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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2015-11-6-626-633</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-443</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INNOVATIVE CARDIOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИННОВАЦИОННАЯ КАРДИОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Neoatherosclerosis in the stent</article-title><trans-title-group xml:lang="ru"><trans-title>НЕОАТЕРОСКЛЕРОЗ В СТЕНТЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Komkov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>м.н.с. лаборатории рентгенэндоваскулярных методов диагностики и лечения ГНИЦ ПМ</p></bio><email xlink:type="simple">artemkomkov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазаев</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazaev</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, руководитель той же лаборатории</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рязанова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryazanova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. той же лаборатории</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины 101990, Москва, Петроверигский пер., 10</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>11</volume><issue>6</issue><fpage>626</fpage><lpage>633</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Komkov A.A., Mazaev V.P., Ryazanova S.V., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Комков А.А., Мазаев В.П., Рязанова С.В.</copyright-holder><copyright-holder xml:lang="en">Komkov A.A., Mazaev V.P., Ryazanova S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/443">https://www.rpcardio.online/jour/article/view/443</self-uri><abstract><p>Achievements of interventional cardiology in the treatment of coronary artery disease are based on coronary balloon angioplasty with implanting bare metal stents and drug eluting stents. Questions of complications such as early stent thrombosis and restenosis of stent were solved in a considerable degree. However, with the lengthening of the followup period, the problem of late complications became obvious. Except endothelization and fibromuscular proliferation in stented coronary arteries the process of plaque formation has an important influence on later complications in follow-up period more than one year. This process was defined as neoatherosclerosis. This is verified by clinical manifestations of the disease, histological studies, angioscopy, intravascular ultrasound and optical-coherence tomography in stented patients. Dynamic observation of the condition in stentedcoronary arteries showed multistep proliferation with restenosis, its regression, and neoatherosclerosis development. Evidences of neoatherosclerosis formation in stented coronary arteries are considered in this review.</p></abstract><trans-abstract xml:lang="ru"><p>Достижения интервенционной кардиологии в лечении коронарной болезни сердца основаны на использовании баллонной ангиопластики коронарных артерий с применением голометаллических стентов и стентов с лекарственным покрытием. В значительной степени решены вопросы осложнений, таких как ранний тромбоз и рестеноз стента. Однако, по мере удлинения сроков наблюдения, стала очевидной проблема поздних осложнений. Было установлено, что кроме процессов реэндотелизации и фибромышечной пролиферации, развивающихся в коронарных артериях после стентирования при сроках наблюдения продолжительностью более одного года, важную роль в развитии поздних осложнений играет процесс формирования атеросклеротической бляшки, обозначенный как неоатеросклероз. Это подтверждается клиническими проявлениями болезни у пациентов, подвергшихся коронарному стентированию, результатами гистологических исследований, ангиоскопической картиной, данными внутрисосудистого ультразвука и оптической когерентной томографии. Динамическое наблюдение за состоянием в стентированных артериях показали многоэтапность пролиферативных процессов с формированием рестеноза, его регрессией и развитием неоатеросклероза. В данном обзоре рассматриваются доказательства развития неоатеросклероза в стентированных коронарных артериях.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>неоатеросклероз</kwd><kwd>late catch-up</kwd><kwd>отдаленный тромбоз стента</kwd><kwd>осложнения рестеноза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neoatherosclerosis</kwd><kwd>late catch-up</kwd><kwd>late stent thrombosis</kwd><kwd>restenosis complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Serruys PW, de Jaegere P, Kiemeneij F, et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease: Benestent Study Group. N EnglJ Med 1994;331:489-95.