<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2015-11-6-577-581</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-435</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>The first Russian register of patients with chronic heart failure and atrial fibrillation (RIF-CHF): study design</article-title><trans-title-group xml:lang="ru"><trans-title>ПЕРВЫЙ РОССИЙСКИЙ РЕГИСТР БОЛЬНЫХ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ И ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ (РИФ-ХСН): ДИЗАЙН ИССЛЕДОВАНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, руководитель отдела заболеваний миокарда и сердечной недостаточности РКНПК</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жиров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhirov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., в.н.с. того же отдела</p></bio><email xlink:type="simple">izhirov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант того же отдела</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осмоловская</surname><given-names>Ю. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Osmolovskaya</surname><given-names>Yu. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., н.с. того же отдела</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голицын</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Golitsyn</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, руководитель отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца РКНПК</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский кардиологический научно-производственный комплекс 121552, Москва, ул. 3-я Черепковская, 15а</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Cardiology Research and Production Complex. Tretya Cherepkovskaya ul. 15a, Moscow, 121552 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>11</volume><issue>6</issue><fpage>577</fpage><lpage>581</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Tereshchenko S.N., Zhirov I.V., Romanova N.V., Osmolovskaya Y.F., Golitsyn S.P., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Терещенко С.Н., Жиров И.В., Романова Н.В., Осмоловская Ю.Ф., Голицын С.П.</copyright-holder><copyright-holder xml:lang="en">Tereshchenko S.N., Zhirov I.V., Romanova N.V., Osmolovskaya Y.F., Golitsyn S.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/435">https://www.rpcardio.online/jour/article/view/435</self-uri><abstract><p>Chronic heart failure (CHF) and atrial fibrillation (AF) can rightly be called the epidemic of the XXI century, which are associated with high morbidity and mortality of patients. Common risk factors and pathophysiological mechanisms explain the frequent combination of CHF and AF. So far, a number of issues related to management of these patients, remains unresolved. Data on compliance with clinical guidelines and the prevalence of long-term anticoagulant therapy in this group of patients in our country is limited. The first Russian register of CHF and AF (RIF-CHF) is initiated in order to better address this problem. The results allow to develop the most rational therapeutic and diagnostic strategies and, ultimately, to improve the clinical outcomes of such severe patients.</p></abstract><trans-abstract xml:lang="ru"><p>Хроническую сердечную недостаточность (ХСН) и фибрилляцию предсердий (ФП) по праву можно назвать эпидемиями XXI века, которые ассоциируются с высокой заболеваемостью и смертностью пациентов. Общие факторы риска и патофизиологические механизмы объясняют частое сочетание ХСН и ФП. До настоящего времени целый ряд вопросов, касающихся тактики ведения этой группы пациентов, остается нерешенным. Данные о соблюдении клинических рекомендаций и распространенности длительной антикоагулянтной терапии у данной группы больных в нашей стране ограничены. Для возможно более полного решения данной проблемы инициирован первый Российский регистр по проблеме ХСН и ФП (РИФ-ХСН). Полученные результаты позволят выработать наиболее рациональную лечебно-диагностическую стратегию и, в конечном итоге, улучшить клинические исходы столь тяжелой категории больных.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>фибрилляция предсердий</kwd><kwd>регистр больных</kwd><kwd>дизайн исследования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>atrial fibrillation</kwd><kwd>register of patients</kwd><kwd>study design</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ageev FT, Danielyan MO, Mareev VY et al. Patients with chronic heart failure in the Russian ambulatory practice: contingent features, diagnosis and treatment (studies of AGE-O-CHF). Serdechnaya Nedostatochnost' 2004; 5 (1): 4-7. In Russian (Агеев Ф.Т., Даниелян М.О., Мареев В.Ю. и др. Больные с хронической сердечной недостаточностью в российской амбулаторной практике: особенности контингента, диагностики и лечения (по материалам исследования ЭПОХА-О-ХСН). Сердечная Недостаточность 2004;5 (1):4-7).</mixed-citation><mixed-citation xml:lang="en">Ageev FT, Danielyan MO, Mareev VY et al. Patients with chronic heart failure in the Russian ambulatory practice: contingent features, diagnosis and treatment (studies of AGE-O-CHF). Serdechnaya Nedostatochnost' 2004; 5 (1): 4-7. In Russian (Агеев Ф.