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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2023-2929</article-id><article-id custom-type="edn" pub-id-type="custom">JCEAVK</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2929</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Pulmonary hypertension and heart failure: alternative indexes of right ventricular-pulmonary artery coupling</article-title><trans-title-group xml:lang="ru"><trans-title>Легочная гипертензия и хроническая сердечная недостаточность: альтернативные индексы правожелудочково-артериального сопряжения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8302-6916</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мареева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mareyeva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мареева Варвара Андреевна - аспирант кафедры факультетской терапии им акад А.И. Нестерова</p><p>Москва</p></bio><bio xml:lang="en"><p>Varvara A.Mareyeva</p><p>Moscow</p></bio><email xlink:type="simple">m.varvara07@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7410-9784</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клименко</surname><given-names>A. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клименко Алеся Александровна - заведующая кафедрой факультетской терапии им акад А.И. Нестерова</p><p>Москва</p></bio><bio xml:lang="en"><p>Alesya A.Klimenko</p><p>Moscow</p></bio><email xlink:type="simple">aaklimenko@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4669-1006</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шостак Надежда Александровна - профессор кафедры факультетской терапии им акад А.И. Нестерова</p><p>Москва</p></bio><bio xml:lang="en"><p>Nadezhda A. Shostak</p><p>Moscow</p></bio><email xlink:type="simple">nshostak44@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава России; ООО «Европейский медицинский центр»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University; European Medical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2023</year></pub-date><volume>19</volume><issue>4</issue><fpage>398</fpage><lpage>402</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Mareyeva V.A., Klimenko A.A., Shostak N.A., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Мареева В.А., Клименко A.A., Шостак Н.А.</copyright-holder><copyright-holder xml:lang="en">Mareyeva V.A., Klimenko A.A., Shostak N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2929">https://www.rpcardio.online/jour/article/view/2929</self-uri><abstract><p>Pulmonary hypertension is a serious cardiovascular pathology, often complicating the course of heart failure (HF). Excessive pulmonary artery pressure increases right ventricular afterload and progressively leads to dysfunction, which is associated with adverse outcomes regardless of left ventricular ejection fraction. In this regard, more attention should be paid to determining the right ventricular condition. Currently, in order to assess the right heart function in patients with pulmonary hypertension and HF, the right ventricular (RV)-pulmonary arterial (PA) coupling, is increasingly being used. The conventional formula to calculate this parameter is the ratio of tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP). This index has proven to be a powerful predictor of adverse outcomes. But this calculation method has a number of limitations and can lead to errors. It is extremely important to exclude or minimize any possible inaccuracies during prognostic assessment, which is why new researches of alternative RV-PA calculation options have been recently published. Such things as problems that can occur during TAPSE and PASP evaluation, ways of modifying the assessment of right heart’s functioning in patients with pulmonary hypertension and heart failure have been addressed. The value of new RV-PA alternative «surrogate» indexes has been discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Легочная гипертензия — это тяжелая патология