rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2010-6-6-837-842rpcardio-929Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯTENEKTEPLASE: NEW POSSIBILITIES FOR SYSTEMIC THROMBOLYTIC THERAPY OF ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATIONТЕНЕКТЕПЛАЗА: НОВЫЕ ВОЗМОЖНОСТИ СИСТЕМНОЙ ТРОМБОЛИТИЧЕСКОЙ ТЕРАПИИ ПРИ ОСТРОМ КОРОНАРНОМ СИНДРОМЕ С ПОДЪЕМОМ СЕГМЕНТА STНовиковаН. А.NovikovaN. A.

д.м.н., профессор кафедры профилактической и неотложной кардиологии ФППОВ

119992, Москва, Трубецкая ул., д. 8, стр. 2

Trubetskaya ul. 8-2, Moscow, 119991

nanovikova@mail.ruУдовиченкоА. Е.UdovichenkoA. E.

к.м.н., врач анестезиолог- реаниматолог отделения реанимации и интенсивной терапии Первой Университетской клинической больницы 

119992, Москва, Трубецкая ул., д. 8, стр. 2

Trubetskaya ul. 8-2, Moscow, 119991

Первый Московский Государственный Медицинский Университет им. И.М. СеченоваРоссияI.M. Setchenov First Moscow State Medical UniversityRussian Federation20102001201666837842Copyright © Novikova N.A., Udovichenko A.E., 20162016Новикова Н.А., Удовиченко А.Е.Novikova N.A., Udovichenko A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/929

Possibilities to use and advantages of a new tissue plasminogen activator (tenekteplase) in patients with acute coronary syndrome (ACS) with ST segment elevation are discussed. The main factor of tenekteplase successful implementation is the time. Comparative studies of tenekteplase and other tissue plasminogen activator are presented. Efficacy of thrombolytic therapy and percutaneous coronary interventions is compared. Data from multicenter randomized clinical trials about combined use of tenekteplase and enoxaparin and unfractionated heparin in the hospital is discussed. Data about safety of tenekteplase in treatment of ACS with ST segment elevation is given.

Обсуждают возможности и преимущества применения нового тканевого активатора плазминогена — тенектеплазы у пациентов с острым коронарным синдромом (ОКС) с подъемом сегмента ST. Основным фактором ее успешного применения является время. Подробно освещены сравнительные исследования тенектеплазы с другим тканевым активатором плазминогена. Сравнивают эффективность тромболитической терапии и чрескожных коронарных вмешательств. Приводят данные многоцентровых рандомизированных клинических исследований о возможности сочетания тенектеплазы с эноксапарином и нефракционированным гепарином в стационаре. Представлены данные по безопасности применения тенектеплазы при лечении ОКС с подъемом сегмента ST.

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The authors declare that there are no conflicts of interest present.