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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2012-8-6-777-780</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>RATIONAL PHARMACOTHERAPY IN TAKOTSUBO CARDIOMYOPATHY</article-title><trans-title-group xml:lang="ru"><trans-title>РАЦИОНАЛЬНАЯ ФАРМАКОТЕРАПИЯ ПРИ КАРДИОМИОПАТИИ ТАКОЦУБО</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марчев</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchev</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицины, исполнительный директор Болгарского Кардиологического Института, исполнительный директор специализированной больницы активного лечения в кардиологии (Плевен), член правления Болгарской ассоциацииультразвука в медицине, аккредитованный специалист по эхокардиографии Европейского Общества Кардиологов</p></bio><email xlink:type="simple">s.marchev.pn@b-c-i.eu</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Веков</surname><given-names>Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Vekov</surname><given-names>T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, председатель совета директоров Университетской клиники (Плевен), председатель совета директоров Болгарского кардиологического института, кардиологических клиник Варны, Ямбола, Велико Тырново</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Болгарский Кардиологический Институт</institution><country>Болгария</country></aff><aff xml:lang="en"><institution>Bulgarian Cardiac Institute</institution><country>Bulgaria</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2016</year></pub-date><volume>8</volume><issue>6</issue><fpage>777</fpage><lpage>780</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Marchev S., Vekov T., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Марчев С., Веков Т.</copyright-holder><copyright-holder xml:lang="en">Marchev S., Vekov T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/632">https://www.rpcardio.online/jour/article/view/632</self-uri><abstract><p>Rational pharmacotherapy in Takotsubo cardiomyopathy is based on clinical picture and data of functional and laboratory investigations of concrete patient. In patients with hypotension and moderate-to-severe left ventricle outflow tract obstruction inotropic agents must not to be used because they can worsen the degree of obstruction. In these patients beta blockers can improve hemodynamics by causing resolution of the obstruction. If intraventricular thrombus is detected, anticoagulation for at least 3 months is recommended. The duration of anticoagulant therapy may be modified depending on the extent of cardiac function recovery and thrombus resolution. For patients without thrombus but with severe left ventricular dysfunction, anticoagulation is recommended until the akinesis or dyskinesis has resolved but not more than 3 months.</p></abstract><trans-abstract xml:lang="ru"><p>Рациональная фармакотерапия при кардиомиопатии Такоцубо основывается на клинической картине, данных функциональных и лабораторных методов исследования в отношении конкретного больного. У пациентов с гипотонией и умеренной/тяжелой обструкцией выходного тракта левого желудочка сердца нельзя использовать инотропные средства, так как они могут ухудшить обструкцию. У таких пациентов применение бета-адреноблокаторов позволяет улучшить гемодинамику за счет уменьшения степени обструкции. Больным с эхокардиографическими признаками внутрижелудочкового тромбоза необходима терапия антикоагулянтами в течение не менее 3 мес. Продолжительность приема антикоагулянтов можно изменить в зависимости от степени восстановления функции левого желудочка и разрешения тромба. У больных без признаков тромбоза, но с тяжелой дисфункцией левого желудочка уместна терапия антикоагулянтами до исчезновения акинеза/дискинеза стенки левого желудочка, но не более 3 мес.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиомиопатия Такоцубо</kwd><kwd>фармакотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Тakotsubo cardiomyopathy</kwd><kwd>рharmacotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sato H, Tateishi H, Uchida T, et al. Takotsubo type cardiomyopathy due to multivessel spasm. In: Haze K, Hon M Kodama K., eds. Clinical Aspect of Myocardial Injury: From Ischaemia to Heart Failure. Tokyo: Kagakuhyouronsya; 1990: 56–64.</mixed-citation><mixed-citation xml:lang="en">Sato H, Tateishi H, Uchida T, et al. Takotsubo type cardiomyopathy due to multivessel spasm. In: Haze K, Hon M Kodama K., eds. 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