сердечно-сосудистой системы, нередко осложняющая течение хронической сердечной недостаточности (ХСН). Чрезмерное повышение давления в легочной артерии, увеличивает постнагрузку на правый желудочек и постепенно приводит к его дисфункции, что, как известно, связано с неблагоприятными исходами независимо от фракции выброса левого желудочка. В связи с этим, определению состояния правого желудочка важно уделять больше внимания. В настоящее время, с целью оценки функции правых отделов сердца, у пациентов с легочной гипертензией и ХСН, все чаще используется практичный эхокардиографический показатель — правожелудочково-артериальное сопряжение (ПЖАС). Классической формулой для вычисления этого параметра, является отношение амплитуды систолического движения кольца трикуспидального клапана к систолическому давлению в легочной артерии (TAPSE/СДЛА). Данный индекс, показал себя как мощный предиктор неблагоприятных исходов, при этом его компоненты доступны визуализации и просты при интерпретации. Но такой метод вычисления имеет ряд ограничений и может приводить к ошибкам. При оценке прогноза особенно важно исключить или минимизировать любые погрешности, именно поэтому сравнительно недавно стали появляться работы, посвященные поиску альтернативных вариантов вычисления ПЖАС. Рассмотрены трудности, с которыми можно столкнуться при визуализации TAPSE и СДЛА, способы модификации оценки правых отделов сердца у пациентов с легочной гипертензией и хронической сердечной недостаточностью. Обсуждена ценность альтернативных «суррогатных» индексов ПЖАС.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>легочная гипертензия</kwd><kwd>эхокардиография</kwd><kwd>правый желудочек</kwd><kwd>легочная артерия</kwd><kwd>сердечная недостаточность</kwd><kwd>прогноз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pulmonary hypertension</kwd><kwd>echocardiography</kwd><kwd>right ventricle</kwd><kwd>pulmonary artery</kwd><kwd>heart failure</kwd><kwd>prognosis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">РНИМУ им НИ Пирогова</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ghio S, Gavazzi A, Campana C, et al. Independent and Additive Prognostic Value of Right Ventricular Systolic Function and Pulmonary Artery Pressure in Patients With Chronic Heart Failure. J Am Coll Cardiol. 2001;37(1):183-8. DOI:10.1016/ s0735-1097(00)01102-5.</mixed-citation><mixed-citation xml:lang="en">Ghio S, Gavazzi A, Campana C, et al. Independent and Additive Prognostic Value of Right Ventricular Systolic Function and Pulmonary Artery Pressure in Patients With Chronic Heart Failure. J Am Coll Cardiol. 2001;37(1):183-8. DOI:10.1016/ s0735-1097(00)01102-5.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ghio S, Guazzi M, Scardovi AB, et al. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail. 2016;19(7):873-879. DOI:10.1002/ejhf.664.</mixed-citation><mixed-citation xml:lang="en">Ghio S, Guazzi M, Scardovi AB, et al. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail. 2016;19(7):873-879. DOI:10.1002/ejhf.664.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gorter TM, Hoendermis ES, van Veldhuisen DJ, et al. Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and metaanalysis. Eur J Heart Fail. 2016;18(12):1472-1487. DOI:10.1002/ejhf.630.</mixed-citation><mixed-citation xml:lang="en">Gorter TM, Hoendermis ES, van Veldhuisen DJ, et al. Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and metaanalysis. Eur J Heart Fail. 2016;18(12):1472-1487. DOI:10.1002/ejhf.630.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mohammed SF, Hussain I, AbouEzzeddine OF, et al. Right Ventricular Function in Heart Failure With Preserved Ejection Fraction. A Community-Based Study. Circulation. 2014;130(25):2310-2320. DOI:10.1161/CIRCULATIONAHA. 113.008461.</mixed-citation><mixed-citation xml:lang="en">Mohammed SF, Hussain I, AbouEzzeddine OF, et al. Right Ventricular Function in Heart Failure With Preserved Ejection Fraction. A Community-Based Study. Circulation. 2014;130(25):2310-2320. DOI:10.1161/CIRCULATIONAHA. 