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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2013-9-2-203-204</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-290</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM THE JACC</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИЗ JACC</subject></subj-group></article-categories><title-group><article-title>EFFECT OF CHOLESTEROL BLOOD LEVEL REDUCTION BEGINNING EARLY IN LIFE ON THE RISK OF ISCHEMIC HEART DISEASE</article-title><trans-title-group xml:lang="ru"><trans-title>ЭФФЕКТ СНИЖЕНИЯ ХОЛЕСТЕРИНЕМИИ, НАЧИНАЯ С РАННЕГО ВОЗРАСТА, НА РИСК ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Perova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Перова Наталья Владимировна — доктор медицинских наук, профессор, руководитель отдела изучения биохимических маркеров риска хронических неинфекционных заболеваний</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Centre for Preventive Medicine, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2015</year></pub-date><volume>9</volume><issue>2</issue><fpage>203</fpage><lpage>204</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Perova N.V., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Перова Н.В.</copyright-holder><copyright-holder xml:lang="en">Perova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/290">https://www.rpcardio.online/jour/article/view/290</self-uri><abstract><p>Comments to the paper B.A. Ference, et al. Effect  of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease. A Mendelian Randomization Analysis (translation is published in №1 2013:90-98)</p></abstract><trans-abstract xml:lang="ru"><p>Комментарий к статье B.A. Ference et al. Влияние длительного снижения холестерина липопротеинов низкой плотности, начатого в молодом возрасте, на риск развития ишемической болезни сердца. Менделевский рандомизированный анализ (перевод опубликован в №1 2013:90-98)</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 2003;290:2277–3.</mixed-citation><mixed-citation xml:lang="en">Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 2003;290:2277–3.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen J, Pertsemlidis A, Kotowski IK, et al. Low LDLcholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005;37: 161–.</mixed-citation><mixed-citation xml:lang="en">Cohen J, Pertsemlidis A, Kotowski IK, et al. Low LDLcholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005;37: 161–.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kathiresan S. A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. N Engl J Med 2008;358:2299–300.</mixed-citation><mixed-citation xml:lang="en">Kathiresan S. A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. N Engl J Med 2008;358:2299–300.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol 2012; 60:2631–.</mixed-citation><mixed-citation xml:lang="en">Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol 2012; 60:2631–.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010;376:1670–1.</mixed-citation><mixed-citation xml:lang="en">Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010;376:1670–1.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008;118:672–.</mixed-citation><mixed-citation xml:lang="en">Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008;118:672–.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Avis HJ, Hutten BA, Gagne C, et al. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. Jam Coll Cardiol 2010;55:1121–.</mixed-citation><mixed-citation xml:lang="en">Avis HJ, Hutten BA, Gagne C, et al. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. Jam Coll Cardiol 2010;55:1121–.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