</mixed-citation><mixed-citation xml:lang="en">Serruys PW, de Jaegere P, Kiemeneij F, et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease: Benestent Study Group. N EnglJ Med 1994;331:489-95.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Komkov AA, Mazaev VP, Rjazanova SV. Study protocol “Neoatheroclerosis analysis” for investigating clinical flowing and neoatherosclerosis outcomes in prolonged follow-up after PCI. Abstract Book of National Russian Cardiology Congress. Moscow, 2015 September 22-25. Moscow: RCS; 2015:340. In Russian (Комков А. А., Мазаев В. П., Рязанова С. В. Протокол исследования «Анализ неоатеросклероза» по изучению клинического течения и исходов неоатеросклероза на отдаленных сроках после высокотехнологичных чрескожных коронарных вмешательств. Тезисы Российского национального конгресса кардиологов. Москва, 22-25 сентября 2015. М.: РКО; 2015: 340)</mixed-citation><mixed-citation xml:lang="en">Komkov AA, Mazaev VP, Rjazanova SV. Study protocol “Neoatheroclerosis analysis” for investigating clinical flowing and neoatherosclerosis outcomes in prolonged follow-up after PCI. Abstract Book of National Russian Cardiology Congress. Moscow, 2015 September 22-25. Moscow: RCS; 2015:340. In Russian (Комков А. А., Мазаев В. П., Рязанова С. В. Протокол исследования «Анализ неоатеросклероза» по изучению клинического течения и исходов неоатеросклероза на отдаленных сроках после высокотехнологичных чрескожных коронарных вмешательств. Тезисы Российского национального конгресса кардиологов. Москва, 22-25 сентября 2015. М.: РКО; 2015: 340)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura T, Yokoi H, Nakagawa Y, et al. Three-year follow-up after implantation of metallic coronary-artery stents. N Engl J Med 1996; 334:561- 6.</mixed-citation><mixed-citation xml:lang="en">Kimura T, Yokoi H, Nakagawa Y, et al. Three-year follow-up after implantation of metallic coronary-artery stents. N Engl J Med 1996; 334:561- 6.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Nobuyoshi M, Kimura T, Ohishi H, et al. Restenosis after percuta- neous transluminal coronary angioplasty: pathologic observation in 20 patients. J Am Coll Cardiol 1991;17:433-9.</mixed-citation><mixed-citation xml:lang="en">Nobuyoshi M, Kimura T, Ohishi H, et al. Restenosis after percuta- neous transluminal coronary angioplasty: pathologic observation in 20 patients. J Am Coll Cardiol 1991;17:433-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura T, Abe K, Shizuta S, et al. Long-term clinical and angiographic follow-up after coronary stent placement in native coronary arteries. Circulation 2002;105:2986-91.</mixed-citation><mixed-citation xml:lang="en">Kimura T, Abe K, Shizuta S, et al. Long-term clinical and angiographic follow-up after coronary stent placement in native coronary arteries. Circulation 2002;105:2986-91.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Liistro F, Stankovic G, Di Mario C. First clinical experience with a paclitaxel derivate-eluting polymer stent system implantation for in-stent restenosis: immediate and long-term clinical and angiographic outcome. Circulation 2002;105:1883-6.</mixed-citation><mixed-citation xml:lang="en">Liistro F, Stankovic G, Di Mario C. First clinical experience with a paclitaxel derivate-eluting polymer stent system implantation for in-stent restenosis: immediate and long-term clinical and angiographic outcome. Circulation 2002;105:1883-6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Finn AV, Nakazawa G, Joner M. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol 2007;27:1500-10.</mixed-citation><mixed-citation xml:lang="en">Finn AV, Nakazawa G, Joner M. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol 2007;27:1500-10.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chen MS, John JM, Chew DP, et al. Bare metal stent restenosis is not a benign clinical entity. Am Heart J 2006;151:1260-4.</mixed-citation><mixed-citation xml:lang="en">Chen MS, John JM, Chew DP, et al. Bare metal stent restenosis is not a benign clinical entity. Am Heart J 2006;151:1260-4.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Grube E, Dawkins K, Guagliumi G, et al. TAXUS VI final 5-year results: a multicentre, randomised trial comparing polymer-based moderate-release paclitaxel-eluting stent with a bare metal stent for treatment of long, complex coronary artery lesions. EuroIntervention 2009;4:572-7.