rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2011-7-1-70-74rpcardio-699Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯSUPPRESSION OF RENIN-ANGIOTENSIN SYSTEM TO PREVENT COMPLICATIONS OF CARDIOVASCULAR DISEASES: CURRENT "ROLES" DISTRIBUTION FROM CLINICAL PHARMACOLOGIST’S POINT OF VIEWПОДАВЛЕНИЕ АКТИВНОСТИ РЕНИН-АНГИОТЕНЗИНОВОЙ СИСТЕМЫ С ЦЕЛЬЮ ПРОФИЛАКТИКИ ОСЛОЖНЕНИЙ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ: СОВРЕМЕННОЕ РАСПРЕДЕЛЕНИЕ «РОЛЕЙ» С ТОЧКИ ЗРЕНИЯ КЛИНИЧЕСКОГО ФАРМАКОЛОГАГиляревскийС. Р.GilyarevskiyS. R.

д.м.н., профессор кафедры клинической фармакологии и терапии

sgilarevsky@rambler.ruОрловВ. А.OrlovV. A.

д.м.н., профессор, заведующий кафедрой клинической фармакологии и терапии

ГолшмидМ. В.GolshmidM. V.

к.м.н., доцент кафедры клинической фармакологии и терапии

ЗахароваГ. Ю.ZakharovaG. Yu.

к.м.н., доцент кафедры клинической фармакологии и терапии

СиницинаИ. И.SinitsinaI. I.

д.м.н., доцент кафедры клинической фармакологии и терапии

Российская медицинская академия последипломного образованияРоссияRussian Medical Academy of Postgraduate EducationRussian Federation201110012016717074Copyright © Gilyarevskiy S.R., Orlov V.A., Golshmid M.V., Zakharova G.Y., Sinitsina I.I., 20162016Гиляревский С.Р., Орлов В.А., Голшмид М.В., Захарова Г.Ю., Синицина И.И.Gilyarevskiy S.R., Orlov V.A., Golshmid M.V., Zakharova G.Y., Sinitsina I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/699

A role of angiotensin-converting enzyme (ACE) inhibitors in cardiovascular diseases treatment and prevention is discussed. Some large randomized clinical trials are analyzed. Physical and chemical properties of drugs and its evidence base are considered among possible factors of ACE inhibitors choice. A problem of ACE inhibitor choice is also discussed in context of secondary prevention of cardiovascular complications in arterial hypertension and after myocardial infarction. It is concluded that the choice of any drug for cardiovascular disease treatment is mainly determined by its evidence base.

Обсуждают роль ингибиторов ангиотензин-превращающего фермента (АПФ) как средств лечения и профилактики сердечно-сосудистых заболеваний. Анализируют ряд крупных рандомизированных клинических исследований. Среди возможных факторов выбора ингибиторов АПФ рассматривают физико-химические свойства препарата и его доказательную базу. Также обсуждают проблему выбора ингибитора АПФ с целью вторичной профилактики осложнений сердечно-сосудистых заболеваний при артериальной гипертонии и после перенесенного инфаркта миокарда. Приходят к выводу, что выбор любого препарата для лечения сердечно-сосудистого заболевания определяется, прежде всего, его доказательной базой.

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The authors declare that there are no conflicts of interest present.