rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-6-701-707rpcardio-302Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИTHE ROLE OF P-GLYCOPROTEIN IN RATIONAL PHARMACOTHERAPY IN CARDIOLOGYРОЛЬ ГЛИКОПРОТЕИНА-Р В РАЦИОНАЛЬНОЙ ФАРМАКОТЕРАПИИ В КАРДИОЛОГИИЩулькинА. ВShulkinA. V.

Кандидат медицинских наук, ассистент кафедры фармакологии с курсом фармации и фармакотерапии факультета дополнительного профессионального образования

alekseyshulkin@rambler.ruЯкушеваЕ. Н.YakushevaE. N.

Доктор медицинских наук, доцент, заведующая кафедрой фармакологии с курсом фармации и фармакотерапии факультета дополнительного профессионального образования

alekseyshulkin@rambler.ruПоповаН. М.PopovaN. M.

Кандидат медицинских наук, ассистент фармакологии с курсом фармации и фармакотерапии факультета дополнительного профессионального образования

alekseyshulkin@rambler.ruРязанский государственный медицинский университет имени академика И.П. Павлова, РязаньРоссияRyazan State Ivan Petrovich Pavlov Medical University, RyazanRussian Federation20132509201596701707Copyright © Shulkin A.V., Yakusheva E.N., Popova N.M., 20152015Щулькин А.В., Якушева Е.Н., Попова Н.М.Shulkin A.V., Yakusheva E.N., Popova N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/302

On the basis of the analysis of published data the role of P-glycoprotein, carrier protein, in rational pharmacotherapy in cardiology was shown on the example of its substrates – digoxin, antiplatelet agents and anticoagulants. Determination of C3435T polymorphism of multidrug resistance gene (MDR1), encoding P-glycoprotein, in pharmacotherapy with digoxin, antiplatelet drugs (clopidogrel tikagrelol, prasugrel) and anticoagulants (dabigatran etexilate, rivaroxaban, edoxaban) is not feasible in routine practice. Drug in- teractions have clinical implications for the efficacy and safety of pharmacotherapy in coadministration of these drugs with P-glycoprotein substrates, inducers and inhibitors.

На основе анализа данных литературы показана роль гликопротеина-P, белка-транспортера, в рациональной фармакотерапии в кардиологии на примере его субстратов – дигоксина, антитромбоцитарных препаратов и антикоагулянтов. Определение полиморфизма C3435T гена множественной лекарственной устойчивости (MDR1), кодирующего гликопротеин-Р, при проведении фармакотерапии дигоксином, антитромбоцитарными препаратами (клопидогрелом, тикагрелолом, прасугрелом) и антикоагулянтами (дабигатрана этексилатом, ривароксабаном, эдоксабаном) не является целесообразным в рутинной практике. Клиническое значение для эффективности и безопасности фармакотерапии имеют межлекарственные взаимодействия при совместном назначении указанных лекарственных средств с субстратами, индукторами и ингибиторами гликопротеина-P.

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The authors declare that there are no conflicts of interest present.