</mixed-citation><mixed-citation xml:lang="en">Grube E, Dawkins K, Guagliumi G, et al. TAXUS VI final 5-year results: a multicentre, randomised trial comparing polymer-based moderate-release paclitaxel-eluting stent with a bare metal stent for treatment of long, complex coronary artery lesions. EuroIntervention 2009;4:572-7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nakazawa G, Finn AV, Vorpahl M, et al. Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents. J Am Coll Cardiol 2011;57:390-8.</mixed-citation><mixed-citation xml:lang="en">Nakazawa G, Finn AV, Vorpahl M, et al. Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents. J Am Coll Cardiol 2011;57:390-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Park DW, Hong MK, Mintz GS, et al. Two-year follow-up of the quantitative angiographic and volumetric intravascular ultrasound analysis after nonpolymeric paclitaxel-eluting stent implantation: late "catch-up" phenomenon from ASPECT study. J Am Coll Cardiol 2006;48:2432-9.</mixed-citation><mixed-citation xml:lang="en">Park DW, Hong MK, Mintz GS, et al. Two-year follow-up of the quantitative angiographic and volumetric intravascular ultrasound analysis after nonpolymeric paclitaxel-eluting stent implantation: late "catch-up" phenomenon from ASPECT study. J Am Coll Cardiol 2006;48:2432-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nakagawa Y, Kimura T, Morimoto T, et al. Incidence and risk factors of late target lesion revascularization after sirolimus-eluting stent implantation (3-year follow-up of the j-Cypher Registry). Am J Cardiol 2010;106:329-36.</mixed-citation><mixed-citation xml:lang="en">Nakagawa Y, Kimura T, Morimoto T, et al. Incidence and risk factors of late target lesion revascularization after sirolimus-eluting stent implantation (3-year follow-up of the j-Cypher Registry). Am J Cardiol 2010;106:329-36.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kang SJ, Park DW, Mintz GS, et al. Serial long-term vascular changes after drug-eluting stent implantation assessed by serial volumetric intravascular ultrasound analysis. Am J Cardiol 2010;105:1402-8.</mixed-citation><mixed-citation xml:lang="en">Kang SJ, Park DW, Mintz GS, et al. Serial long-term vascular changes after drug-eluting stent implantation assessed by serial volumetric intravascular ultrasound analysis. Am J Cardiol 2010;105:1402-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Virmani R, Liistro F, Stankovic G, et al. Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans. Circulation 2002;106:2649-51.</mixed-citation><mixed-citation xml:lang="en">Virmani R, Liistro F, Stankovic G, et al. Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans. Circulation 2002;106:2649-51.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193-202.</mixed-citation><mixed-citation xml:lang="en">Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193-202.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Carter AJ, Aggarwal M, Kopia GA, et al. Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res 2004;63:617-24.</mixed-citation><mixed-citation xml:lang="en">Carter AJ, Aggarwal M, Kopia GA, et al. Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res 2004;63:617-24.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Farb A, Heller PF, Shroff S, et al. Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation 2001;104:473-9.</mixed-citation><mixed-citation xml:lang="en">Farb A, Heller PF, Shroff S, et al. Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation 2001;104:473-9.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chieffo A, Foglieni C, Nodari RL, et al. Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents. Am J Cardiol 2009;104:1660-7.</mixed-citation><mixed-citation xml:lang="en">Chieffo A, Foglieni C, Nodari RL, et al. Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents. Am J Cardiol 2009;104:1660-7.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Arbustini E, De Servi S, Bramucci E, et al. Comparison of coronary lesions obtained by directional coronary atherectomy in unstable angina, stable angina, and restenosis after either atherectomy or angioplasty. Am J Cardiol 1995;75:675-82.</mixed-citation><mixed-citation xml:lang="en">Arbustini E, De Servi S, Bramucci E, et al. Comparison of coronary lesions obtained by directional coronary atherectomy in unstable angina, stable angina, and restenosis after either atherectomy or angioplasty. Am J Cardiol 1995;75:675-82.