rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-2-177-182rpcardio-284Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИFIXED COMBINATION OF THE CALCIUM CHANNEL BLOCKER LERCANIDIPINE AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR ENALAPRIL: POSSIBILITY OF USAGEФИКСИРОВАННАЯ КОМБИНАЦИЯ АНТАГОНИСТА КАЛЬЦИЯ ЛЕРКАНИДИПИНА И ИНГИБИТОРА АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА ЭНАЛАПРИЛА: ВОЗМОЖНОСТИ ПРИМЕНЕНИЯОстроумоваО. Д.OstroumovaO. D.

Остроумова Ольга Дмитриевна — доктор медицинских наук, профессор кафедры факультетской терапии и профессиональных болезней МГМСУ им. А.И. Евдокимова; профессор кафедры клинической фармакологии и пропедевтики внутренних болезней Первого МГМУ им. И.М. Сеченова

ostroumova.olga@mail.ruКопченовИ. И.KopchenovI. I.

Копченов Иван Иванович — кандидат медицинских наук, доцент кафедры факультетской терапии и профессиональных болезней МГМСУ им. А.И. Евдокимова

ostroumova.olga@mail.ruМосковский государственный медико-стоматологический университет им. А.И. Евдокимова; Первый Московский медицинский университет им. И.М.СеченоваРоссияMoscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical UniversityRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияMoscow State University of Medicine and DentistryRussian Federation20132509201592177182Copyright © Ostroumova O.D., Kopchenov I.I., 20152015Остроумова О.Д., Копченов И.И.Ostroumova O.D., Kopchenov I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/284

Data on the updated approach to the choice of two-component antihypertensive combinations for different clinical situations are presented. Advantages and indications for combination of an angiotensin converting enzyme (ACE) inhibitor and dihydropyridine calcium antagonist are considered. Data on the efficacy and safety of the combination of calcium antagonist of the third generation, lercanidipine, and ACE inhibitor, enalapril, are presented.

Приведены данные о современном подходе к выбору двухкомпонентных антигипертензивных комбинаций в разных клинических ситуациях. Рассмотрены преимущества и показания к назначению комбинации ингибитора ангиотензинпревращающего фермента (АПФ) с дигидропиридиновым антагонистом кальция. Приведены данные литературы об эффективности и безопасности комбинации антагониста кальция третьего поколения лерканидипина с ингибитором АПФ эналаприлом.

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The authors declare that there are no conflicts of interest present.