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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2012-8-1-75-80</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-419</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>BETA-BLOCKERS IN THE TREATMENT OF ARTERIAL HYPERTENSION: EVIDENCE BASED DATA AND REAL PRACTICE</article-title><trans-title-group xml:lang="ru"><trans-title>БЕТА-АДРЕНОБЛОКАТОРЫ В ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ: ДАННЫЕ ДОКАЗАТЕЛЬНОЙ МЕДИЦИНЫ И РЕАЛЬНАЯ ПРАКТИКА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Leonova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры клинической фармакологии РНИМУ им. Н.И. Пирогова</p></bio><email xlink:type="simple">anti23@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University named after N.I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2015</year></pub-date><volume>8</volume><issue>1</issue><fpage>75</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Leonova M.V., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Леонова М.В.</copyright-holder><copyright-holder xml:lang="en">Leonova M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/419">https://www.rpcardio.online/jour/article/view/419</self-uri><abstract><p>Data of the largest meta-analyzes of beta-blockers use in arterial hypertension is presented. The role of beta-blockers among other basic groups of antihypertensive drugs (thiazide diuretics, calcium channel blockers, ACE inhibitors) is evaluated. Special considerations of beta-blockers use in hypertensive patients with diabetes mellitus and chronic heart failure are discussed. Special attention is paid to bisoprolol.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены данные наиболее крупных мета-анализов применения бета-адреноблокаторов (БАБ) при артериальной гипертонии. Оценивается роль БАБ среди других основных групп антигипертензивных препаратов (тиазидные диуретики, антагонисты кальция, ингибиторы АПФ). Рассматриваются особенности применения БАБ при артериальной гипертонии в сочетании с сахарным диабетом и хронической сердечной недостаточностью. Особое внимание уделяется бисопрололу.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бета-адреноблокаторы</kwd><kwd>бисопролол</kwd><kwd>артериальная гипертония</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>сахарный диабет</kwd></kwd-group><kwd-group xml:lang="en"><kwd>beta-blockers</kwd><kwd>bisoprolol</kwd><kwd>arterial hypertension</kwd><kwd>chronic heart failure</kwd><kwd>diabetes mellitus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wright J.M., Musini V.M. First-line drugs for hypertension. Cohrane Database Syst Rev 2009;(3):</mixed-citation><mixed-citation xml:lang="en">Wright J.M., Musini V.M. First-line drugs for hypertension. 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