rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2011-7-1-42-48rpcardio-690Research ArticleNOTES FROM PRACTICEКЛИНИЧЕСКИЙ ОПЫТRESULTS OF TENEKTEPLASE USE IN MASSIVE PULMONARY THROMBOEMBOLISM. CLINICAL CASEРЕЗУЛЬТАТЫ ПРИМЕНЕНИЯ ТЕНЕКТЕПЛАЗЫ ПРИ МАССИВНОЙ ТРОМБОЭМБОЛИИ ЛЕГОЧНОЙ АРТЕРИИ. КЛИНИЧЕСКИЙ СЛУЧАЙРаджанР.RajanR.

врач-исследователь, старший аспирант отделения кардиологии

cardiology08@yahoo.comНатараджанР.NatarajanR.

кардиолог-интервенционист, старший консультант

ВиджейрагхаванГ.VijayaraghavanG.

руководитель отделения кардиологии, заместитель директора

Институт медицинских исследований штата Керала. Индия, ТривандрумИндияKerala Institute of Medical Sciences. P.B.No.1India201110012016714248Copyright © Rajan R., Natarajan R., Vijayaraghavan G., 20162016Раджан Р., Натараджан Р., Виджейрагхаван Г.Rajan R., Natarajan R., Vijayaraghavan G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/690

Pulmonary thromboembolism (PTE) — a life-threatening condition that can lead to death at any age. PTE — is not an independent disease, but it is a complication of venous thromboembolism. Conflicting opinions about the possibility of using tissue plasminogen activator (tenekteplase) expressed in the literature. Clinical case of the tenekteplase use in 42 years old woman with acute massive PTE and its results are described. PTE in the case was observed simultaneously with diabetic ketoacidosis. Full resolution of this thrombus according to computer pulmonary angiography was observed in patient hospitalized within 24 hours after symptom onset. This is one of the first cases of effective application of the tenekteplase in patients with massive PTE and diabetic ketoacidosis.

Тромбоэмболия легочной артерии (ТЭЛА) — это жизнеугрожающее состояние, которое может привести к летальному исходу в любом возрасте. Наиболее значимым изменением в представлениях о ТЭЛА за последние десятилетия стало понимание того, что это не самостоятельное заболевание, а осложнение венозной тромбоэмболии. В литературе высказывают противоречивое мнение о возможности применения активатора тканевого плазминогена — тенектеплазы. Описывают клинический случай применения тенектеплазы у 42-летней женщины с острой массивной ТЭЛА и его результаты. В описанном случае ТЭЛА наблюдалась одновременно с диабетическим кетоацидозом. У пациентки, госпитализированной в течение 24 ч после появления симптомов, наблюдали полное разрушение тромба по данным компьютерной ангиографии легких. Это один из первых случаев эффективного применения тенектеплазы у пациентов с массивной ТЭЛА и диабетическим кетоацидозом.

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The authors declare that there are no conflicts of interest present.