rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2012-8-1-95-102rpcardio-422Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИOMEGA-3 POLYUNSATURATED FATTY ACIDS IN THE TREATMENT OF PATIENTS WITH CARDIOVASCULAR DISEASESОМЕГА-3 ПОЛИНЕНАСЫЩЕННЫЕ ЖИРНЫЕ КИСЛОТЫ В ЛЕЧЕНИИ БОЛЬНЫХ С СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИГоворинА. В.GovorinA. V.

д.м.н., профессор, академик РАЕН, ректор ЧГМА

ФилёвА. П.FilevA. P.

д.м.н., профессор кафедры факультетской терапии ЧГМА

andfilev@mail.ruЧитинская медицинская академияРоссияChita Medical AcademyRussian Federation2012271220158195102Copyright © Govorin A.V., Filev A.P., 20152015Говорин А.В., Филёв А.П.Govorin A.V., Filev A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/422

For today there are convincing evidences of beneficial effect of ω-3 polyunsaturated fatty acids (PUFA) - eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids – in a number of cardiovascular diseases. Efficacy of ω-3 PUFA was confirmed by results of the large-scale clinical trials. Data on ω-3 PUFA efficacy in heart failure and cardiac arrhythmia were received, besides their well-known hypolipidemic effect. Low level of ω-3 PUFA biomarker , ω-3 index (content of EPA and DHA in erythrocytes), is considered as a risk factor of coronary heart disease as well as a risk factor of fatal arrhythmias. Use of standardized medicinal product with high content of EPA and DHA leads to the positive therapeutic effect in patients with different cardiovascular diseases.

К настоящему времени получены убедительные доказательства благоприятного влияния ω-3 полиненасыщенных жирных кислот (ПНЖК) - эйкозапентаеновой (ЭПК) и докозагексаеновой (ДГК) - на течение целого ряда сердечно-сосудистых заболеваний. Эффективность ω-3 ПНЖК подтверждена результатами крупномасштабных клинических исследований. К хорошо известным гиполипидемическим эффектам ω-3 ПНЖК получены результаты их эффективности у пациентов с сердечной недостаточностью, нарушениями сердечного ритма. Низкий уровень биомаркера ω-3 ПНЖК, ω-3 индекс (содержание ЭПК + ДГК в эритроцитах) в настоящее время рассматривается в качестве фактора риска не только ишемической болезни сердца, но и фатальных аритмий. Применение стандартизованного препарата с высоким содержанием ЭПК и ДГК приводит к положительному терапевтическому эффекту у пациентов с различными сердечно-сосудистыми заболеваниями.

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The authors declare that there are no conflicts of interest present.