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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2015-11-6-650-654</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-447</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>Cardiometabolic properties of telmisartan: new perspectives for use</article-title><trans-title-group xml:lang="ru"><trans-title>КАРДИОМЕТАБОЛИЧЕСКИЕ СВОЙСТВА ТЕЛМИСАРТАНА: НОВЫЕ ПЕРСПЕКТИВЫ ДЛЯ ИСПОЛЬЗОВАНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, первый заместитель директора по научной и лечебной работе ГНИЦ ПМ</p></bio><email xlink:type="simple">drapkina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомичева</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomicheva</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор ГНИЦ ПМ</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины 101990, Москва, Петроверигский пер., 10</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>11</volume><issue>6</issue><fpage>650</fpage><lpage>654</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Drapkina O.M., Fomicheva E.I., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Драпкина О.М., Фомичева Е.И.</copyright-holder><copyright-holder xml:lang="en">Drapkina O.M., Fomicheva E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/447">https://www.rpcardio.online/jour/article/view/447</self-uri><abstract><p>Modern clinical studies periodically open new prospects for the use of well-known products, lighting other facets of the point of application of these drugs. Application of the last representatives of sartans, not only as a drug with proven antihypertensive effect, but also in terms of their effects on metabolic processes, can be considered as such an example.</p></abstract><trans-abstract xml:lang="ru"><p>Современные клинические наблюдения периодически открывают новые перспективы для использования давно известных препаратов, освещая другие грани и точки приложения этих лекарств. В качестве такого примера можно рассмотреть использование последних представителей сартанов, не только как препаратов с доказанным антигипертензивным эффектом, но и с точки зрения воздействия на метаболические процессы.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>антагонисты рецепторов ангиотензина II</kwd><kwd>телмисартан</kwd><kwd>кардиометаболические эффекты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>angiotensin II receptor blockers</kwd><kwd>telmisartan</kwd><kwd>cardiometabolic effects</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Boytsov SA, Jakushin SS Martsevich SY, et al. Register outpatient cardiovascular disease REKVAZA. Ration Pharmacother Cardiol 2013; 9 (1): 4-14. In Russian (Бойцов С.А., Якушин С.С., Марцевич С.Ю., и др. Амбулаторно-поликлинический регистр кардиоваскулярных заболеваний РЕКВАЗА. Рациональная Фармакотерапия в Кардиологии 2013; 9 (1): 4-14).</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Jakushin SS Martsevich SY, et al. Register outpatient cardiovascular disease REKVAZA. Ration Pharmacother Cardiol 2013; 9 (1): 4-14. In Russian (Бойцов С.А., Якушин С.С., Марцевич С.Ю., и др. Амбулаторно-поликлинический регистр кардиоваскулярных заболеваний РЕКВАЗА. Рациональная Фармакотерапия в Кардиологии 2013; 9 (1): 4-14).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Diagnosis and treatment of hypertension. Russian guidelines (fourth revision). Sistemnye Gipertenzii 2010; 3: 3-25. In Russian (Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр). Системные Гипертензии 2010; 3: 3-25).</mixed-citation><mixed-citation xml:lang="en">Diagnosis and treatment of hypertension. Russian guidelines (fourth revision). Sistemnye Gipertenzii 2010; 3: 3-25. In Russian (Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр). Системные Гипертензии 2010; 3: 3-25).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34: 2159-219.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34: 2159-219.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Schmieder R, Delles C, Mimran A, et al. Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care. 2007;30:1351-1356.</mixed-citation><mixed-citation xml:lang="en">Schmieder R, Delles C, Mimran A, et al. Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care. 2007;30:1351-1356.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bakris G., Burgess E., Weir M. et al.; on behalf of the AMADEO Study Investigators. Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy. Kidney Int 2008; 74 (3): 364.</mixed-citation><mixed-citation xml:lang="en">Bakris G., Burgess E., Weir M. et al.; on behalf of the AMADEO Study Investigators. Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy. Kidney Int 2008; 74 (3): 364.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Galle J, Schwedhelm E, Pinnetti S et al. VIVALDI investigators. Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy. Nephrol Dial Transplant 2008; 23 (10): 3174-83.</mixed-citation><mixed-citation xml:lang="en">Galle J, Schwedhelm E, Pinnetti S et al. VIVALDI investigators. Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy. Nephrol Dial Transplant 2008; 23 (10): 3174-83.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">MakinoH, Haneda M, Babazono T, et al. The telmisartan renoprotective study from incipient nephropathy to overt nephropathy - rationale, study design, treatment plan and baseline characteristics of the incipientto overt: angiotensin iireceptor blocker,telmisartan, investigation on type 2 diabetic nephropathy (INNOVATION) Study. J Int Med Res 2005; 33: 677-86.</mixed-citation><mixed-citation xml:lang="en">MakinoH, Haneda M, Babazono T, et al. The telmisartan renoprotective study from incipient nephropathy to overt nephropathy - rationale, study design, treatment plan and baseline characteristics of the incipientto overt: angiotensin iireceptor blocker,telmisartan, investigation on type 2 diabetic nephropathy (INNOVATION) Study. J Int Med Res 2005; 33: 677-86.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">The ONTARGET investigators. Telmisartan, ramipril or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-59.</mixed-citation><mixed-citation xml:lang="en">The ONTARGET investigators. Telmisartan, ramipril or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-59.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Miura S, Karnia SS, Saku K. Review: angiotensin II type I receptor blockers: class effects versus molecular effects. J Renin Angiotensin Aldosterone Syst 2011; 12 (1): 1-7.