rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2007-3-2-53-58rpcardio-412Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИOXIDATIVE STRESS AND POSSIBILITY TO CORRECT IT WITH ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN PATIENTS WITH MYOCARDIAL INFARCTION ASSOCIATED WITH DIABETES MELLITUS TYPE 2ОКСИДАТИВНЫЙ СТРЕСС И ВОЗМОЖНОСТИ ЕГО КОРРЕКЦИИ ИНГИБИТОРАМИ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА У БОЛЬНЫХ ИНФАРКТОМ МИОКАРДА В СОЧЕТАНИИ С САХАРНЫМ ДИАБЕТОМ 2 ТИПАЛексинаК. С.LexinaK. S.

Кафедра терапии и семейной медицины

Chair of therapy and family medicine

ТимофееваН. Ю.TimofeevaN. Y.

Кафедра терапии и семейной медицины

Chair of therapy and family medicine

ЗадионченкоВ. С.ZadionchenkoV. S.

Кафедра терапии и семейной медицины

Chair of therapy and family medicine

ШехянГ. Г.ShehianG. G.

Кафедра терапии и семейной медицины

Chair of therapy and family medicine

АлдушинаК. А.AldushinaK. A.

Кафедра терапии и семейной медицины

Chair of therapy and family medicine

Московский государственный медико-стоматологический университетРоссияMoscow State medico-stomatological UniversityRussian Federation200727122015325358Copyright © Lexina K.S., Timofeeva N.Y., Zadionchenko V.S., Shehian G.G., Aldushina K.A., 20152015Лексина К.С., Тимофеева Н.Ю., Задионченко В.С., Шехян Г.Г., Алдушина К.А.Lexina K.S., Timofeeva N.Y., Zadionchenko V.S., Shehian G.G., Aldushina K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/412

The review is devoted to the modern data about mechanisms of cardiovascular dysfunction in patients suffering diabetes mellitus type 2, especially to the role of oxidative stress. It is determined that oxidative stress is involved in the development of myocardial ischemia, reperfusion-syndrome, endothelial dysfunction and atherogenesis. There are data that angiotensin converting enzyme inhibitor, zofenopril, has both cardio- and vasoprotective activities as well as antioxidative effect. These features are rationales to use it in patients with ischemic heart disease and diabetes mellitus.

В обзоре освещены современные представления о механизмах нарушения функции сердечно-сосудистой системы у больных с сахарным диабетом 2 типа. Особое внимание уделено роли оксидативного стресса в развитии ишемии миокарда, реперфузионного синдрома, эндотелиальной дисфункции, атерогенеза. Приведены данные, указывающие, что современный ингибитор ангиотензинпревращающего фермента, зофеноприл, обладает не только высокой кардио- и вазопротективной активностью, но и дополнительными антиоксидантными свойствами, что позволяет использовать его у больных ишемической болезнью сердца и сахарным диабетом.

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The authors declare that there are no conflicts of interest present.