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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2010-6-4-46-52</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-898</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>RECENT ADVANCES IN THE APPLICATION OF HIGH DOSES OF ATORVASTATIN IN PATIENTS WITH CORONARY HEART DISEASE</article-title><trans-title-group xml:lang="ru"><trans-title>ПОСЛЕДНИЕ ДОСТИЖЕНИЯ В ПРИМЕНЕНИИ ВЫСОКИХ ДОЗ АТОРВАСТАТИНА У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ежов</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ezhov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., н.с. отдела проблем атеросклероза Института клинической кардиологии им А.Л. Мясникова </p><p>121552, Москва, 3-я Черепковская ул., 15а</p></bio><bio xml:lang="en"><p>Tretya Cherepkovskaya ul. 15a, Moscow, 121552</p></bio><email xlink:type="simple">marat_ezhov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский кардиологический научно-производственный комплекс</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Cardiology Research and Production Complex</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2016</year></pub-date><volume>6</volume><issue>4</issue><fpage>573</fpage><lpage>577</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ezhov M.V., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Ежов М.В.</copyright-holder><copyright-holder xml:lang="en">Ezhov M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/898">https://www.rpcardio.online/jour/article/view/898</self-uri><abstract><p>The results of the recently completed clinical studies on the efficacy of atorvastatin in high doses are presented. In these studies high dose atorvastatin therapy was used in patients with acute coronary syndrome, chronic coronary heart disease, and percutaneous coronary interventions. Studies completed in Russia and devoted to efficacy of the high dose atorvastatin therapy are discussed specially.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены результаты исследований последних лет по эффективности высоких доз аторвастатина при остром коронарном синдроме, хронической ишемической болезни сердца чрескожных коронарных вмешательствах. Специально обсуждаются результаты проведенных в России исследований эффективности высоких доз аторвастатина.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аторвастатин</kwd><kwd>высокие дозы</kwd><kwd>острый коронарный синдром</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>чрескожные коронарные вмешательства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atorvastatin</kwd><kwd>high doses</kwd><kwd>acute coronary syndrome</kwd><kwd>coronary heart disease</kwd><kwd>percutaneous coronary interventions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">BodenW.E., O'Rourke R.A., TeoK.K. et al. COURAGE Trial Research Group. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007;356(15):1503-1516.</mixed-citation><mixed-citation xml:lang="en">BodenW.E., O'Rourke R.A., TeoK.K. et al. COURAGE Trial Research Group. 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