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue K, Abe K, Ando K, et al. Pathological analyses of long-term intracoronary Palmaz-Schatz stenting: Is its efficacy permanent? Car- diovasc Pathol 2004;13:109-15.</mixed-citation><mixed-citation xml:lang="en">Inoue K, Abe K, Ando K, et al. Pathological analyses of long-term intracoronary Palmaz-Schatz stenting: Is its efficacy permanent? Car- diovasc Pathol 2004;13:109-15.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hasegawa K, Tamai H, Kyo E, et al. Histopathological findings of new in-stent lesions developed beyond five years. Catheter Cardiovasc Interv 2006;68:554-8.</mixed-citation><mixed-citation xml:lang="en">Hasegawa K, Tamai H, Kyo E, et al. Histopathological findings of new in-stent lesions developed beyond five years. Catheter Cardiovasc Interv 2006;68:554-8.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Nakazawa G, Vorpahl M, Finn AV, et al. One step forward and two steps back with drug-eluting stents. J Am Coll Cardiol Img 2009;2:623-8.</mixed-citation><mixed-citation xml:lang="en">Nakazawa G, Vorpahl M, Finn AV, et al. One step forward and two steps back with drug-eluting stents. J Am Coll Cardiol Img 2009;2:623-8.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Nakazawa G, Otsuka F, Nakano M, et al. The pathology of neoath- erosclerosis in human coronary implants bare-metal and drug-eluting stents. J Am Coll Cardiol 2011;57:1314-22.</mixed-citation><mixed-citation xml:lang="en">Nakazawa G, Otsuka F, Nakano M, et al. The pathology of neoath- erosclerosis in human coronary implants bare-metal and drug-eluting stents. J Am Coll Cardiol 2011;57:1314-22.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Park SJ, Kang SJ, Virmani R, et al. In-stent neoatherosclerosis: a final common pathway of late stent failure. J Am Coll Cardiol 2012;59:2051-7</mixed-citation><mixed-citation xml:lang="en">Park SJ, Kang SJ, Virmani R, et al. In-stent neoatherosclerosis: a final common pathway of late stent failure. J Am Coll Cardiol 2012;59:2051-7</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yokoyama S, Takano M, Yamamoto M, et al. Extended follow-up by serial angioscopic observation for bare-metal stents in native coronary arteries: from healing response to atherosclerotic transformation of neointima. Circ Cardiovasc Interv 2009;2:205-12.</mixed-citation><mixed-citation xml:lang="en">Yokoyama S, Takano M, Yamamoto M, et al. Extended follow-up by serial angioscopic observation for bare-metal stents in native coronary arteries: from healing response to atherosclerotic transformation of neointima. Circ Cardiovasc Interv 2009;2:205-12.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ueda Y, Nanto S, Komamura K, Kodama K. Neointimal coverage of stents in human coronary arteries observed by angioscopy. J Am Coll Cardiol 1994;23:341-6.</mixed-citation><mixed-citation xml:lang="en">Ueda Y, Nanto S, Komamura K, Kodama K. Neointimal coverage of stents in human coronary arteries observed by angioscopy. J Am Coll Cardiol 1994;23:341-6.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Burke AP, Kolodgie FD, Farb A, et al. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 2001;103:934 - 40.</mixed-citation><mixed-citation xml:lang="en">Burke AP, Kolodgie FD, Farb A, et al. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 2001;103:934 - 40.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002;106:2200-6.</mixed-citation><mixed-citation xml:lang="en">Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002;106:2200-6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Appleby CE, Bui S, Dzav ́ık V. A calcified neointima-“stent” within a stent. J Invasive Cardiol 2009;21:141-3.</mixed-citation><mixed-citation xml:lang="en">Appleby CE, Bui S, Dzav ́ık V. A calcified neointima-“stent” within a stent. J Invasive Cardiol 2009;21:141-3.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Fineschi M, Carrera A, Gori T. Atheromatous degeneration of the neointima in a bare metal stent: intravascular ultrasound evidence. J Cardiovasc Med 2009;10:572-3.</mixed-citation><mixed-citation xml:lang="en">Fineschi M, Carrera A, Gori T. Atheromatous degeneration of the neointima in a bare metal stent: intravascular ultrasound evidence. J Cardiovasc Med 2009;10:572-3.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hoole SP, Starovoytov A, Hamburger JN. In-stent restenotic lesions can rupture: a case against plaque sealing. Catheter Cardiovasc Interv 2010;77:841-2.