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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2022-06-07</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2758</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>Historical Aspects of the Use of Antiarrhythmic Drugs in Clinical Practice</article-title><trans-title-group xml:lang="ru"><trans-title>Исторические аспекты применения антиаритмических препаратов в клинической практике</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8874-4108</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дощицин</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Doshchitsin</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дощицин Владимир Леонидович</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir L. Doshchitsin</p></bio><email xlink:type="simple">vlad.dos@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9536-8307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарзиманова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarzimanova</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарзиманова Аида Ильгизовна - eLibrary SPIN 2685-4078</p><p>Москва</p></bio><bio xml:lang="en"><p>Aida I. Tarzimanova - eLibrary SPIN 2685-4078</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>06</day><month>07</month><year>2022</year></pub-date><volume>18</volume><issue>3</issue><fpage>350</fpage><lpage>358</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Doshchitsin V.L., Tarzimanova A.I., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Дощицин В.Л., Тарзиманова А.И.</copyright-holder><copyright-holder xml:lang="en">Doshchitsin V.L., Tarzimanova A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2758">https://www.rpcardio.online/jour/article/view/2758</self-uri><abstract><p>Heart rhythm disorders are one of the most urgent problems in cardiology. The first reports on the possibility of using drugs in the treatment of cardiac arrhythmias began to appear in the scientific literature from the middle of the 18th century. This pharmacotherapeutic direction has been developed since the second half of the 20th century, when new antiarrhythmic drugs began to be used in clinical practice. The introduction of new drugs and modern methods of treating arrhythmias into clinical practice has significantly improved the prognosis and quality of life of patients. Combination antiarrhythmic therapy, including antiarrhythmic drugs and radiofrequency ablation, seems to be the most promising and successful tactic for treating patients in the future. A historical review of the literature on the clinical use of antiarrhythmic drugs both in past years and at present is presented in the article.</p></abstract><trans-abstract xml:lang="ru"><p>Нарушения ритма сердца остаются одной из наиболее актуальных проблем в кардиологии. С середины XVIII века в научной литературе стали появляться первые сообщения о возможности применения лекарственных средств при лечении нарушений сердечного ритма. Это направление получило развитие со второй половины XX века, когда на практике стали использовать ряд новых антиаритмических средств. Появление новых лекарственных средств и современных методов лечения аритмий позволило значительно улучшить прогноз и качество жизни больных. Комбинированная антиаритмическая терапия в виде совместного назначения антиаритмических средств и проведения радиочастотной аблации представляется наиболее перспективной и успешной тактикой лечения пациентов в будущем. В данной работе представлен исторический обзор литературы, посвященной клиническому применению антиаритмических средств как в прошлые годы, так и в настоящее время.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>антиаритмические препараты</kwd><kwd>медикаментозное лечение аритмий сердца</kwd><kwd>исторические аспекты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antiarrhythmic drugs</kwd><kwd>drug treatment of cardiac arrhythmias</kwd><kwd>historical aspects</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Плетнев Д.Д. Экспериментальные исследования по вопросу о происхождении аритмий. Диссертация доктора медицины. Москва, 1906.</mixed-citation><mixed-citation xml:lang="en">Pletnev DD. Experimental research on the origin of arrhythmias. Dissertation of the Doctor of Medicine. 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