rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-3-301-305rpcardio-8Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИTRUE RESISTANCE AND PSEUDORESISTANCE TO ASPIRINАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ ИСТИННАЯ РЕЗИСТЕНТНОСТЬ И ПСЕВДОРЕЗИСТЕНТНОСТЬ К АСПИРИНУМартыновА. И.MartynovA. I.

Доктор медицинских наук, профессор кафедры госпитальной терапии №1, академик Российской академии медицинских наук

akev@list.ruАкатоваЕ. В.AkatovaE. V.

Доктор медицинских наук, профессор кафедры госпитальной терапии №1

akev@list.ruУрлаеваИ. В.UrlayevaI. V.

Аспирант кафедры госпитальной терапии №1

akev@list.ruНиколинО. П.NicolinO. P.

Кандидат медицинских наук,  ассистент кафедры госпитальной терапии №1

akev@list.ruМосковский государственный медико-стоматологический университет им. А.И. Евдокимова, МоскваРоссияMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, MoscowRussian Federation20131809201593301305Copyright © Martynov A.I., Akatova E.V., Urlayeva I.V., Nicolin O.P., 20152015Мартынов А.И., Акатова Е.В., Урлаева И.В., Николин О.П.Martynov A.I., Akatova E.V., Urlayeva I.V., Nicolin O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/8

Low dose aspirin reduces the secondary incidence of myocardial infarction and stroke. Drug resistance to aspirin might result in treatment failure. Despite this concern, no clear definition of aspirin resistance has emerged, and estimates of its incidence have varied remarkably. Researchers from university of Pennsylvania (Philadelphia, the USA), led by Dr. Tilo Grosser, aimed to determine the specific phenotype of true pharmacological resistance to aspirin — such as might be explained by genetic causes. However the study failed to identify a single case of true drug resistance. Pseudoresistance, reflecting delayed and reduced drug absorption, complicates enteric coated but not immediate release aspirin administration.

Низкая доза аспирина уменьшает риск развития повторного инфаркта миокарда и инсульта. Резистентность к аспирину может снизить эффективность лечения, именно поэтому данный вопрос обращает на себя все большее внимание. Группа ученых из университета Пенсильвании (Филадельфия, США) во главе с доктором Tilo Grosser поставила цель определить генетически обусловленный механизм развития устойчивости к аспирину и выявить специфический фенотип истинной фармакологической резистентности к аспирину. Однако в ходе исследования не было выявлено ни одного случая истинной лекарственной резистентности. Псевдорезистентность была вызвана исключительно кишечнорастворимой оболочкой таблетки аспирина.

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The authors declare that there are no conflicts of interest present.