Т., Даниелян М.О., Мареев В.Ю. и др. Больные с хронической сердечной недостаточностью в российской амбулаторной практике: особенности контингента, диагностики и лечения (по материалам исследования ЭПОХА-О-ХСН). Сердечная Недостаточность 2004;5 (1):4-7).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ageev FT, Belenkov Yu, Fomin IV et al. Prevalence of chronic heart failure v Evropeyskoy part of the Russian Federation - Data AGE-CHF. Serdechnaya Nedostatochnost' 2006; 7 (1): 112-5. In Russian (Агеев Ф.Т., Беленков Ю.Н., Фомин И.В. и др. Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации – данные ЭПОХА-ХСН. Сердечная Недостаточность 2006;7 (1): 112-5).</mixed-citation><mixed-citation xml:lang="en">Ageev FT, Belenkov Yu, Fomin IV et al. Prevalence of chronic heart failure v Evropeyskoy part of the Russian Federation - Data AGE-CHF. Serdechnaya Nedostatochnost' 2006; 7 (1): 112-5. In Russian (Агеев Ф.Т., Беленков Ю.Н., Фомин И.В. и др. Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации – данные ЭПОХА-ХСН. Сердечная Недостаточность 2006;7 (1): 112-5).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fomin IV. Arterial hypertension in the Russian Federation - the past 10 years. What's next? Serdtse 2007; 6 (3): 1-6. In Russian (Фомин И.В. Артериальная гипертония в Российской Федерации – последние 10 лет. Что дальше? Сердце 2007;6 (3):1-6).</mixed-citation><mixed-citation xml:lang="en">Fomin IV. Arterial hypertension in the Russian Federation - the past 10 years. What's next? Serdtse 2007; 6 (3): 1-6. In Russian (Фомин И.В. Артериальная гипертония в Российской Федерации – последние 10 лет. Что дальше? Сердце 2007;6 (3):1-6).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bleumink G., Knetsch A., Sturkenboom M. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure: the Rotterdam Study. Eur Heart J 2004;25:1614-9.</mixed-citation><mixed-citation xml:lang="en">Bleumink G., Knetsch A., Sturkenboom M. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure: the Rotterdam Study. Eur Heart J 2004;25:1614-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ho K., Pinsky J., Kannel W., Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll- Cardiol 1993;22:6A-13A.</mixed-citation><mixed-citation xml:lang="en">Ho K., Pinsky J., Kannel W., Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll- Cardiol 1993;22:6A-13A.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mareev VY, Danielyan MO, Belenkov YN; On behalf of the working group study AGE-O-CHF. Comparative characteristics of patients with CHF, depending on the size of the PV on the results of the Russian multicenter study AGE-O-CHF. Serdechnaya Nedostatochnost' 2006; 7 (4): 164-71. In Russian (Мареев В.Ю., Даниелян М.О., Беленков Ю.Н. От имени рабочей группы исследования ЭПОХА-О-ХСН. Сравнительная характеристика больных с ХСН в зависимости от величины ФВ по результатам Российского многоцентрового исследования ЭПОХА-О-ХСН. Сердечная Недостаточность 2006;7 (4):164-71).</mixed-citation><mixed-citation xml:lang="en">Mareev VY, Danielyan MO, Belenkov YN; On behalf of the working group study AGE-O-CHF. Comparative characteristics of patients with CHF, depending on the size of the PV on the results of the Russian multicenter study AGE-O-CHF. Serdechnaya Nedostatochnost' 2006; 7 (4): 164-71. In Russian (Мареев В.Ю., Даниелян М.О., Беленков Ю.Н. От имени рабочей группы исследования ЭПОХА-О-ХСН. Сравнительная характеристика больных с ХСН в зависимости от величины ФВ по результатам Российского многоцентрового исследования ЭПОХА-О-ХСН. Сердечная Недостаточность 2006;7 (4):164-71).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng RK, Cox M, Neely ML, et al. Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population. Am Heart J 2014;168 (5):721-30.</mixed-citation><mixed-citation xml:lang="en">Cheng RK, Cox M, Neely ML, et al. Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population. Am Heart J 2014;168 (5):721-30.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992;327:685-91.</mixed-citation><mixed-citation xml:lang="en">The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992;327:685-91.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429-35.</mixed-citation><mixed-citation xml:lang="en">CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429-35.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wang T.J., Larson M.G., Levy D. et al. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation 2003;107:2920— 5.</mixed-citation><mixed-citation xml:lang="en">Wang T.J., Larson M.G., Levy D. et al. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation 2003;107:2920— 5.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nieuwlaat R, Capucci A, Camm AJ, et al. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation. EurHeart J 2005;26:2422-34.</mixed-citation><mixed-citation xml:lang="en">Nieuwlaat R, Capucci A, Camm AJ, et al. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation. EurHeart J 2005;26:2422-34.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cleland JG, Swedberg K, Follath F, et al. The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J 2003;24:442-63.