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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2010-6-1-103-107</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-778</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>THE BISOPROLOL — A HIGH SELECTIVE BETA-BLOCKER ACCORDING TO EVIDENCE BASED MEDICINE</article-title><trans-title-group xml:lang="ru"><trans-title>БИСОПРОЛОЛ — ВЫСОКОСЕЛЕКТИВНЫЙ БЕТА-АДРЕНОБЛОКАТОР С ПОЗИЦИИ ДОКАЗАТЕЛЬНОЙ МЕДИЦИНЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукина</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukina</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ст.н.с. отдела профилактической фармакотерапии</p><p>ассистент кафедры доказательной медицины ММА</p><p>101990 Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Petroverigsky per. 10, Moscow, 101990</p></bio><email xlink:type="simple">jlukina@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марцевич</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Martsevich</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, руководитель отдела профилактической фармакотерапии</p><p>профессор кафедры доказательной медицины ММА</p><p>101990 Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины Росмедтехнологий</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Center for Preventive Medicine of Rosmedtechnology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>01</month><year>2016</year></pub-date><volume>6</volume><issue>1</issue><fpage>103</fpage><lpage>107</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Lukina Y.V., Martsevich S.Y., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Лукина Ю.В., Марцевич С.Ю.</copyright-holder><copyright-holder xml:lang="en">Lukina Y.V., Martsevich S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/778">https://www.rpcardio.online/jour/article/view/778</self-uri><abstract><p>Data of the evidence based medicine about bisoprolol treatment of patients with cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure, rhythm disorders) are presented. Implementation of bisoprolol generics as well as bisoprolol usage in smoking cardiovascular patients is also discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Рассматриваются данные доказательной медицины по селективному бета-адреноблокатору бисопрололу, обосновывающие применение этого препарата у пациентов с различными сердечно-сосудистыми заболеваниями: артериальной гипертонией, ишемической болезнью сердца, хронической сердечной недостаточностью, нарушениями сердечного ритма. В дополнительных разделах обсуждаются вопросы использования дженериков бисопролола, а также применение данного бета-адреноблокатора у курящих пациентов с сердечно-сосудистыми заболеваниями.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бета-адреноблокаторы</kwd><kwd>бисопролол</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>beta-blockers</kwd><kwd>bisoprolol</kwd><kwd>cardiovascular diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств.3-е изд., перераб. и доп. М.: МИА; 2005.</mixed-citation><mixed-citation xml:lang="en">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств.3-е изд., перераб. и доп. 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