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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2011-7-5-613-619</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-936</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>СHOICE OF ZOFENOPRIL AND HYDROCHLOROTHIAZIDE COMBINATION IN THE TREATMENT OF ARTERIAL HYPERTENSION</article-title><trans-title-group xml:lang="ru"><trans-title>ВЫБОР КОМБИНАЦИИ ЗОФЕНОПРИЛА И ГИДРОХЛОРОТИАЗИДА ПРИ ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джаиани</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhaiani</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры скорой медицинской помощи</p></bio><email xlink:type="simple">doctorni@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский Государственный медико-стоматологический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2016</year></pub-date><volume>7</volume><issue>5</issue><fpage>613</fpage><lpage>619</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dzhaiani N.A., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Джаиани Н.А.</copyright-holder><copyright-holder xml:lang="en">Dzhaiani N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/936">https://www.rpcardio.online/jour/article/view/936</self-uri><abstract><p>Problems of antihypertensive therapy are discussed in the light of the present epidemiological situation with arterial hypertension. ACE inhibitors have a special place among the antihypertensive drugs. Advantages and evidence base of ACE inhibitors representative — zofеnopril highlighted. Special attention is given to combined antihypertensive therapy , particularly combination of zofenopril and hydrochlorothiazide.</p></abstract><trans-abstract xml:lang="ru"><p>Рассматриваются вопросы антигипертензивной терапии с учетом настоящей эпидемиологической ситуации по артериальной гипертонии. Среди антигипертензивных препаратов особое место занимают ингибиторы АПФ. Обсуждаются преимущества и доказательная база представителя ингибиторов АПФ зофеноприла. Особое внимание уделяется комбинированной антигипертензивной терапии, в частности комбинации зофеноприла и гидрохлоротиазида.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>комбинированная терапия</kwd><kwd>зофеноприл</kwd><kwd>гидрохлоротиазид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>combined therapy</kwd><kwd>zofenopril</kwd><kwd>hydrochlorothiazide</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kearney P.M., Whelton M., Reynolds K. et al. Global burden of hypertension: analysis of worldwide data. The Lancet 2005; 365: 217-223.</mixed-citation><mixed-citation xml:lang="en">Kearney P.M., Whelton M., Reynolds K. et al. Global burden of hypertension: analysis of worldwide data. 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