</mixed-citation><mixed-citation xml:lang="en">Miura S, Karnia SS, Saku K. Review: angiotensin II type I receptor blockers: class effects versus molecular effects. J Renin Angiotensin Aldosterone Syst 2011; 12 (1): 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mori H, Okada Y, Arao T, et al. Telmisartan at 80 mg/day increases higt-molecular-weight adiponectin levels and improves insulinresistance in diabetic patients. Adv Ther 2012; 29 (7): 635-44.</mixed-citation><mixed-citation xml:lang="en">Mori H, Okada Y, Arao T, et al. Telmisartan at 80 mg/day increases higt-molecular-weight adiponectin levels and improves insulinresistance in diabetic patients. Adv Ther 2012; 29 (7): 635-44.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004;43(5):993-1002.</mixed-citation><mixed-citation xml:lang="en">Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004;43(5):993-1002.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schupp M, Clemenz M, Gineste R et al. Molecular characterization of new selective peroxisome proliferator-activated receptor c modulators with angiotensin receptor blocker activity. Diabetes, 2005; 54: 3442-52.</mixed-citation><mixed-citation xml:lang="en">Schupp M, Clemenz M, Gineste R et al. Molecular characterization of new selective peroxisome proliferator-activated receptor c modulators with angiotensin receptor blocker activity. Diabetes, 2005; 54: 3442-52.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hara K, Horikoshi M, Yamauchi T et al. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care, 2006; 29: 1357-62.</mixed-citation><mixed-citation xml:lang="en">Hara K, Horikoshi M, Yamauchi T et al. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care, 2006; 29: 1357-62.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lara-Castro C, Luo N, Wallace P, et al. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes, 2006; 55: 249-59.</mixed-citation><mixed-citation xml:lang="en">Lara-Castro C, Luo N, Wallace P, et al. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes, 2006; 55: 249-59.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Suksomboon N, Poolsup N, Prasit T. Systematic review of the effect of telmisartan on insulin sensitivity in hypertensive patients with insulin resistance or diabetes. J of Clinical Pharmacy and Therapeutics 2012; 37:3; 319-27.</mixed-citation><mixed-citation xml:lang="en">Suksomboon N, Poolsup N, Prasit T. Systematic review of the effect of telmisartan on insulin sensitivity in hypertensive patients with insulin resistance or diabetes. J of Clinical Pharmacy and Therapeutics 2012; 37:3; 319-27.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kurtz T W. Treating the metabolic syndrome: telmisartan as a peroxisome proliferatoractivated receptorgamma activator. Acta Diabetologica, 2005; 2005:42.</mixed-citation><mixed-citation xml:lang="en">Kurtz T W. Treating the metabolic syndrome: telmisartan as a peroxisome proliferatoractivated receptorgamma activator. Acta Diabetologica, 2005; 2005:42.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Francischetti E A, Celoria B M, Francischetti A, Genelhu V A. Treatment of hypertension in individuals with the cardiometabolic syndrome: role of an angiotensin II receptor blocker, telmisartan. Expert Review of Cardiovascular Therapy 2008; 6: 280-303.</mixed-citation><mixed-citation xml:lang="en">Francischetti E A, Celoria B M, Francischetti A, Genelhu V A. Treatment of hypertension in individuals with the cardiometabolic syndrome: role of an angiotensin II receptor blocker, telmisartan. Expert Review of Cardiovascular Therapy 2008; 6: 280-303.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Takagi H, Niwa M, Mizuno Y, Umemoto T. Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome. J of the American Society of Hypertension 2013; 7:3; 229-35.</mixed-citation><mixed-citation xml:lang="en">Takagi H, Niwa M, Mizuno Y, Umemoto T. Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome. J of the American Society of Hypertension 2013; 7:3; 229-35.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Derosa G, Cicero AF, D’Angelo A, Ragonesi PD, Ciccarelli L, Piccinni MN, et al. Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: Effects on insulin-resistance, leptin and tumor necrosis factor-alpha. Hypertens Res 2006; 29: 849-56.</mixed-citation><mixed-citation xml:lang="en">Derosa G, Cicero AF, D’Angelo A, Ragonesi PD, Ciccarelli L, Piccinni MN, et al. Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: Effects on insulin-resistance, leptin and tumor necrosis factor-alpha. Hypertens Res 2006; 29: 849-56.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ichikawa Y. Comparative effects of telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome. Intern Med 2007; 46: 1331-6.</mixed-citation><mixed-citation xml:lang="en">Ichikawa Y. Comparative effects of telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome. Intern Med 2007; 46: 1331-6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kishi T, Hirooka Y, Konno S, Sunagawa K. Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome. J Hypertens 2012; 30:1646-55.</mixed-citation><mixed-citation xml:lang="en">Kishi T, Hirooka Y, Konno S, Sunagawa K. Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome. J Hypertens 2012; 30:1646-55.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Blüher M, Brennan AM, Kelesidis T, et al. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care 2007; 30:280-5.</mixed-citation><mixed-citation xml:lang="en">Blüher M, Brennan AM, Kelesidis T, et al. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care 2007; 30:280-5.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mori H, Okada Y, Arao T, Nishida K, Tanaka Y. Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients. Original research. Advances in Therapy 2012; 29:7 635-44.</mixed-citation><mixed-citation xml:lang="en">Mori H, Okada Y, Arao T, Nishida K, Tanaka Y. Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients. Original research. Advances in Therapy 2012; 29:7 635-44.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mudaliar S, Chang AR, Henry RR. Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications. Endocr Pract 2003; 9:406-16.</mixed-citation><mixed-citation xml:lang="en">Mudaliar S, Chang AR, Henry RR. Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications. Endocr Pract 2003; 9:406-16.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
