rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2011-7-3-365-370rpcardio-811Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИVALUE OF NICOTINIC ACID IN THE CURRENT CARDIOLOGYЗНАЧЕНИЕ НИКОТИНОВОЙ КИСЛОТЫ В СОВРЕМЕННОЙ КАРДИОЛОГИИТрухачеваЕ. П.TrukhachevaE. P.

аспирант отдела проблем атеросклероза Института клинической кардиологии им. А.Л. Мясникова

ЕжовМ. В.EzhovM. V.

д.м.н., отдела проблем атеросклероза Института клинической кардиологии им. А.Л. Мясникова

marat_ezhov@mail.ruФГУ «Российский кардиологический научно-производственный комплекс» МЗ и СР РФРоссияRussian Cardiology Research and Production ComplexRussian Federation20111701201673365370Copyright © Trukhacheva E.P., Ezhov M.V., 20162016Трухачева Е.П., Ежов М.В.Trukhacheva E.P., Ezhov M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/811

Statin intake is a standard in the treatment of patients with atherosclerosis nowadays. These drugs therapy associates with 30% risk reduction in mortality and coronary events. However , the threat of recurrent events is sufficiently high in large part of patients. This can be related to low level of high density lipoprotein cholesterol as well as elevated levels of triglycerides and lipoprotein(a). Nicotinic acid intake in these patients may be necessary for the normalization of lipid profile, including lipoprotein(a), and will be able to reduce residual cardiovascular risk. Evidence-based medicine data are presented to prove an efficacy of nicotinic acid in high doses in cardiology practice. Nicotinic acid both in monotherapy and in combination with statins contributes to coronary and carotid atherosclerosis regression and reduces an incidence of cardiovascular complications. Long-acting formulation of nicotinic acid, correct receiving regime and blood bio-chemical monitoring contribute to long-term safety of the drug in patients with clinically significant atherosclerosis.

На сегодняшний день стандартом в лечении больных атеросклерозом является применение статинов. Назначение препаратов этой группы ассоциируется со снижением риска смертности и коронарных осложнений на 30%. Однако у существенной доли пациентов угроза развития повторных событий достаточна высока. Это может быть связано с тем, что у многих пациентов сохраняется сниженный уровень холестерина липопротеидов высокой плотности, повышенная концентрация триглицеридов и липопротеида(а). Применение никотиновой кислоты у такой категории больных может быть необходимым для нормализации всех показателей липидного профиля, включая липопротеид(а), что позволит в какой-то степени добиться снижения резидуального риска. Приводятся данные доказательной медицины, подтверждающие эффективность высоких доз никотиновой кислоты в кардиологической практике. Показано, что никотиновая кислота как в монотерапии, так и в комбинации со статинами способствует регрессии коронарного и каротидного атеросклероза и снижению частоты сердечно-сосудистых осложнений. Пролонгированные формы никотиновой кислоты, правильный режим приема и регулярный контроль биохимических параметров крови способствуют длительному и безопасному применению препарата у больных с клинически значимым атеросклерозом.

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The authors declare that there are no conflicts of interest present.