rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2011-7-1-82-88rpcardio-704Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИNEW ANTIPLATELET DRUGS (PART 1)НОВЫЕ ДЕЗАГРЕГАНТНЫЕ ПРЕПАРАТЫ (ЧАСТЬ 1)СумароковА. Б.SumarokovA. B.

к.м.н., старший научный сотрудник отдела проблем атеросклероза

Vokoramus@mail.ruИнститут кардиологии им А.Л. Мясникова, Российский кардиологический научно-производственный комплексРоссияInstitute for Cardiology named after A.L. Mjasnikov, Russian Cardiology Research and Production ComplexRussian Federation201110012016718288Copyright © Sumarokov A.B., 20162016Сумароков А.Б.Sumarokov A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/704

Antiplatelet agents are a necessary component of modern atherosclerosis therapy. The difficulties of antiplatelet treatment lie in the balance between the necessary therapeutic effect of the drug and the risk of excessive action leading to the bleeding. Possibility to control pharmacodynamics effects of antiplatelet agents is still very limited. Pharmacology of antiplatelet drugs is growing rapidly. Some of new antiplatelet drugs are on their way to clinical application — prasugrel, ticagrelor, elinogrel, inhibitors of thromboxane and thrombin receptors. Clinical pharmacology of these drugs is different. This requires a doctor's good knowledge of their identity to avoid the development of iatrogenic complications.

Дезагреганты являются обязательным компонентом современной терапии атеросклероза. Трудности лечения дезагрегантами заключаются в балансировании между необходимым терапевтическим эффектом препарата и риском избыточного действия, приводящего к кровотечениям. Возможность контролировать фармакодинамические эффекты дезагрегантов пока ещё очень ограниченна. Фармакология дезагрегантов стремительно развивается. Ряд новейших дезагрегантов находится на подходе к клиническому применению — прасугрел, тикагрелор, элиногрел, ингибиторы тромбоксановых и тромбиновых рецепторов. Клиническая фармакология этих препаратов имеет различия, что требует от врача хорошего знания их особенностей во избежание развития ятрогенных осложнений.

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The authors declare that there are no conflicts of interest present.