</mixed-citation><mixed-citation xml:lang="en">Hoole SP, Starovoytov A, Hamburger JN. In-stent restenotic lesions can rupture: a case against plaque sealing. Catheter Cardiovasc Interv 2010;77:841-2.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kang SJ, Mintz GS, Park DW, et al. Tissue characterization of in-stent neointima using intravascular ultrasound radiofrequency data analysis. Am J Cardiol 2010;106:1561-5.</mixed-citation><mixed-citation xml:lang="en">Kang SJ, Mintz GS, Park DW, et al. Tissue characterization of in-stent neointima using intravascular ultrasound radiofrequency data analysis. Am J Cardiol 2010;106:1561-5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Habara M, Terashima M, Suzuki T. Detection of atherosclerotic progression with rupture of degenerated in-stent intima five years after bare-metal stent implantation using optical coherence tomography. J Invasive Cardiol 2009;21:552-3.</mixed-citation><mixed-citation xml:lang="en">Habara M, Terashima M, Suzuki T. Detection of atherosclerotic progression with rupture of degenerated in-stent intima five years after bare-metal stent implantation using optical coherence tomography. J Invasive Cardiol 2009;21:552-3.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gonzalo N, Serruys PW, Okamura T, et al. Optical coherence tomography patterns of stent restenosis. Am Heart J 2009;158:284-93.</mixed-citation><mixed-citation xml:lang="en">Gonzalo N, Serruys PW, Okamura T, et al. Optical coherence tomography patterns of stent restenosis. Am Heart J 2009;158:284-93.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Takano M, Yamamoto M, Inami S, et al. Appearance of lipid-laden intima and neovascularization after implantation of bare-metal stents extended late-phase observation by intracoronary optical coherence tomography. J Am Coll Cardiol 2009;55:26-32.</mixed-citation><mixed-citation xml:lang="en">Takano M, Yamamoto M, Inami S, et al. Appearance of lipid-laden intima and neovascularization after implantation of bare-metal stents extended late-phase observation by intracoronary optical coherence tomography. J Am Coll Cardiol 2009;55:26-32.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kang SJ, Mintz GS, Akasaka T, et al. Optical coherent tomographic analysis of in-stent neo-atherosclerosis after drug-eluting stent im- plantation. Circulation 2011;123:2913-5.</mixed-citation><mixed-citation xml:lang="en">Kang SJ, Mintz GS, Akasaka T, et al. Optical coherent tomographic analysis of in-stent neo-atherosclerosis after drug-eluting stent im- plantation. Circulation 2011;123:2913-5.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Taniwaki M, Windecker S, Zaugg S, et al. The association between in-stent neoatherosclerosis and native coronary artery disease progression: a long-term angiographic and optical coherence tomography cohort study. Eur Heart J 2015;36:2167-2176</mixed-citation><mixed-citation xml:lang="en">Taniwaki M, Windecker S, Zaugg S, et al. The association between in-stent neoatherosclerosis and native coronary artery disease progression: a long-term angiographic and optical coherence tomography cohort study. Eur Heart J 2015;36:2167-2176</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Iijima R, Araki T, Nagashima Y, et al. Incidence and predictors of the late catch-up phenomenon after drug-eluting stent implantation. Intern J of Cardiol 2013;168:2588-2592</mixed-citation><mixed-citation xml:lang="en">Iijima R, Araki T, Nagashima Y, et al. Incidence and predictors of the late catch-up phenomenon after drug-eluting stent implantation. Intern J of Cardiol 2013;168:2588-2592</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Granata F, Attizani G, Tartaglione В et al. Atypical "vacuum" inside of neoatherosclerosis long term after DES implantation: Insights from optical coherence tomography. Intern J of Cardiol 2015;199:221-222</mixed-citation><mixed-citation xml:lang="en">Granata F, Attizani G, Tartaglione В et al. Atypical "vacuum" inside of neoatherosclerosis long term after DES implantation: Insights from optical coherence tomography. Intern J of Cardiol 2015;199:221-222</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Yonetsu T, Kato K, Kim SJ, et al. Predictors for Neoatherosclerosis: A Retrospective Observational Study from the Optical Coherence Tomography Registry. Circ Cardiovasc Imaging 2012;5:748-755</mixed-citation><mixed-citation xml:lang="en">Yonetsu T, Kato K, Kim SJ, et al. Predictors for Neoatherosclerosis: A Retrospective Observational