113.008461.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Benza R, Biederman R, Murali S, et al. Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension. J Am Coll Cardiol. 2008;52:1683-1692. DOI:10.1016/j.jacc.2008.08.033.</mixed-citation><mixed-citation xml:lang="en">Benza R, Biederman R, Murali S, et al. Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension. J Am Coll Cardiol. 2008;52:1683-1692. DOI:10.1016/j.jacc.2008.08.033.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Deaconu S, Deaconu A, Scarlatescu A, et al. Right ventricular-arterial coupling — A new perspective for right ventricle evaluation in heart failure patients undergoing cardiac resynchronization therapy. Echocardiography. 2021;38(7):1157-1164. DOI:10.1111/echo.15096.</mixed-citation><mixed-citation xml:lang="en">Deaconu S, Deaconu A, Scarlatescu A, et al. Right ventricular-arterial coupling — A new perspective for right ventricle evaluation in heart failure patients undergoing cardiac resynchronization therapy. Echocardiography. 2021;38(7):1157-1164. DOI:10.1111/echo.15096.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Guazzi M, Bandera F, Pelissero G, et al. Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physiol Heart Circ Physiol. 2013;305(9):1373-1381. DOI:10.1152/ajpheart.00157.2013.</mixed-citation><mixed-citation xml:lang="en">Guazzi M, Bandera F, Pelissero G, et al. Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physiol Heart Circ Physiol. 2013;305(9):1373-1381. DOI:10.1152/ajpheart.00157.2013.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Guazzi M, Dixon D, Labate V, et al. RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction Stratification of Clinical Phenotypes and Outcomes. JACC: Cardiovasc Imaging. 2017;10(10):1211-1221. DOI:10.1016/j.jcmg.2016.12.024.</mixed-citation><mixed-citation xml:lang="en">Guazzi M, Dixon D, Labate V, et al. RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction Stratification of Clinical Phenotypes and Outcomes. JACC: Cardiovasc Imaging. 2017;10(10):1211-1221. DOI:10.1016/j.jcmg.2016.12.024.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tello K, Axmann J, Ghofrani HA, et al. Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension. Int J Cardiol. 2018;266:229-235. DOI:10.1016/j. ijcard.2018.01.053.</mixed-citation><mixed-citation xml:lang="en">Tello K, Axmann J, Ghofrani HA, et al. Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension. Int J Cardiol. 2018;266:229-235. DOI:10.1016/j. ijcard.2018.01.053.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Humbert M, Kovacs G, Hoeper MM, et al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618-3731. DOI:10.1093/eurheartj/ehac237.</mixed-citation><mixed-citation xml:lang="en">Humbert M, Kovacs G, Hoeper MM, et al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618-3731. DOI:10.1093/eurheartj/ehac237.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Noordegraaf VA, Galiè N.The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev. 2011;20(122):243-53. DOI:10.1183/09059180.00006511.</mixed-citation><mixed-citation xml:lang="en">Noordegraaf VA, Galiè N.The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev. 2011;20(122):243-53. DOI:10.1183/09059180.00006511.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shalaby A, Voigt A, El-Saed A, Saba S.Usefulness of pulmonary artery pressure by echocardiography to predict outcome in patients receiving cardiac resynchronization therapy heart failure. Am J Cardiol. 2008;101(2):238-241. DOI:10.1016/j.amjcard.2007.07.064.</mixed-citation><mixed-citation xml:lang="en">Shalaby A, Voigt A, El-Saed A, Saba S.Usefulness of pulmonary artery pressure by echocardiography to predict outcome in patients receiving cardiac resynchronization therapy heart failure. Am J Cardiol. 2008;101(2):238-241. DOI:10.1016/j.amjcard.2007.07.064.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bursi F, McNallan SM, Redfield MM, et al. Pulmonary pressures and death in heart failure: a community study. J Am Coll Cardiol. 