВП (0,95 [0,85;1,21] ммоль/л) – ниже по сравнению с пациентами, у которых содержание ВЖТ было ниже медианы (1,32 [1,02;1,50], 5,59 [5,11;6,16] и 1,31 [1,07;1,58] ммоль/л соответственно (р&lt;0,001 для всех трех сравнений). Была выявлена значимая (р&lt;0,001) корреляция между ВЖТ и уровнями триглицеридов, глюкозы и ХС ЛВП (r=0,40; r=0,40; r=-0,31 соответственно).</p></sec><sec><title>Заключение</title><p>Заключение. Лица с абдоминальным ожирением являются гетерогенными по содержанию ВЖТ. При этом содержание ВЖТ выше медианы сопровождается значимыми для развития и прогрессирования атеросклероза метаболическими нарушениями. Нарастание ИМТ у лиц с ожирением не связано с нарастанием ВЖТ и увеличением тяжести метаболических нарушений.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>абдоминальное ожирение</kwd><kwd>биоимпедансный анализ</kwd><kwd>висцеральная жировая ткань</kwd><kwd>триглицериды</kwd><kwd>холестерин липопротеинов высокой плотности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>abdominal obesity</kwd><kwd>bioimpedance analysis</kwd><kwd>visceral</kwd><kwd>epicardial adipose tissue</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проведено при поддержке Национального медицинского исследовательского центра кардиологии.</funding-statement><funding-statement xml:lang="en">The study was performed with the support of the National Medical Research Center of Cardiology.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Powell-Wiley Т, Poirier P, Burke L, et al. 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