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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2014-10-2-220-230</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-27</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>KEY PATHOGENETIC ASPECTS AND CLINICAL RELEVANCE OF MECHANICAL DYSSYNCHRONY</article-title><trans-title-group xml:lang="ru"><trans-title>ОСНОВНЫЕ ПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ МЕХАНИЧЕСКОЙ ДИССИНХРОНИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ставцева</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stavtseva</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ставцева Юлия Вадимовна – аспирант кафедры пропедевтики внутренних болезней медицинского факультета</p></bio><email xlink:type="simple">y.stavtseva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виллевальде</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Villevalde</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виллевальде Светлана Вадимовна – доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней медицинского факультета</p></bio><email xlink:type="simple">y.stavtseva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свешников</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sveshnikov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Свешников Артем Валерьевич – кандидат медицинских наук,  заведующий отделением рентгено-хирургических методов диагностики и лечения нарушений ритма сердца</p></bio><email xlink:type="simple">y.stavtseva@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobalava</surname><given-names>J. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кобалава Жанна Давидовна – доктор медицинских наук, профессор, заведующая кафедрой пропедевтики внутренних болезней медицинского факультета</p></bio><email xlink:type="simple">y.stavtseva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Peoples' Friendship University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медико-хирургический центр им. Н.И. Пирогова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Center of Medicine and Surgery named after N.I. Pirogov, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>19</day><month>09</month><year>2015</year></pub-date><volume>10</volume><issue>2</issue><fpage>220</fpage><lpage>230</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Stavtseva Y.V., Villevalde S.V., Sveshnikov A.V., Kobalava J.D., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Ставцева Ю.В., Виллевальде С.В., Свешников А.В., Кобалава Ж.Д.</copyright-holder><copyright-holder xml:lang="en">Stavtseva Y.V., Villevalde S.V., Sveshnikov A.V., Kobalava J.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/27">https://www.rpcardio.online/jour/article/view/27</self-uri><abstract><p>Review of scientific evidences on contemporary concepts of the pathogenesis of mechanical dyssynchrony and its significance in patients with chronic heart failure is presented.</p></abstract><trans-abstract xml:lang="ru"><p>Приводится обзор научных данных, посвященных современным представлениям о патогенезе механической диссинхронии и ее значении у пациентов с хронической сердечной недостаточностью.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>механическая диссинхрония</kwd><kwd>хроническая сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mechanical dyssynchrony</kwd><kwd>chronic heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kass DA, Chen CH, Curry C, et al. 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