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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2010-6-3-349-358</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-878</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL DISCUSSION</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ РАЗБОР</subject></subj-group></article-categories><title-group><article-title>RHEUMATIC FEVER AS NONVANISHING DISEASE: A PROBLEM STATE AND CLINICAL CASES</article-title><trans-title-group xml:lang="ru"><trans-title>РЕВМАТИЧЕСКАЯ ЛИХОРАДКА — НЕИСЧЕЗАЮЩЕЕ ЗАБОЛЕВАНИЕ: СОСТОЯНИЕ ВОПРОСА, КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая кафедрой </p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова </p><p>117997 Москва, ул. Островитянинова, 1</p></bio><bio xml:lang="en"><p>Chair of Faculty Therapy named after academician A.I. Nesterov</p><p>Ostrovityaninova ul. 1, Moscow, 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клименко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент </p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова </p><p>117997 Москва, ул. Островитянинова, 1</p></bio><bio xml:lang="en"><p>Chair of Faculty Therapy named after academician A.I. Nesterov</p><p>Ostrovityaninova ul. 1, Moscow, 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новиков</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова </p><p>117997 Москва, ул. Островитянинова, 1</p></bio><bio xml:lang="en"><p>Chair of Faculty Therapy named after academician A.I. Nesterov</p><p>Ostrovityaninova ul. 1, Moscow, 117997 </p></bio><email xlink:type="simple">hilfswillige@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андрияшкина</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Andrijashkina</surname><given-names>D. J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент </p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова </p><p>117997 Москва, ул. Островитянинова, 1</p></bio><bio xml:lang="en"><p>Chair of Faculty Therapy named after academician A.I. Nesterov</p><p>Ostrovityaninova ul. 1, Moscow, 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чурилова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Churilova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор </p><p>Кафедра факультетской терапии им. акад. А.И. Нестерова </p><p>117997 Москва, ул. Островитянинова, 1</p></bio><bio xml:lang="en"><p>Chair of Faculty Therapy named after academician A.I. Nesterov</p><p>Ostrovityaninova ul. 1, Moscow, 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2016</year></pub-date><volume>6</volume><issue>3</issue><fpage>349</fpage><lpage>358</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shostak N.A., Klimenko A.A., Novikov I.V., Andrijashkina D.J., Churilova M.S., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Шостак Н.А., Клименко А.А., Новиков И.В., Андрияшкина Д.Ю., Чурилова М.С.</copyright-holder><copyright-holder xml:lang="en">Shostak N.A., Klimenko A.A., Novikov I.V., Andrijashkina D.J., Churilova M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/878">https://www.rpcardio.online/jour/article/view/878</self-uri><abstract><p>Early diagnostics and treatment of patients with acute rheumatic fever (RF) remains actual problem because rheumatic heart disease is still one of the main causes of acquired valvular lesions. Two cases of acute RF occurred in City Clinical Hospital №1 named after N.I. Pirogov in 2009 are presented. Different outcomes were observed during 6 and 10 months of clinical monitoring. The main approaches to diagnostics and treatment of RF are also described taking into consideration national and international guidelines.</p></abstract><trans-abstract xml:lang="ru"><p>Проблема своевременной диагностики и адекватного лечения больных с ревматической лихорадкой (РЛ) по-прежнему является актуальной в современной медицине в силу того, что именно хроническая ревматическая болезнь сердца продолжает занимать одно из ведущих мест в генезе приобретенных пороков сердца. Представлены 2 клинических случая заболевания острой РЛ, зарегистрированные в 2009 г в Городской клинической больнице №1 им. Н.И.Пирогова Москвы. Отмечены различные исходы заболевания при наблюдении в течение 6 и 10 мес. Также описаны основные подходы к диагностике и лечению РЛ с учетом современных отечественных и зарубежных рекомендаций.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острая ревматическая лихорадка</kwd><kwd>бета-гемолитический стрептококк</kwd><kwd>критерии диагностики</kwd><kwd>ревматический вальвулит</kwd><kwd>ревматический полиартрит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute rheumatic fever</kwd><kwd>beta-haemolytic streptococcus</kwd><kwd>diagnostic criteria</kwd><kwd>rheumatic valvulitis</kwd><kwd>rheumatic polyarthritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анохин В.Н., Новиков Ю.И., Стулова М.А. Современные представления о патогенезе ревматизма. Вопросы ревматизма 1980;2:3-7.</mixed-citation><mixed-citation xml:lang="en">Анохин В.Н., Новиков Ю.И., Стулова М.А. Современные представления о патогенезе ревматизма. 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