<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2011-7-3-342-346</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-808</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>STROKE PREVENTION IN INTERNIST PRACTICE</article-title><trans-title-group xml:lang="ru"><trans-title>ПРОФИЛАКТИКА ИНСУЛЬТА В ПРАКТИКЕ ИНТЕРНИСТА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Напалков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Napalkov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры факультетской терапии № 1 лечебного факультета</p></bio><email xlink:type="simple">dminap@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жиленко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhilenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач клинико-диагностического отделения университетской клинической больницы № 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Setchenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>17</day><month>01</month><year>2016</year></pub-date><volume>7</volume><issue>3</issue><fpage>342</fpage><lpage>346</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Napalkov D.A., Zhilenko A.V., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Напалков Д.А., Жиленко А.В.</copyright-holder><copyright-holder xml:lang="en">Napalkov D.A., Zhilenko A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/808">https://www.rpcardio.online/jour/article/view/808</self-uri><abstract><p>Stroke secondary prevention in internist practice is discussed in accordance with up to date guidelines. Modern pharmacotherapy includes antiaggregants or anticoagulants, statins, and antihypertensive drugs. The choice of drugs is mostly founded on the rules of evidence based medicine, which allow adjusting individual treatment depending on clinical conditions. The composition of perindopril and indapamide is a preferred nowadays combination of antihypertensive drugs.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются вопросы вторичной профилактики инсульта в общей  врачебной практике в соответствии с требованиями современных рекомендаций. Современная фармакотерапия включает антиагреганты или антикоагулянты, статины и антигипертензивные препараты. Выбор лекарственных средств в большинстве случаев основывается на принципах доказательной медицины, позволяющих подбирать индивидуальное лечение в зависимости от конкретной клинической ситуации. Комбинацией выбора из числа антигипертензивных препаратов в настоящее время считают сочетание периндоприла и индапамида.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инсульт</kwd><kwd>вторичная профилактика</kwd><kwd>антиагреганты</kwd><kwd>антикоагулянты</kwd><kwd>статины</kwd><kwd>артериальная гипертензия</kwd><kwd>периндоприл</kwd><kwd>индапамид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke</kwd><kwd>secondary prevention</kwd><kwd>antiaggregants</kwd><kwd>anticoagulants</kwd><kwd>statins</kwd><kwd>arterial hypertension</kwd><kwd>perindopril</kwd><kwd>indapamide</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO atlas of heart disease and stroke. Available on: http://www.who.int/cardiovascular_diseases/en/cvd_atlas_15_burden_stroke.pdf. Accessed July 8, 2009.</mixed-citation><mixed-citation xml:lang="en">WHO atlas of heart disease and stroke. Available on: http://www.who.int/cardiovascular_diseases/en/cvd_atlas_15_burden_stroke.pdf. Accessed July 8, 2009.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Truelsen T., Piechowski-Jу wiak B., Bonita R., Mathers C., Bogousslavsky J., Boysen G. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol 2006; 13(6): 581–598.</mixed-citation><mixed-citation xml:lang="en">Truelsen T., Piechowski-Jу wiak B., Bonita R., Mathers C., Bogousslavsky J., Boysen G. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol 2006; 13(6): 581–598.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Paul S.L., Srikanth V.K., Thrift A.G. The large and growing burden of stroke. Curr Drug Targets 2007; 8(7): 786–793.</mixed-citation><mixed-citation xml:lang="en">Paul S.L., Srikanth V.K., Thrift A.G. The large and growing burden of stroke. Curr Drug Targets 2007; 8(7): 786–793.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Coull A.J., Lovett J.K., Rothwell P.M. Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ 2004; 328(7435): 326.</mixed-citation><mixed-citation xml:lang="en">Coull A.J., Lovett J.K., Rothwell P.M. Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ 2004; 328(7435): 326.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Weisman S.M. and Graham D.Y. Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Archives of Internal Medicine 2002; 162 (19): 2197–2202.</mixed-citation><mixed-citation xml:lang="en">Weisman S.M. and Graham D.Y. Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Archives of Internal Medicine 2002; 162 (19): 2197–2202.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Z.M. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 1997; 349 (9066): 1641–1649.</mixed-citation><mixed-citation xml:lang="en">Chen Z.M. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 1997; 349 (9066): 1641–1649.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Z., Sandercock P., Pan H. et al. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial. Stroke 2000; 31 (6): 1240–1249.</mixed-citation><mixed-citation xml:lang="en">Chen Z., Sandercock P., Pan H. et al. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial. Stroke 2000; 31 (6): 1240–1249.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">International Stroke Trial collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. Lancet 1997; 349 (9065): 1569–1581.