rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2022-04-12rpcardio-2718Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИThe Use of Levosimendan for the Treatment of Heart Failure and its Potential Organoprotective EffectsПрименение левосимендана при лечении сердечной недостаточности, и его потенциальные органопротективные эффектыhttps://orcid.org/0000-0003-2769-3807ЛебедеваН. Б.LebedevaN. B.

Лебедева Наталия Борисовна

Кемерово

Natalia B. Lebedeva

Kemerovo

lebenb@mail.ruhttps://orcid.org/0000-0002-7471-786XЧесноковаЛ. Ю.ChesnokovaL. Yu.

Чеснокова Лариса Юрьевна

Кемерово

Larisa Yu. Chesnokova

Kemerovo

Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation202206052022182218224Copyright © Lebedeva N.B., Chesnokova L.Y., 20222022Лебедева Н.Б., Чеснокова Л.Ю.Lebedeva N.B., Chesnokova L.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2718

The review article is aimed at providing a recent update on the use of levosimendan, an inotropic drug in current use for the treatment of heart failure. The review discusses its mechanisms of action, main hemodynamic effects, clinical trials and obtained evidences that have formed the basis of the current guidelines on its use, as well as the latest clinical and experimental trials evaluating its organ-protective effects. Conclusion: levosimendan has a promising potential for treating heart failure, prescribed even in low doses, and may be regarded as a drug with cerebroprotective and possible nephroprotective effects, requiring further large randomized clinical trials.

Цель настоящего обзора – осветить современные аспекты применения левосимендана как последнего из вошедших в клиническую практику инотропных средств для лечения сердечной недостаточности. В обзоре рассматриваются механизмы действия, основные гемодинамические эффекты, базовые испытания левосимендана, которые легли в основу современных рекомендаций по его применению, а также последние клинические и экспериментальные исследования орагнопротективных эффектов препарата. Массив накопленных данных свидетельствует о том, что левосимендан обладает вероятным потенциалом в качестве средства для лечения сердечной недостаточности, в том числе, при низкодозовом и амбулаторном применении, а также дополнительными церебропротективными и нефропротективными возможностями, что требует подтверждения в крупномасштабных рандомизированных клинических исследованиях.

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The authors declare that there are no conflicts of interest present.