</mixed-citation><mixed-citation xml:lang="en">Cleland JG, Swedberg K, Follath F, et al. The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J 2003;24:442-63.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Khan MA, Ahmed F, Neyses L, Mamas MA. Atrial fibrillation in heart failure: The sword of Damoclesrevisited. World J Cardiol 2013; 5(7): 215-27.</mixed-citation><mixed-citation xml:lang="en">Khan MA, Ahmed F, Neyses L, Mamas MA. Atrial fibrillation in heart failure: The sword of Damoclesrevisited. World J Cardiol 2013; 5(7): 215-27.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">National guidelines on the diagnosis and treatment of chronic heart failure (fourth revision). Serdechnaya Nedostatochnost' 2013; 14 (7): 1-25. In Russian (Национальные рекомендации по диагностике и лечению хронической сердечной недостаточности (четвертый пересмотр). Сердечная Недостаточность 2013; 14(7): 1-25).</mixed-citation><mixed-citation xml:lang="en">National guidelines on the diagnosis and treatment of chronic heart failure (fourth revision). Serdechnaya Nedostatochnost' 2013; 14 (7): 1-25. In Russian (Национальные рекомендации по диагностике и лечению хронической сердечной недостаточности (четвертый пересмотр). Сердечная Недостаточность 2013; 14(7): 1-25).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lip GYN, Laroche C, Popescu M, et al. Heart failure in patients with atrial fibrillation in Europe: a report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation. ur J Heart Fail 2015; 17: 570-82.</mixed-citation><mixed-citation xml:lang="en">Lip GYN, Laroche C, Popescu M, et al. Heart failure in patients with atrial fibrillation in Europe: a report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation. ur J Heart Fail 2015; 17: 570-82.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hart R., Pearce L., Aguilar M. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146:857—67.</mixed-citation><mixed-citation xml:lang="en">Hart R., Pearce L., Aguilar M. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146:857—67.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira J, Ezekowitz MD, Connolly SJ, et al; RE-LY Investigators. Dabigatran compared with warfarin in patients with atrial fibrillation and symptomatic heart failure: a subgroup analysis of the RE-LY trial. Eur J Heart Fail 2013;15(9):1053-61.</mixed-citation><mixed-citation xml:lang="en">Ferreira J, Ezekowitz MD, Connolly SJ, et al; RE-LY Investigators. Dabigatran compared with warfarin in patients with atrial fibrillation and symptomatic heart failure: a subgroup analysis of the RE-LY trial. Eur J Heart Fail 2013;15(9):1053-61.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Patel MR, Mahaffey KW, Garg J et al.; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365: 883-91.</mixed-citation><mixed-citation xml:lang="en">Patel MR, Mahaffey KW, Garg J et al.; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365: 883-91.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly SJ, Eikelboom J, Joyner C et al.; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364: 806-17.</mixed-citation><mixed-citation xml:lang="en">Connolly SJ, Eikelboom J, Joyner C et al.; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364: 806-17.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nieuwlaat R., Eurlings L.W., Cleland J.G. et al. Atrial fibrillation and heart failure in cardiology practice: reciprocal impact and combined management from the perspective of atrial fibrillation: results of the Euro Heart Survey on atrial fibrillation. J Am Coll Cardiol 2009;53:1690—8.</mixed-citation><mixed-citation xml:lang="en">Nieuwlaat R., Eurlings L.W., Cleland J.G. et al. Atrial fibrillation and heart failure in cardiology practice: reciprocal impact and combined management from the perspective of atrial fibrillation: results of the Euro Heart Survey on atrial fibrillation. J Am Coll Cardiol 2009;53:1690—8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kakkar A.K., Mueller I., Bassand J.P. et al.; GARFIELD Registry Investigators. Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD registry. PLoS One 2013;8:e63479.</mixed-citation><mixed-citation xml:lang="en">Kakkar A.K., Mueller I., Bassand J.P. et al.; GARFIELD Registry Investigators. Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD registry. PLoS One 2013;8:e63479.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lamberts M, Lip GY, Ruwald MH, et al. Antithrombotic treatment in patients with heart failure and associated atrial fibrillation and vascular disease: a nationwide cohort study. JACC 2014; 63(24):2689-98.</mixed-citation><mixed-citation xml:lang="en">Lamberts M, Lip GY, Ruwald MH, et al. Antithrombotic treatment in patients with heart failure and associated atrial fibrillation and vascular disease: a nationwide cohort study. JACC 2014; 63(24):2689-98.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Roy D, Talajic M, Nattel S, et al. Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med 2008;358:2667-2677.</mixed-citation><mixed-citation xml:lang="en">Roy D, Talajic M, Nattel S, et al. Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med 2008;358:2667-2677.