References

rpcardio

Rational Pharmacotherapy in Cardiology

Рациональная Фармакотерапия в Кардиологии

1819-64462225-3653

«SILICEA-POLIGRAF» LLC

10.20996/1819-6446-2022-04-09

rpcardio-2715

Research Article

POINT OF VIEW

ТОЧКА ЗРЕНИЯ

Hostility, Anger, Psycho-emotional Factors and Cardiovascular Disease

Враждебность, гнев, психоэмоциональные факторы и сердечно-сосудистые заболевания

https://orcid.org/0000-0001-6104-0135

Андреева

Г. Ф.

Andreeva

G. F.

Андреева Галия Фатиховна

Москва

Galiya F. Andreeva

Moscow

gandreeva@gnicpm.ru

https://orcid.org/0000-0001-5195-8997

Горбунов

В. М.

Gorbunov

V. M.

Горбунов Владимир Михайлович

Москва

Vladimir M. Gorbunov

Moscow

Национальный медицинский исследовательский центр терапии и профилактической медициныРоссияNational Medical Research Center for Therapy and Preventive MedicineRussian Federation

2022

06052022

182191199

2022

Андреева Г.Ф., Горбунов В.М.

Andreeva G.F., Gorbunov V.M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.rpcardio.online/jour/article/view/2715

The review presents the main aspects of the relationship between psychoemotional factors, hostility, anger and cardiovascular diseases. The first chapter describes the main historical stages in the study of this problem, starting from the Middle Ages and ending with fundamental research of the 19-20 centuries. In the second part, the authors demonstrated that hostility/anger are a risk factor for the CVD development and affect the prognosis and course of CVD (hypertension, ischemic heart disease, various cardiac arrhythmias, etc.). In the third chapter, there were studies that found that high rates of hostility/ anger reduced the effectiveness of cardiovascular therapy. In the fourth part, there are the main correlation mechanisms of negative emotions, hostility/anger and the cardiovascular system, carried out through the relationships with the activation of the hypothalamic-pituitary-adrenal, autonomic nervous system, platelet activation, with the changes in the risk factors characteristics etc. In the final chapter, the authors suggested prospects for further study of the problem, probably associated with the assessment of behavioral interventions, pharmacological or complex effects on the severity of hostility/anger to reduce CVD mortality in individuals with high rates of hostility / anger.

В обзоре изложены основные аспекты взаимосвязей психоэмоциональных факторов, враждебности, гнева и сердечно-сосудистых заболеваний (ССЗ). В первом разделе освещены основные исторические этапы изучения этой проблемы, начиная со средних веков и заканчивая фундаментальными исследованиями 19-20 века. Представлены исследования, в которых авторы показали, что враждебность/гнев являются фактором риска для развития некоторых ССЗ и, кроме того, влияют на прогноз и течение уже имеющихся ССЗ (артериальной гипертензии, ишемической болезни сердца, различных нарушений сердечного ритма и др.). В других главах были продемонстрированы исследования, в которых выявлено, что выраженная враждебность и гнев снижают эффективность кардиоваскулярной терапии, рассматривались основные механизмы ассоциаций враждебности/гнева и сердечно-сосудистой системы через взаимосвязи с активацией оси гипоталамус-гипофиз-надпочечники, вегетативной нервной системы, тромбоцитов и др. В заключительной главе авторы обобщают основные аспекты данной проблемы и прогнозируют перспективы дальнейших исследований в этой области, которые, вероятно, будут связаны с изучением фармакологического, поведенческого, комплексного воздействия на выраженность враждебности/гнева. с целью снижения уровней смертности от ССЗ у лиц с высокими показателями враждебности/гнева.

психоэмоциональные факторывраждебностьгневсердечно-сосудистые заболеванияартериальная гипертензия

psychoemotional factorshostilityangercardiovascular diseasearterial hypertension

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The authors declare that there are no conflicts of interest present.