rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2007-3-3-52-59rpcardio-458Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИRESISTANCE TO ANTIPLATELET DRUGS IN PATIENTS WITH ISCHEMIC HEART DISEASEРЕЗИСТЕНТНОСТЬ К АНТИТРОМБОЦИТАРНЫМ ПРЕПАРАТАМ У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦААйнетдиноваД. Х.AynetdinovaD. H.

Кафедра факультетской терапии №1 

Chair of Faculty therapy №1

УдовиченкоА. Е.UdovichenkoA. E.

Кафедра факультетской терапии №1 

Chair of Faculty therapy №1

СулимовВ. А.SulimovV. A.

Кафедра факультетской терапии №1 

Chair of Faculty therapy №1

Московская медицинская академия им. И. М. СеченоваРоссияMoscow Medical Academy named after I.M. SechenovRussian Federation200702012016335259Copyright © Aynetdinova D.H., Udovichenko A.E., Sulimov V.A., 20152015Айнетдинова Д.Х., Удовиченко А.Е., Сулимов В.А.Aynetdinova D.H., Udovichenko A.E., Sulimov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/458

The clinical, cell and genetic factors are distinguished among reasons for resistance to antiplatelet drugs. There are many methods to detect sensitivity to antiplatelet drugs, but they all have disadvantages. Moreover, there is no unified approach for interpretation of received results, and no recommendations for their practical use. It is necessary to work out unified procedure to assess platelet function, to define indications for its usage and to work out unified criteria of resistance. Individualized approach and each patient’s peculiarities consideration are essential when prescribing antiplatelet therapy.

Среди причин резистентности к антитромбоцитарным препаратам выделяют клинические, клеточные и генетические факторы. Существует множество методов определения чувствительности к антитромбоцитарным препаратам, но ни один из них не лишен недостатков. Кроме того, нет единого подхода по интерпретации полученных результатов и не разработано рекомендаций по их использованию в практической деятельности. Целесообразна разработка унифицированной методики для оценки функции тромбоцитов, определение показаний для ее использования, разработка единых критериев резистентности. При назначении антиагрегантной терапии важен индивидуализированный подход, учет особенностей каждого пациента.

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The authors declare that there are no conflicts of interest present.