rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2014-10-6-672-678rpcardio-308Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ«MEMORIES OF FUTURE»: CHANGE IN VERAPAMIL SIGNIFICANCE IN THE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION«ВОСПОМИНАНИЯ О БУДУЩЕМ»: ИЗМЕНЕНИЕ РОЛИ ВЕРАПАМИЛА В ЛЕЧЕНИИ БОЛЬНЫХ С ИШЕМИЧЕСКОЙГиляревскийС. Р.GilyarevskiyS. R.

д.м.н., профессор кафедры клинической фармакологии и терапии

Barrikadnaya ul. 2/1, Moscow, 123995 Russia

sgilarevsky@rambler.ruРоссийская медицинская академия последипломного образованияРоссияRussian Medical Academy of Postgraduate EducationRussian Federation201426092015106672678Copyright © Gilyarevskiy S.R., 20152015Гиляревский С.Р.Gilyarevskiy S.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/308

The significance of verapamil in the treatment of patients with ischemic heart disease (IHD) and hypertension (HT) is considered. Data on the limited role of beta-blockers in the improvement of patient’s status in stable IHD, data about negative effect of heart rate (HR) reduction on the central aortic pressure, as well as the relationship between HR and risk of complications in the INVEST trial are presented. Verapamil therapy in patients with HT and IHD without heart failure/systolic dysfunction and/or recent myocardial infarction may have advantages due to achievement of the sufficient antiischemic effect with less HR reduction.

Рассматривается роль верапамила в лечении пациентов с ишемической болезнью сердца (ИБС) и артериальной гипертензией (АГ). Представлены данные об ограниченной роли β-адреноблокаторов в улучшении состояния больных со стабильным течением ИБС, данные об отрицательном влиянии снижения частоты сердечных сокращений (ЧСС) на центральное давление в аорте, а также о связи между ЧСС и риском развития осложнений в исследовании INVEST. При лечении больных АГ и ИБС в отсутствие сердечной недостаточности/систолической дисфункции и/или недавно перенесенного инфаркта миокарда использование верапамила может иметь преимущества в связи с достижением достаточного противоишемического эффекта при меньшем влиянии на ЧСС.

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The authors declare that there are no conflicts of interest present.