2012;59(3):222-231. DOI:10.1016/j. jacc.2011.06.076.</mixed-citation><mixed-citation xml:lang="en">Bursi F, McNallan SM, Redfield MM, et al. Pulmonary pressures and death in heart failure: a community study. J Am Coll Cardiol. 2012;59(3):222-231. DOI:10.1016/j. jacc.2011.06.076.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lam CS, Roger VL, Rodeheffer RJ, et al. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009;53(13):1119-1126. DOI:10.1016/j.jacc.2008.11.051.</mixed-citation><mixed-citation xml:lang="en">Lam CS, Roger VL, Rodeheffer RJ, et al. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009;53(13):1119-1126. DOI:10.1016/j.jacc.2008.11.051.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yock PG, Popp RL. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation. 1984;70(4):657-62. DOI:10.1161/01.cir.70.4.657.</mixed-citation><mixed-citation xml:lang="en">Yock PG, Popp RL. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation. 1984;70(4):657-62. DOI:10.1161/01.cir.70.4.657.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher MR, Forfia PR, Chamera E, et al. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med. 2009;179(7):615-21. DOI:10.1164/rccm.200811-1691OC.</mixed-citation><mixed-citation xml:lang="en">Fisher MR, Forfia PR, Chamera E, et al. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med. 2009;179(7):615-21. DOI:10.1164/rccm.200811-1691OC.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Rich JD, Shah SJ, Swamy RS, et al. Inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension: implications for clinical practice. Chest. 2011;139(5):988-993. DOI:10.1378/chest.10-1269.</mixed-citation><mixed-citation xml:lang="en">Rich JD, Shah SJ, Swamy RS, et al. Inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension: implications for clinical practice. Chest. 2011;139(5):988-993. DOI:10.1378/chest.10-1269.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Duwat A, Zogheib E, Guinot P, et al. The gray zone of the qualitative assessment of respiratory changes in inferior vena cava diameter in ICU patients. Crit Care. 2014;18(1):R14. DOI:10.1186/cc13693.</mixed-citation><mixed-citation xml:lang="en">Duwat A, Zogheib E, Guinot P, et al. The gray zone of the qualitative assessment of respiratory changes in inferior vena cava diameter in ICU patients. Crit Care. 2014;18(1):R14. DOI:10.1186/cc13693.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Brennan JM, Blair JE, Goonewardena S, et al. Reappraisal of the use of inferior vena cava for estimating right atrial pressure. J Am Soc Echocardiogr. 2007;20(7);857-861. DOI:10.1016/j.echo.2007.01.005.</mixed-citation><mixed-citation xml:lang="en">Brennan JM, Blair JE, Goonewardena S, et al. Reappraisal of the use of inferior vena cava for estimating right atrial pressure. J Am Soc Echocardiogr. 2007;20(7);857-861. DOI:10.1016/j.echo.2007.01.005.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685-713. DOI:10.1016/j.echo.2010.05.010</mixed-citation><mixed-citation xml:lang="en">Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685-713. DOI:10.1016/j.echo.2010.05.010</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lau EM, Manes A, Celermajer DS, Galiè N. Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. Eur Heart J. 2011;32(20):2489-2498. DOI:10.1093/eurheartj/ehr160.</mixed-citation><mixed-citation xml:lang="en">Lau EM, Manes A, Celermajer DS, Galiè N. Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. Eur Heart J. 2011;32(20):2489-2498. DOI:10.1093/eurheartj/ehr160.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Borgeson DD, Seward JB, Miller FAJr, et al. Frequency of Doppler measurable pulmonary artery pressures. J Am Soc Echocardiogr. 1996;9:832-837. DOI:10.1016/s0894-7317(96)90475-7.</mixed-citation><mixed-citation xml:lang="en">Borgeson DD, Seward JB, Miller FAJr, et al. Frequency of Doppler measurable pulmonary artery pressures. J Am Soc Echocardiogr. 