</mixed-citation><mixed-citation xml:lang="en">International Stroke Trial collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. Lancet 1997; 349 (9065): 1569–1581.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Patrono C. and Rocca B. Aspirin: promise and resistance in the new millennium. Arteriosclerosis, Thrombosis, and Vascular Biology 2008; 28 (3): s25–s32.</mixed-citation><mixed-citation xml:lang="en">Patrono C. and Rocca B. Aspirin: promise and resistance in the new millennium. Arteriosclerosis, Thrombosis, and Vascular Biology 2008; 28 (3): s25–s32.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Diener H.C., Cunha L., Forbes C., Sivenius J., Smets P. and Lowenthal A. European stroke prevention study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neur Sci 1996; 143 (1-2): 1–13.</mixed-citation><mixed-citation xml:lang="en">Diener H.C., Cunha L., Forbes C., Sivenius J., Smets P. and Lowenthal A. European stroke prevention study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neur Sci 1996; 143 (1-2): 1–13.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Halkes P.H., van Gijn J., Kappelle L.J., Koudstaal P.J and Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomized controlled trial. Lancet, 2006; 367: 1665–1673.</mixed-citation><mixed-citation xml:lang="en">Halkes P.H., van Gijn J., Kappelle L.J., Koudstaal P.J and Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomized controlled trial. Lancet, 2006; 367: 1665–1673.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sacco R.L., Diener H.-C., Yusuf S. et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New Engl J Med 2008; 359 (12): 1238–1251.</mixed-citation><mixed-citation xml:lang="en">Sacco R.L., Diener H.-C., Yusuf S. et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New Engl J Med 2008; 359 (12): 1238–1251.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gent M. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348 (9038): 1329–1339.</mixed-citation><mixed-citation xml:lang="en">Gent M. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348 (9038): 1329–1339.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Diener H.C., Bogousslavsky J., Brass L.M. et al. MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomized, doubleblind, placebo-controlled trial. Lancet, 2004; 364 (9431): 331–337.</mixed-citation><mixed-citation xml:lang="en">Diener H.C., Bogousslavsky J., Brass L.M. et al. MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomized, doubleblind, placebo-controlled trial. Lancet, 2004; 364 (9431): 331–337.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt B.L. and Topol E.J. Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: rationale and design of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial. Am Heart J 2004; 148 (2): 263–268.</mixed-citation><mixed-citation xml:lang="en">Bhatt B.L. and Topol E.J. Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: rationale and design of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial. Am Heart J 2004; 148 (2): 263–268.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S.J., Pogue J., Hart R.G. et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. New Engl J Med 2009; 360 (20): 2066–2078.</mixed-citation><mixed-citation xml:lang="en">Connolly S.J., Pogue J., Hart R.G. et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. New Engl J Med 2009; 360 (20): 2066–2078.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Fuster V., Rydén L.E., Cannom D.S. et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2007; 116 (6): e138.</mixed-citation><mixed-citation xml:lang="en">Fuster V., Rydén L.E., Cannom D.S. et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2007; 116 (6): e138.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Samsa G.P., Matchar D.B., Goldstein L.B. et al. Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities. Arch Intern Med 2000; 160: 967-73.</mixed-citation><mixed-citation xml:lang="en">Samsa G.P., Matchar D.B., Goldstein L.B. et al. Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities. Arch Intern Med 2000; 160: 967-73.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Amarenco P., Lavallëe P.C., Mazighi M., Labreuche J. Statins in stroke prevention. Future Lipidology 2008; 3(3): 319-325.</mixed-citation><mixed-citation xml:lang="en">Amarenco P., Lavallëe P.C., Mazighi M., Labreuche J. Statins in stroke prevention. Future Lipidology 2008; 3(3): 319-325.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Amarenco P., Bogousslavsky J., Callahan A. 3rd et al. for the SPARCL Investigators. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355 (6): 549-555.</mixed-citation><mixed-citation xml:lang="en">Amarenco P., Bogousslavsky J., Callahan A. 3rd et al. for the SPARCL Investigators. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355 (6): 549-555.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Furie K.L., Kasner S.E., Adams R.J. et al. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2011; 42:00-00.</mixed-citation><mixed-citation xml:lang="en">Furie K.L., Kasner S.E., Adams R.J. et al. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2011; 42:00-00.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">PROGRESS Management Committee. Blood pressure lowering for the secondary prevention of stroke: rationale and design for PROGRESS (Perindopril Protection Against Recurrent Stroke Study). J Hypertens Suppl 1996; 14 (2): 41-45.</mixed-citation><mixed-citation xml:lang="en">PROGRESS Management Committee. Blood pressure lowering for the secondary prevention of stroke: rationale and design for PROGRESS (Perindopril Protection Against Recurrent Stroke Study). J Hypertens Suppl 1996; 14 (2): 41-45.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
