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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2025-3259</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-3259</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Associations of composite mental health assessment scales with cardiovascular diseases and mortality in population aged 55 years and older</article-title><trans-title-group xml:lang="ru"><trans-title>Ассоциации интегральных шкал оценки ментального здоровья с сердечно-сосудистыми заболеваниями и смертностью лиц 55 лет и старше</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9332-0622</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Имаева</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Imaeva</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Имаева Асия Эмвяровна</p><p>Москва</p></bio><bio xml:lang="en"><p>Asiia E. Imaeva</p><p>Moscow</p></bio><email xlink:type="simple">AImaeva@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9844-3122</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куценко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kutsenko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куценко Владимир Александрович</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir A. Kutsenko</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8058-1081</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Имаева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Imaeva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Имаева Наталия Александровна</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia A. Imaeva</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8011-2798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баланова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balanova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баланова Юлия Андреевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Yulia A. Balanova</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9624-9374</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капустина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapustina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капустина Анна Владимировна</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna V. Kapustina</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2087-6483</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шальнова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shalnova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шальнова Светлана Анатольевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana A. Shalnova</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драпкина Оксана Михайловна</p><p>Москва</p></bio><bio xml:lang="en"><p>Oksana M. Drapkina</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2026</year></pub-date><volume>21</volume><issue>6</issue><fpage>513</fpage><lpage>520</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Imaeva A.E., Kutsenko V.A., Imaeva N.A., Balanova Y.A., Kapustina A.V., Shalnova S.A., Drapkina O.M., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Имаева А.Э., Куценко В.А., Имаева Н.А., Баланова Ю.А., Капустина А.В., Шальнова С.А., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Imaeva A.E., Kutsenko V.A., Imaeva N.A., Balanova Y.A., Kapustina A.V., Shalnova S.A., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/3259">https://www.rpcardio.online/jour/article/view/3259</self-uri><abstract><sec><title>Aim</title><p>Aim. To develop new composite mental health assessment scales integrating indicators of psycho-emotional and cognitive functioning, and to analyze their associations with cardiovascular diseases (CVD) and mortality in population aged 55 and older.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study was conducted as part of the prospective cohort study «Stress, Aging, and Health in Russia» (SAHR). A total of 1876 individuals (898 men and 978 women) examined between 2007-2009 were included. Using principal component analysis with varimax rotation applied to 11 initial indicators (self-rated health, quality of life, perceived stress, depression, cognitive status, auditory-verbal memory, level of trust, locus of control, general support, coping strategies), five composite scales were formed: Psychological, Self-Rated Health, Cognitive, Social Adaptation, and Trust Level. Epidemiological diagnosis of arterial hypertension, acute cerebrovascular accident (stroke), coronary artery disease (CAD), and myocardial infarction (MI) was established based on questionnaire data and instrumental examination methods. The median follow-up period was 13 years, during which 559 men and 369 women died, including 296 and 196 from CVD, respectively. Associations of the scales with CVD were analyzed using logistic regression, while associations with all-cause and CVD mortality were analyzed using Cox regression, adjusted for risk factors and CVD.</p></sec><sec><title>Results</title><p>Results. In men, psychological and cognitive impairments, as well as poor self-rated health, were associated with the presence of stroke, MI, and CAD. In women, these indicators were associated only with stroke and MI (self-rated health). Regarding mortality, multivariate analysis showed that cognitive impairment and poor health according to the self-rated health scale significantly increased the risk of all-cause mortality, regardless of gender and after adjustment for socio-demographic and clinical indicators. Similar results were observed for CVD mortality. In women, problems with social adaptation were an additional risk factor for all-cause mortality</p></sec><sec><title>Conclusion</title><p>Conclusion. The developed composite mental health assessment scales were significantly associated with CVD and mortality in individuals 55 years and older. The Self-Rated Health and Cognitive Functioning scales have high predictive power for mortality risk in both genders, that highlights their importance in clinical practice for assessing overall health and prognosis.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Разработать новые интегральные шкалы оценки ментального здоровья, объединяющие показатели психоэмоционального и когнитивного функционирования, и проанализировать их ассоциации с сердечно-сосудистыми заболеваниями (ССЗ) и смертностью у лиц в возрасте 55 лет и старше.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Исследование проведено в рамках проспективного когортного исследования «Стресс, старение и здоровье в России» (SAHR). Всего включено 1876 человек (898 мужчин и 978 женщин), обследованных в 2007-2009 гг. С помощью метода главных компонент с варимакс-вращением из 11 исходных показателей (самооценка здоровья, качество жизни, воспринимаемый стресс, депрессия, когнитивный статус, слухоречевая память, степень доверия, локус контроля, общая поддержка, стратегии совладающего поведения) были сформированы пять интегральных шкал: психологическая, самооценки здоровья, когнитивная, социальной адаптации и уровня доверия. Эпидемиологический диагноз артериальной гипертонии, острого нарушения мозгового кровообращения, ишемической болезни сердца, инфаркта миокарда устанавливался по данным опросного и инструментального методов обследования. Медиана периода наблюдения составила 13 лет, в течение которого умерли 559 мужчин и 369 женщин, из них 296 и 196 – от ССЗ, соответственно. Анализ ассоциаций шкал с ССЗ проводился с помощью логистической регрессии, со смертностью от всех причин и ССЗ – с использованием регрессии Кокса с поправкой на факторы риска и ССЗ.</p></sec><sec><title>Результаты</title><p>Результаты. По результатам исследования у мужчин нарушения психологического и когнитивного функционирования, а также плохая самооценка здоровья были ассоциированы с наличием острого нарушения мозгового кровообращения, инфарктом миокарда и ишемической болезнью сердца, а у женщин только с инсультом и инфарктом миокарда (самооценка здоровья). В отношении смертности многофакторный анализ показал, что когнитивные нарушения и плохое здоровье по данным шкалы самооценки здоровья статистически значимо повышали риск смерти от всех причин, независимо от пола и после поправки на социально-демографические и клинические показатели. Аналогичная картина наблюдалась для смертности от ССЗ. У женщин дополнительным независимым фактором риска смерти от всех причин являлись проблемы с социальной адаптацией.</p></sec><sec><title>Заключение</title><p>Заключение. Разработанные интегральные шкалы ментального здоровья значимо ассоциируются с ССЗ и смертностью среди лиц старше 55 лет. Шкалы самооценки здоровья и когнитивного функционирования обладают высокой предсказательной способностью в отношении риска смерти для обоих полов, что подчеркивает их важность в клинической практике для оценки общего здоровья и прогноза.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ментальное здоровье</kwd><kwd>психические расстройства</kwd><kwd>когнитивные нарушения</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>смертность</kwd><kwd>пожилое население</kwd><kwd>старение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mental health</kwd><kwd>mental disorders</kwd><kwd>cognitive impairment</kwd><kwd>cardiovascular diseases</kwd><kwd>mortality</kwd><kwd>elderly population</kwd><kwd>aging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2019 Ageing Collaborators. 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