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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2013-9-3-292-300</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>ANTICOAGULANT THERAPY IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION: DRUG CHOICE AND DOSAGE  ADJUSTMENT</article-title><trans-title-group xml:lang="ru"><trans-title>АНТИКОАГУЛЯНТНАЯ  ТЕРАПИЯ У БОЛЬНЫХ С НЕКЛАПАННОЙ ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ: ВЫБОР ПРЕПАРАТА И ПОДБОР ДОЗЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгова</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgova</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ординатор кафедры факультетской терапии лечебного факультета</p></bio><email xlink:type="simple">kateha007@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколов</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolov</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор кафедры факультетской терапии лечебного факультета</p></bio><email xlink:type="simple">kateha007@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шварц</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shvarts</surname><given-names>Yu. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, заведующий кафедрой факультетской терапии лечебного факультета</p></bio><email xlink:type="simple">kateha007@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Саратовский государственный медицинский университет имени В.И. Разумовского, Саратов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after V.I. Razumovsky, Saratov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>18</day><month>09</month><year>2015</year></pub-date><volume>9</volume><issue>3</issue><fpage>292</fpage><lpage>300</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dolgova E.L., Sokolov I.M., Shvarts Y.G., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Долгова Е.Л., Соколов И.М., Шварц Ю.Г.</copyright-holder><copyright-holder xml:lang="en">Dolgova E.L., Sokolov I.M., Shvarts Y.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/7">https://www.rpcardio.online/jour/article/view/7</self-uri><abstract><p>Data on the problem of thromboembolic complications in non-valvular atrial fibrillation are presented. Peculiarities of anticoagulant therapy to prevent thromboembolic complications, the difficulties in drug choice and dosage adjustment are also discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены данные литературы об актуальности проблемы тромбоэмболических осложнений при неклапанной фибрилляции предсердий, об особенностях антикоагулянтной терапии при данной патологии и трудностях, возникающих при выборе препарата для профилактики тромбоэмболических осложнений.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>тромбоэмболические осложнения</kwd><kwd>антикоагулянтная терапия</kwd><kwd>варфарин</kwd><kwd>апиксабан</kwd><kwd>ривароксабан</kwd><kwd>дабигатран</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>thromboembolic complications</kwd><kwd>anticoagulant therapy</kwd><kwd>warfarin</kwd><kwd>apixaban</kwd><kwd>rivaroxaban</kwd><kwd>dabigatran</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lip G.Y, Nieuwlaat R., Pisters R., Lane D.A., Crijns H.J. 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