rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2015-11-5-522-528rpcardio-327Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯThe role of peptide hormones (adiponectin, leptin, insulin) in the pathogenesis of atherosclerosisРОЛЬ ПЕПТИДНЫХ ГОРМОНОВ (АДИПОНЕКТИН, ЛЕПТИН, ИНСУЛИН) В ПАТОГЕНЕЗЕ АТЕРОСКЛЕРОЗАСметневС. А.SmetnevS. A.

кардиолог, аспирант лаборатории молекулярной генетики ГНИЦ ПМ

МешковА. Н.MeshkovA. N.

к.м.н., руководитель лаборатории молекулярной генетики ГНИЦ ПМ

meshkov@lipidclinic.ruГосударственный научно-исследовательский центр профилактической медицины 101000, Москва, Петроверигский пер., 10РоссияState Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 RussiaRussian Federation201505112015115522528Copyright © Smetnev S.A., Meshkov A.N., 20152015Сметнев С.А., Мешков А.Н.Smetnev S.A., Meshkov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/327

Currently, cardiovascular diseases (CVD) remain the main problem in the world and in Russia in particular. The study of the causes and progression of atherosclerosis is a critical moment in the fight against CVD. Adipose tissue and processes that occur in it attracts attention in recent years. The important role of adipose tissue as an endocrine and immune organ is revealed as well as its participation in the development of the inflammatory process. This leads to the development of initial manifestations of atherosclerosis a precursor of many metabolic disorders and CVD. Particular attention causes adipokines regulatory peptide hormones in the adipose tissue, as well as insulin, due to its close relationship with the adipose tissue and especially with adiponectin and leptin. Recent data on the role of adiponectin, leptin and insulin in the pathogenesis of atherosclerosis in order to identify new potential targets among peptide hormones for the treatment of atherosclerosis are presented. 

В настоящее время сердечно-сосудистые заболевания (ССЗ) остаются основной проблемой в мире и в России, в частности. Изучение причин возникновения и прогрессирования атеросклероза является критически важным моментом в борьбе с ССЗ. В последнее время все большее внимание привлекает жировая ткань, и те процессы, которые происходят в ней. Выявлена важная роль жировой ткани как иммунного и эндокринного органа, и её большое участие в развитии воспалительного процесса. Последний приводит к развитию начальных проявлений атеросклероза – предшественника многих метаболических нарушений и ССЗ. Особое значение имеют адипокины – пептидные регуляторные гормоны, являющиеся компонентами жировой ткани, и инсулин, в связи с его тесным взаимодействием с жировой тканью и, особенно, с адипонектином и лептином. Представлены современные данные о роли адипонектина, лептина и инсулина в патогенезе атеросклероза с целью выявления новых потенциальных мишеней для лечения атеросклероза среди пептидных гормонов. 

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The authors declare that there are no conflicts of interest present.