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rienstra M., Damman K., Mulder B. Beta-Blockers and Outcome in Heart Failure and Atrial Fibrillation. A Meta-Analysis. JCHF 2013;1(1):21—8.</mixed-citation><mixed-citation xml:lang="en">Rienstra M., Damman K., Mulder B. Beta-Blockers and Outcome in Heart Failure and Atrial Fibrillation. A Meta-Analysis. JCHF 2013;1(1):21—8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kotecha D., Holmes J., Krum H., et al. Efficacy of β-blockers in patients with heart failure plus atrial fibrillation: an individualpatient data meta-analysis. Lancet 2014;S0140-6736(14): 61373—8.</mixed-citation><mixed-citation xml:lang="en">Kotecha D., Holmes J., Krum H., et al. Efficacy of β-blockers in patients with heart failure plus atrial fibrillation: an individualpatient data meta-analysis. Lancet 2014;S0140-6736(14): 61373—8.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Packer M., Fowler M., Roecker E. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 2002;106:2194—9.</mixed-citation><mixed-citation xml:lang="en">Packer M., Fowler M., Roecker E. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 2002;106:2194—9.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999;353:2001—7.</mixed-citation><mixed-citation xml:lang="en">MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999;353:2001—7.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">CIBIS-II Investigators and Committees. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial. Lancet 1999;353:9—13.</mixed-citation><mixed-citation xml:lang="en">CIBIS-II Investigators and Committees. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial. Lancet 1999;353:9—13.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Flather M., Shibata M., Coats A. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005;26:215—25.</mixed-citation><mixed-citation xml:lang="en">Flather M., Shibata M., Coats A. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005;26:215—25.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Li SJ, Sartipy U, Lund LH, et al. Prognostic Significance of Resting Heart Rate and Use of Beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry. Circ Heart Fail 2015;8(5):871-9.</mixed-citation><mixed-citation xml:lang="en">Li SJ, Sartipy U, Lund LH, et al. Prognostic Significance of Resting Heart Rate and Use of Beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry. Circ Heart Fail 2015;8(5):871-9.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen O., Bagger H., Kober L., Torp-Pedersen C., for the TRACE Study Group. Impact of congestive heart failure and left ventricular systolic function on the prognostic significance of atrial fibrillation and atrial flutter following acute myocardial infarction. Int J Cardiol 2005;100:65-71.</mixed-citation><mixed-citation xml:lang="en">Pedersen O., Bagger H., Kober L., Torp-Pedersen C., for the TRACE Study Group. Impact of congestive heart failure and left ventricular systolic function on the prognostic significance of atrial fibrillation and atrial flutter following acute myocardial infarction. Int J Cardiol 2005;100:65-71.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Parkash R, Tang AS, Sapp JL, et al. Approach to the catheter ablation technique of paroxysmal and persistent atrial fibrillation: a meta-analysis of the randomized controlled trials. J Cardiovasc Electrophysiol 2011;22:729-38.</mixed-citation><mixed-citation xml:lang="en">Parkash R, Tang AS, Sapp JL, et al. Approach to the catheter ablation technique of paroxysmal and persistent atrial fibrillation: a meta-analysis of the randomized controlled trials. J Cardiovasc Electrophysiol 2011;22:729-38.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Piccini JP, Lopes RD, Kong MH, et al. Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a metaanalysis of randomized, controlled trials. Circ Arrhythm Electrophysiol 2009;2:626-33.</mixed-citation><mixed-citation xml:lang="en">Piccini JP, Lopes RD, Kong MH, et al. Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a metaanalysis of randomized, controlled trials. Circ Arrhythm Electrophysiol 2009;2:626-33.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Jones DG, Haldar SK, Hussain W, et al. A randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure. J Am Coll Cardiol 2013;61(18):1894-903.</mixed-citation><mixed-citation xml:lang="en">Jones DG, Haldar SK, Hussain W, et al. A randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure. J Am Coll Cardiol 2013;61(18):1894-903.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Marrouche NF, Brachmann J; CASTLE-AF Steering Committee. Catheter ablation versus standard conventional treatment in patients with left ventricular dysfunction and atrial fibrillation (CASTLE-AF) study design. Pacing Clin Electrophysiol 2009;32(8):987-94.</mixed-citation><mixed-citation xml:lang="en">Marrouche NF, Brachmann J; CASTLE-AF Steering Committee. Catheter ablation versus standard conventional treatment in patients with left ventricular dysfunction and atrial fibrillation (CASTLE-AF) study design. Pacing Clin Electrophysiol 2009;32(8):987-94.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
