rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2024-3017NKJRAGrpcardio-3017Research ArticleORIGINAL STUDIESОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯComparative placebo-controlled study on the effect of dietary supplements containing omega-3 polyunsaturated fatty acids on hemodynamics and lipid metabolism in postmenopausal womenCравнительное плацебо- контролируемое исследование влияния биологически активной добавки к пище, содержащей омега-3 полиненасыщенные жирные кислоты, на показатели гемодинамики и липидного спектра у женщин в постменопаузеhttps://orcid.org/0000-0001-5938-8917НапалковД. А.NapalkovD. A.

Напалков Дмитрий Александрович

Москва

Dmitry A. Napalkov

Moscow

dminap@mail.ruhttps://orcid.org/0000-0001-5938-8917СоколоваА. А.SokolovaA. A.

Соколова Анастасия Андреевна

Москва

Anastasya A. Sokolova

Moscow

sokolovastasya2@gmail.comhttps://orcid.org/0000-0003-0160-6015КудрявцеваА. А.KudrjavtsevaA. A.

Кудрявцева Анна Александровна

Москва

Anna A. Kudrjavtseva

Moscow

Ankudr@bk.ruhttps://orcid.org/0000-0001-6753-1365СкрипкаА. И.SkripkaA. I.

Скрипка Алена Игоревна

Москва

Alena I. Skripka

Moscow

alenskripka@yandex.ruhttps://orcid.org/0009-0005-5362-214XЖиленкоА. В.ZhilenkoA. V.

Жиленко Анна Владимировна

Москва

Anna V. Zhilenko

Moscow

https://orcid.org/0000-0003-2766-087XКолпачковаЕ. В.KolpachkovaE. V.

Колпачкова Екатерина Владимировна

Москва

Ekaterina V. Kolpachkova

Moscow

ekkolpachok@gmail.comhttps://orcid.org/0009-0006-2173-4937ВарваринаД. К.VarvarinaD. K.

Варварина Дарья Константиновна

Москва

Daria K. Varvarina

Moscow

varvarina@inbox.ruПервый Московский государственный медицинский университет им. И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)I. M. Sechenov First Moscow State Medical University (Sechenov University)АО "Группа компаний "Медси",JSC "Medsi" Company Group"ООО "Тымлатский рыбокомбинат""Tymlatsky Fish Processing Plant LLC"202423042024202221226Copyright © Napalkov D.A., Sokolova A.A., Kudrjavtseva A.A., Skripka A.I., Zhilenko A.V., Kolpachkova E.V., Varvarina D.K., 20242024Напалков Д.А., Соколова А.А., Кудрявцева А.А., Скрипка А.И., Жиленко А.В., Колпачкова Е.В., Варварина Д.К.Napalkov D.A., Sokolova A.A., Kudrjavtseva A.A., Skripka A.I., Zhilenko A.V., Kolpachkova E.V., Varvarina D.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/3017Aim

Aim. To study the effect of dietary supplements containing omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) on the parameters of ambulatory blood pressure monitoring (ABPM), 24-hour electrocardiogram (HM-ECG), and lipid profile in postmenopausal women.

Material and methods

Material and methods. The study involved 95 postmenopausal women with a mean age of 55.9±6.0 years, without cardiovascular complications, type 2 diabetes mellitus and atrial fibrillation/flutter. The patients were divided into the main group (n=49; dietary supplement with Omega-3 PUFAs 1 g 2 times/day — content of Omega-3 PUFAs at least 30%) and the placebo group (n=46; taking capsules with vegetable oil). 17 (34.7%) patients from the main group and 18 (39.1%) patients from the placebo group took constant antihypertensive therapy, 7 (14.3%) of patients from the main group and 7 (15.2%) patients from the placebo group took constant lipid- lowering therapy. The patients did not undergo any adjustment of antihypertensive and lipid-l owering therapy during observation. The patients underwent 24-hour blood pressure and electrocardiogram monitoring, and a lipid profile evaluation at the initial visit and after 3 months.

Results

Results. It was statistically registered a significant decrease in average daily diastolic BP according to ABPM data by 1.8 mmHg. Art. (p=0.03), as well as the average daily heart rate according to HM-ECG data by 1.9 beats per minute (p=0.04) in the main group after 3 months. LDL levels tended to decrease (p=0.07) in the mail group. There were no statistically significant changes in the average daily systolic blood pressure according to ABPM, the number of supraventricular and ventricular heart rhythm disturbances, or the lipid profile (TC, LDL, triglycerides, HDL) in both groups.

Conclusion

Conclusion. The dietary supplements containing Omega-3 PUFAs in postmenopausal women significantly reduces the level of daily diastolic blood pressure and daily heart rate without significant effect on lipid profile.

Цель

Цель. Изучить влияние омега-3 полиненасыщенных жирных кислот (ПНЖК Омега-3) в виде биологически активной добавки к пище на параметры суточного мониторирования артериального давления (АД), холтеровского мониторирования электрокардиограммы и липидный профиль у женщин в постменопаузе.

Материал и методы

Материал и методы. В рандомизированое плацебо- контролируемое исследование включены 95 женщин в постменопаузе (возраст 55,9±6,0 лет), не имеющих сердечно-с осудистых осложнений, сахарного диабета 2 типа и фибрилляции/трепетания предсердий. Пациентки были разделены на основную группу (n=49; биологически активная добавка к пище ПНЖК Омега-3 1 г 2 р/сут. с содержанием ПЖК Омега-3 не менее 30%) и группу плацебо (n=46; прием капсул с растительным маслом). 17 (34,7%) пациенток из основной группы и 18 (39,1%) пациенток из группы плацебо принимали постоянную антигипертензивную терапию, 7 (14,3%) пациенток из основной группы и 7 (15,2%) пациенток из группы плацебо принимали постоянную гиполипидемическую терапию без коррекции за время наблюдения. Исходно и через 3 мес. были проведены суточное мониторирование АД, холтеровское мониторирование электрокардиограммы и оценка липидного профиля.

Результаты

Результаты. Через 3 мес. в основной группе было зарегистрировано статистически значимое снижение среднесуточного диастолического АД на 1,8 мм рт.ст. (р=0,030), а также среднесуточной частоты сердечных сокращений (ЧСС) по на 1,9 уд/мин (р=0,040). Уровень липопротеинов низкой плотности в основной группе имел тенденцию к снижению (р=0,07). Не было найдено статистически значимых изменений среднесуточного систолического АД, количества наджелудочковых и желудочковых нарушений сердечного ритма, а также параметров липидного профиля в обеих группах.

Заключение

Заключение. Биологически активная добавка к пище ПЖК Омега-3 у женщин в постменопаузе статистически значимо снизила уровень среднесуточного диастолического АД и среднесуточной ЧСС, без значимого влияния на липдный профиль.

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The authors declare that there are no conflicts of interest present.