Study from the Optical Coherence Tomography Registry. Circ Cardiovasc Imaging 2012;5:748-755</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Yonetsu T, Kim JS, Kato K, et al. Comparison of Incidence and Time Course of Neoatherosclerosis Between Bare Metal Stents and Drug-Eluting Stents Using Optical Coherence Tomography. Am J Cardiol 2012;110:933-939</mixed-citation><mixed-citation xml:lang="en">Yonetsu T, Kim JS, Kato K, et al. Comparison of Incidence and Time Course of Neoatherosclerosis Between Bare Metal Stents and Drug-Eluting Stents Using Optical Coherence Tomography. Am J Cardiol 2012;110:933-939</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida K, Sadamatsu K. A severely calcified neointima 9 years after bare metal stent implantation. Cardiovasc Revasc Med 2012;13:350-352</mixed-citation><mixed-citation xml:lang="en">Yoshida K, Sadamatsu K. A severely calcified neointima 9 years after bare metal stent implantation. Cardiovasc Revasc Med 2012;13:350-352</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193-202.</mixed-citation><mixed-citation xml:lang="en">Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193-202.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Nakazawa G, Yazdani SK, Finn AV, et al. Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol 2010;55:1679-87.</mixed-citation><mixed-citation xml:lang="en">Nakazawa G, Yazdani SK, Finn AV, et al. Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol 2010;55:1679-87.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Nakazawa G, Finn AV, Joner M, et al. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. Circulation 2008;118:1138-45.</mixed-citation><mixed-citation xml:lang="en">Nakazawa G, Finn AV, Joner M, et al. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. Circulation 2008;118:1138-45.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Higo T, Ueda Y, Oyabu J, et al. Atherosclerotic and thrombogenic neointima formed over sirolimus drugeluting stent: an angioscopic study. J Am Coll Cardiol Img 2009;2:616-24.</mixed-citation><mixed-citation xml:lang="en">Higo T, Ueda Y, Oyabu J, et al. Atherosclerotic and thrombogenic neointima formed over sirolimus drugeluting stent: an angioscopic study. J Am Coll Cardiol Img 2009;2:616-24.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Lee CW, Kang SJ, Park DW, et al. Intravascular ultrasound findings in patients with very late stent thrombosis after either drug-eluting or bare-metal stent implantation. J Am Coll Cardiol 2010;55:1936-42.</mixed-citation><mixed-citation xml:lang="en">Lee CW, Kang SJ, Park DW, et al. Intravascular ultrasound findings in patients with very late stent thrombosis after either drug-eluting or bare-metal stent implantation. J Am Coll Cardiol 2010;55:1936-42.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yamaji K, Kubo S, Inoue K, et al. Association of Localized Hypersensitivity and In-Stent Neoatherosclerosis with the Very Late Drug-Eluting Stent Thrombosis. PLoS ONE 2014;9(11):e113870</mixed-citation><mixed-citation xml:lang="en">Yamaji K, Kubo S, Inoue K, et al. Association of Localized Hypersensitivity and In-Stent Neoatherosclerosis with the Very Late Drug-Eluting Stent Thrombosis. PLoS ONE 2014;9(11):e113870</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Tereshhenko A. S., Mironov V. M., Merkulov E. V., et al. Late and very late drug-elution stent thrombosis. Ateroskleroz i Dislipidemii 2014;1:9-16. Russian (Терещенко А. С., Миронов В. М., Меркулов Е. В., и др. Поздние и очень поздние тромбозы стентов с лекарственным покрытием. Атеросклероз и Дислипидемии 2014;1:9-16)</mixed-citation><mixed-citation xml:lang="en">Tereshhenko A. S., Mironov V. M., Merkulov E. V., et al. Late and very late drug-elution stent thrombosis. Ateroskleroz i Dislipidemii 2014;1:9-16. Russian (Терещенко А. С., Миронов В. М., Меркулов Е. В., и др. Поздние и очень поздние тромбозы стентов с лекарственным покрытием. Атеросклероз и Дислипидемии 2014;1:9-16)</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Karpov JuA, Samko AN, Buza VV. Coronary Angioplasty and stenting. Moscow: MIA; 2010. In Russian (Карпов Ю.А., Самко А.Н., Буза В.В. Коронарная ангиопластика и стентирование. Москва: МИА; 2010)</mixed-citation><mixed-citation xml:lang="en">Karpov JuA, Samko AN, Buza VV. Coronary Angioplasty and stenting. Moscow: MIA; 2010. In Russian (Карпов Ю.А., Самко А.Н., Буза В.В. Коронарная ангиопластика и стентирование. Москва: МИА; 2010)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