1996;9:832-837. DOI:10.1016/s0894-7317(96)90475-7.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">O’Leary JM, Assad TR, Xu M, et al. Lack of a tricuspid regurgitation Doppler signal and pulmonary hypertension by invasive measurement. J Am Heart Assoc. 2018;7(13):e009362. DOI:10.1161/JAHA.118.009362.</mixed-citation><mixed-citation xml:lang="en">O’Leary JM, Assad TR, Xu M, et al. Lack of a tricuspid regurgitation Doppler signal and pulmonary hypertension by invasive measurement. J Am Heart Assoc. 2018;7(13):e009362. DOI:10.1161/JAHA.118.009362.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Vahanian A, Beyersdorf F, Praz F, et al.; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. DOI:10.1093/eurheartj/ehab395.</mixed-citation><mixed-citation xml:lang="en">Vahanian A, Beyersdorf F, Praz F, et al.; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. DOI:10.1093/eurheartj/ehab395.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fonseca GH, Souza R, Salemi VM, et al. Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease. Eur Respir J. 2012;39(1):112-118. DOI:10.1183/09031936.00134410.</mixed-citation><mixed-citation xml:lang="en">Fonseca GH, Souza R, Salemi VM, et al. Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease. Eur Respir J. 2012;39(1):112-118. DOI:10.1183/09031936.00134410.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Parent F, Bachir D, Inamo J, et al. A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med. 2011;365(1):44-53. DOI:10.1056/ NEJMoa1005565.</mixed-citation><mixed-citation xml:lang="en">Parent F, Bachir D, Inamo J, et al. A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med. 2011;365(1):44-53. DOI:10.1056/ NEJMoa1005565.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hsiao S-H, Lin S-K, Wang W-C, et al. Severe tricuspid regurgitation shows significant impact in the relationship among peak systolic tricuspid annular velocity, tricuspid annular plane systolic excursion, and right ventricular ejection fraction. J Am Soc Echocardiogr. 2006;19(7):902-10. DOI.org/10.1016/j. echo.2006.01.014.</mixed-citation><mixed-citation xml:lang="en">Hsiao S-H, Lin S-K, Wang W-C, et al. Severe tricuspid regurgitation shows significant impact in the relationship among peak systolic tricuspid annular velocity, tricuspid annular plane systolic excursion, and right ventricular ejection fraction. J Am Soc Echocardiogr. 2006;19(7):902-10. DOI.org/10.1016/j. echo.2006.01.014.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez-Candales A, Rajagopalan N, Saxena N, et al. Right ventricular systolic function is not the sole determinant of tricuspid annular motion. Am J Cardiol. 2006;98(7):973-977. DOI:10.1016/j.amjcard.2006.04.041.</mixed-citation><mixed-citation xml:lang="en">Lopez-Candales A, Rajagopalan N, Saxena N, et al. Right ventricular systolic function is not the sole determinant of tricuspid annular motion. Am J Cardiol. 2006;98(7):973-977. DOI:10.1016/j.amjcard.2006.04.041.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlicek M, Wahl A, Rutz T, et al. Right ventricular systolic function assessment: rank of echocardiographic methods vs. cardiac magnetic resonance imaging. Eur J Echocardiogr. 2011;12(11):871-80. DOI:10.1093/EJECHOCARD/JER138.</mixed-citation><mixed-citation xml:lang="en">Pavlicek M, Wahl A, Rutz T, et al. Right ventricular systolic function assessment: rank of echocardiographic methods vs. cardiac magnetic resonance imaging. Eur J Echocardiogr. 2011;12(11):871-80. DOI:10.1093/EJECHOCARD/JER138.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Surkova E, Cosyns B, Gerber B, et al. The dysfunctional right ventricle: the importance of multi-modality imaging. Eur Heart J Cardiovasc Imaging. 2022;23(7):885-97. DOI:10.1093/EHJCI/JEAC037.</mixed-citation><mixed-citation xml:lang="en">Surkova E, Cosyns B, Gerber B, et al. The dysfunctional right ventricle: the importance of multi-modality imaging. Eur Heart J Cardiovasc Imaging. 2022;23(7):885-97. DOI:10.1093/EHJCI/JEAC037.