rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2007-3-5-40-43rpcardio-545Research ArticleORIGINAL STUDIESОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯEFFECT OF SPIRAPRIL ON THE LENGTH OF INTERICTAL INTERVAL IN PAROXYSMAL ATRIAL FIBRILLATIONВЛИЯНИЕ СПИРАПРИЛА НА ДЛИТЕЛЬНОСТЬ МЕЖПРИСТУПНОГО ИНТЕРВАЛА ПРИ ПАРОКСИЗМАЛЬНОЙ МЕРЦАТЕЛЬНОЙ АРИТМИИЧихиреваЛ. Н.ChikhirevaL. N.МалаховВ. И.MalahovV. I.БыковаЕ. С.BykovaE. S.СоколовС. Ф.SokolovS. F.Российский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А.Л. Мясникова, МоскваРоссияRussian Cardiological Research Complex of Rosmedtechnology, Institute of Clinical Cardiology named after A.L. Myasnikov, MoscowRussian Federation200703012016354553Copyright © Chikhireva L.N., Malahov V.I., Bykova E.S., Sokolov S.F., 20152015Чихирева Л.Н., Малахов В.И., Быкова Е.С., Соколов С.Ф.Chikhireva L.N., Malahov V.I., Bykova E.S., Sokolov S.F.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/545Aim

Aim. To evaluate effects of angiotensin converting enzyme inhibitor spirapril on efficacy of preventive antiarrhythmic therapy in patients with paroxysmal atrial fibrillation (AF).

Material and methods

Material and methods. 40 patients with paroxysmal AF were involved in open-label, cross-over study with periods of antiarrhythmic drug withdrawal. During 3 months all patients received by turns two types of therapy: combination of preventive antiarrhythmic therapy with spirapril 6 mg once daily - (CT group) or preventive antiarrhythmic therapy only (AT group).

Results

Results. AF-free intervals to the first and the second AF paroxysms during antiarrhythmic drug withdrawal were comparable ) in AT and CT groups (p=0,4 and p=0,6, respectively, logrank test).

Conclusion

Conclusion. Spirapril added to the basic preventive antiarrhythmic therapy during 3 months had no effect on the length of interictal period in paroxysmal AF.

Цель

Цель. Оценить влияние ингибитора ангиотензинпревращающего фермента спираприла на эффективность профилактической антиаритмической терапии больных с пароксизмальной мерцательной аритмией (МА).

Материал и методы

Материал и методы. В открытое перекрестное исследование двух методов лечения с периодами полной отмены профилактической антиаритмической терапии было включено 40 пациентов с пароксизмальной МА. В течение 3 мес каждый больной получал комбинированную терапию (КТ) – профилактическую антиаритмическую терапию (ААТ) и спираприл в дозе 6 мг/сут (группа КТ) и только профилактическую ААТ (группа ААТ).

Результаты

Результаты. Периоды до первого и второго пароксизма МА после отмены ААТ были сопоставимы в группах ААТ и КТ (p=0,4 и p=0,6 соответственно, критерий logrank).

Заключение

Заключение. Использование спираприла в качестве вспомогательного средства при лечении больных с пароксизмальной МА в течение 3 мес не влияет на длительность межприступного интервала.

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The authors declare that there are no conflicts of interest present.