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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2022-04-06</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2710</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>The Influence of Multivessel Bypass Surgery on the Onset of Atrial Fibrillation in Elderly Patients</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние коронарного шунтирования на возникновение послеоперационной фибрилляции предсердий у пациентов пожилого возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9351-6177</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубаненко</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubanenko</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рубаненко Олеся Анатольевна</p><p>Самара</p></bio><bio xml:lang="en"><p>Olesya A. Rubanenko</p><p>Samara</p></bio><email xlink:type="simple">olesya.rubanenko@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3996-4689</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубаненко</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubanenko</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рубаненко Анатолий Олегович</p><p>Самара</p></bio><bio xml:lang="en"><p>Anatolii O. Rubanenko</p><p>Samara</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>05</month><year>2022</year></pub-date><volume>18</volume><issue>2</issue><fpage>160</fpage><lpage>164</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rubanenko O.A., Rubanenko A.O., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Рубаненко О.А., Рубаненко А.О.</copyright-holder><copyright-holder xml:lang="en">Rubanenko O.A., Rubanenko A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2710">https://www.rpcardio.online/jour/article/view/2710</self-uri><abstract><p>Aim. To study the factors associated with the development of postoperative atrial fibrillation (POAF) with single- or two- or more vascular bypass grafting in elderly patients with coronary heart disease.Methods. The study included 454 patients with coronary artery disease who underwent CABG. Patients were divided into 4 groups: 1 group – with single-vessel bypass, 2 group – with 2-vessels, 3 group – with 3-vessels and 4 group with 4-vessels bypass. During the observation period postoperative atrial fibrillation (POAF) occurred in 7.5% of patients in group 1, 18.4% in group 2, 17.5% in group 3 and 19.2% of patients in group 4. Since there were no significant differences in the incidence of POAF in patients with 2-4-vessels bypass grafting, these groups were combined for further analysis. 2 groups are allocated: Group I comprised patients with single-vessel bypass graft (79 patients, 76.0% of males, the average age of 65.0 [63.0;68.0] years), Group II – with 2-4-vessels bypass grafts (357 patients, 78.4% of males, the median age of 67.5 [64.5;69.0] years).Results. POAF occurred in 7.5% of patients in group I and in 18.4% of patients in group II (p=0.03) on the median 4.9 [1.2;8.7] day after coronary artery bypass graft. The multivariate regression analysis showed that indicators, associated with POAF development in patients undergoing CABG were the following: aortic cross-clamping time &gt;36 min (odds ratio [OR)]1.4; 95% confidence interval (CI) 1.1-2.8; p=0.030), time of ischemia &gt;19 min (OR 1.7; 95% CI 1.2-3.3; p=0.020), age &gt;65 years (OR 1.8; 95% CI 1,1-4,1; p=0.010), left atrium diameter &gt;39 mm (OR 2.9; 95% CI 1.5-5.4; p=0.005), left ventricular ejection fraction &lt;51% (OR 1.9; 95% CI 1.2-3.0; p=0.04).Conclusion. In our study, atrial fibrillation in the early postoperative period was more common in patients undergoing multivessel coronary bypass surgery. Indicators, significantly associated with POAF in patients undergoing Coronary artery bypass graft were aortic cross-clamping time &gt;36 minutes, time of ischemia &gt;19 minutes, age &gt;65 years, left atrium diameter &gt;39 mm and left ventricular ejection fraction &lt;51%.</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Изучить факторы, ассоциированные с развитием послеоперационной фибрилляции предсердий (ПОФП) при одно- или двух- и более сосудистом шунтировании у пациентов с ишемической болезнью сердца пожилого возраста.Материал и методы. Обследовано 454 пациента с ишемической болезнью сердца, подвергнувшихся коронарному шунтированию. Пациенты составили 4 группы: с одно- (1 группа), с двух- (2 группа), с трех- (3 группа) и с четырехсосудистым (4 группа) шунтированием соответственно. За период наблюдения послеоперационная фибрилляция предсердий (ПОФП) развилась у 7,5%, 18,4%, 17,5% и 19,2% пациентов в 1, 2, 3 и 4 группах соответственно. В дальнейшем произведено объединение групп с 2-4-х сосудистым шунтированием ввиду статистически незначимых различий между ними по частоте ПОФП: I группа – пациенты, которым выполнено однососудистое шунтирование (79 больных, 76,0% мужчин, медиана возраста 65,0 [63,0;68,0] лет), II группа – 2-4-x сосудистое шунтирование (357 больных, 78,4% мужчин, медиана возраста 67,5 [64,5;69,0] лет).Результаты. ПОФП была зарегистрирована в 7,5% случаев в I группе и в 18,4% случаев – во II группе (р=0,03), медиана ее появления – 4,9 [1,2;8,7] сут после КШ. По данным проведенного многофакторного анализа с возникновением ПОФП ассоциировалось время пережатия аорты &gt;36 мин (отношение шансов [ОШ] 1,4; 95% доверительный интервал [ДИ] 1,1-2,8; р=0,03), время ишемии миокарда &gt;19 мин (ОШ 1,7; 95% ДИ 1,2-3,3; р=0,02), возраст &gt;65 лет (ОШ 1,8; 95% ДИ 1,1-4,1; р=0,01), диаметр левого предсердия &gt;39 мм (ОШ 2,9; 95% ДИ 1,5-5,4; р=0,005), а также фракция выброса левого желудочка &lt;51% (ОШ 1,9; 95% ДИ 1,2-3,0; р=0,04).Заключение. Развитие ПОФП после проведения операции КШ чаще отмечалось у пациентов, перенесших многососудистое коронарное шунтирование. Показателями, ассоциированными с развитием данного нарушения ритма, являлись возраст пациентов &gt;65 лет, время пережатия аорты &gt;36 мин, время ишемии миокарда &gt;19 мин, диаметр левого предсердия &gt;39 мм и фракция выброса левого желудочка &lt;51%.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>коронарное шунтирование</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>пожилой возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>coronary artery bypass graft</kwd><kwd>coronary artery disease</kwd><kwd>elderly</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проведено при поддержке Самарского государственного медицинского университета.</funding-statement><funding-statement xml:lang="en">The study was performed with the support of the Samara State Medical University.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Saito A, Kumamaru H, Ono M, et al. 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