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Grothues F, Moon JC, Bellenger NG, et al. Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J. 2004;147(2):218-23. DOI:10.1016/j.ahj.2003.10.005.</mixed-citation><mixed-citation xml:lang="en">Grothues F, Moon JC, Bellenger NG, et al. Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J. 2004;147(2):218-23. DOI:10.1016/j.ahj.2003.10.005.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Addetia K, Lang RM. Decoding the right ventricle in 3 dimensions. JAMA Cardiol. 2018;3(10):910-1. DOI:10.1001/jamacardio.2018.2452.</mixed-citation><mixed-citation xml:lang="en">Addetia K, Lang RM. Decoding the right ventricle in 3 dimensions. JAMA Cardiol. 2018;3(10):910-1. DOI:10.1001/jamacardio.2018.2452.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ghio S, Mercurio V, Fortuni F, et al. A comprehensive echocardiographic method for risk stratification in pulmonary arterial hypertension. Eur Respir J. 2020;56(3):2000513. DOI:10.1183/13993003.00513-2020.</mixed-citation><mixed-citation xml:lang="en">Ghio S, Mercurio V, Fortuni F, et al. A comprehensive echocardiographic method for risk stratification in pulmonary arterial hypertension. Eur Respir J. 2020;56(3):2000513. DOI:10.1183/13993003.00513-2020.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pestelli G, Fiorencis A, Trevisan F, et al. New measures of right ventricle-pulmonary artery coupling in heart failure: An all-cause mortality echocardiographic study. Int J Cardiol. 2021;329:234-241. DOI:10.1016/j.ijcard.2020.12.057.</mixed-citation><mixed-citation xml:lang="en">Pestelli G, Fiorencis A, Trevisan F, et al. New measures of right ventricle-pulmonary artery coupling in heart failure: An all-cause mortality echocardiographic study. Int J Cardiol. 2021;329:234-241. DOI:10.1016/j.ijcard.2020.12.057.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;29(4):277-314. DOI:10.1093/ehjci/jew082.</mixed-citation><mixed-citation xml:lang="en">Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;29(4):277-314. DOI:10.1093/ehjci/jew082.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Edmonston DL, Rajagopal S, Wolf M. Echocardiography to Screen for Pulmonary Hypertension in CKD. Kidney Int Rep. 2020;5(12):2275-2283. DOI:10.1016/j. ekir.2020.09.033.</mixed-citation><mixed-citation xml:lang="en">Edmonston DL, Rajagopal S, Wolf M. Echocardiography to Screen for Pulmonary Hypertension in CKD. Kidney Int Rep. 2020;5(12):2275-2283. DOI:10.1016/j. ekir.2020.09.033.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Vicenzi M, Caravita S, Rota I, et al. The added value of right ventricular function normalized for afterload to improve risk stratification of patients with pulmonary arterial hypertension. PLoS One. 2022;17(5):e0265059. DOI:10.1371/ journal. pone.0265059.</mixed-citation><mixed-citation xml:lang="en">Vicenzi M, Caravita S, Rota I, et al. The added value of right ventricular function normalized for afterload to improve risk stratification of patients with pulmonary arterial hypertension. PLoS One. 2022;17(5):e0265059. DOI:10.1371/ journal. pone.0265059.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ciurzynski M, Kurnicka K, Lichodziejewska B, et al. Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE) — A novel parameter for stepwise echocardiographic risk stratification in normotensive patients with acute pulmonary embolism. Circ J. 2018;82(4):1179-85. DOI:10.1253/circj.CJ-17-0940.</mixed-citation><mixed-citation xml:lang="en">Ciurzynski M, Kurnicka K, Lichodziejewska B, et al. Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE) — A novel parameter for stepwise echocardiographic risk stratification in normotensive patients with acute pulmonary embolism. Circ J. 2018;82(4):1179-85. DOI:10.1253/circj.CJ-17-0940.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Koestenberger M, Avian A, Cantinotti M, et al. A novel echocardiographic approach indicates disease severity in pediatric pulmonary hypertension. Pediatr Int. 2020;0:1-3. DOI:10.1111/ped.14163.</mixed-citation><mixed-citation xml:lang="en">Koestenberger M, Avian A, Cantinotti M, et al. A novel echocardiographic approach indicates disease severity in pediatric pulmonary hypertension. Pediatr Int. 2020;0:1-3. DOI:10.1111/ped.14163.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y-C, Huang C-H, Tu Y-K. Pulmonary hypertension and pulmonary artery acceleration time: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2018;31(2);201-210. DOI:10.1016/j.echo.2017.10.016.</mixed-citation><mixed-citation xml:lang="en">Wang Y-C, Huang C-H, Tu Y-K. Pulmonary hypertension and pulmonary artery acceleration time: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2018;31(2);201-210. DOI:10.1016/j.echo.2017.10.016.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kitabatake A, Inoue M, Asao M, et al. Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation. 1983;68(2):302-9. DOI:10.1161/01.cir.68.2.302.</mixed-citation><mixed-citation xml:lang="en">Kitabatake A, Inoue M, Asao M, et al. Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation. 1983;68(2):302-9. DOI:10.1161/01.cir.68.2.302.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Yared K, Noseworthy P, Weyman AE, et al. Pulmonary Artery Acceleration Time Provides an Accurate Estimate of Systolic Pulmonary Arterial Pressure during Transthoracic Echocardiography. J Am Soc Echocardiogr. 2011;24(6):687-92. DOI:10.1016/j.echo.2011.03.008.</mixed-citation><mixed-citation xml:lang="en">Yared K, Noseworthy P, Weyman AE, et al. Pulmonary Artery Acceleration Time Provides an Accurate Estimate of Systolic Pulmonary Arterial Pressure during Transthoracic Echocardiography. J Am Soc Echocardiogr. 2011;24(6):687-92. DOI:10.1016/j.echo.2011.03.008.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Granstam SO, Bjorklund E, Wikstrom G, Roos MW. Use of echocardiographic pulmonary acceleration time and estimated vascular resistance for the evaluation of possible pulmonary hypertension. Cardiovasc Ultrasound. 2013;11:7. DOI:10.1186/1476-7120-11-7.</mixed-citation><mixed-citation xml:lang="en">Granstam SO, Bjorklund E, Wikstrom G, Roos MW. Use of echocardiographic pulmonary acceleration time and estimated vascular resistance for the evaluation of possible pulmonary hypertension. Cardiovasc Ultrasound. 2013;11:7. DOI:10.1186/1476-7120-11-7.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Levy PT, Patel MD, Groh G, et al. Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children. J Am Soc Echocardiogr. 2016;29(11):1056-65. DOI:10.1016/j.echo.2016.08.013.</mixed-citation><mixed-citation xml:lang="en">Levy PT, Patel MD, Groh G, et al. Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children. J Am Soc Echocardiogr. 2016;29(11):1056-65. DOI:10.1016/j.echo.2016.08.013.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Cowie B, Kluger R, Rex S, Missant C.The relationship between pulmonary artery acceleration time and mean pulmonary artery pressure in patients undergoing cardiac surgery: an observational study. Eur J Anaesthesiol. 2016;33(1):28-33. DOI:10.1097/EJA.0000000000000314.</mixed-citation><mixed-citation xml:lang="en">Cowie B, Kluger R, Rex S, Missant C.The relationship between pulmonary artery acceleration time and mean pulmonary artery pressure in patients undergoing cardiac surgery: an observational study. Eur J Anaesthesiol. 2016;33(1):28-33. DOI:10.1097/EJA.0000000000000314.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Dammassa V, Corradi F, Colombo CNJ, et al. Pulmonary artery acceleration time accuracy for systolic pulmonary artery pressure estimation in critically ill patients. Ultrasound J. 2022;14(1):26. DOI:10.1186/s13089-022-00276-4.</mixed-citation><mixed-citation xml:lang="en">Dammassa V, Corradi F, Colombo CNJ, et al. Pulmonary artery acceleration time accuracy for systolic pulmonary artery pressure estimation in critically ill patients. Ultrasound J. 2022;14(1):26. DOI:10.1186/s13089-022-00276-4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
