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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2011-7-5-628-636</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-939</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>ANTITHROMBOTIC THERAPY IN ATRIAL FIBRILLATION: RECENT APPROACHES AND NEAR PERSPECTIVES</article-title><trans-title-group xml:lang="ru"><trans-title>АНТИТРОМБОТИЧЕСКАЯ ТЕРАПИЯ ПРИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ: СОВРЕМЕННЫЕ ПОДХОДЫ И БЛИЖАЙШИЕ ПЕРСПЕКТИВЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Довгалевский</surname><given-names>Я. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Dovgalevskiy</surname><given-names>Ya. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующий лабораторией атеросклероза и хронической ишемической болезни сердца</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кувшинова</surname><given-names>Л. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuvshinova</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор</p></bio><email xlink:type="simple">l.e.kuvshinova@gmail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грайфер</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Graifer</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фурман</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Furman</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующий лабораторией неотложной кардиологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Довгалевский</surname><given-names>П. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Dovgalevskiy</surname><given-names>P. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, директор</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Саратовский Научно-исследовательский институт кардиологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov Research Institute for Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2016</year></pub-date><volume>7</volume><issue>5</issue><fpage>628</fpage><lpage>636</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dovgalevskiy Y.P., Kuvshinova L.E., Graifer I.V., Furman N.V., Dovgalevskiy P.Y., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Довгалевский Я.П., Кувшинова Л.Е., Грайфер И.В., Фурман Н.В., Довгалевский П.Я.</copyright-holder><copyright-holder xml:lang="en">Dovgalevskiy Y.P., Kuvshinova L.E., Graifer I.V., Furman N.V., Dovgalevskiy P.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/939">https://www.rpcardio.online/jour/article/view/939</self-uri><abstract><p>Recent data and perspectives of antithrombotic therapy in patients with atrial fibrillation (AF) are highlighted. The main statements of current Russian and international guidelines about thromboembolic events prevention in AF patients are presented. Special attention paid to new agents for oral anticoagulation therapy , last information about their efficacy , safety and potential of application.</p></abstract><trans-abstract xml:lang="ru"><p>Освещены современные данные и перспективы антитромботической терапии у больных фибрилляцией предсердий (ФП). Приведены данные последних отечественных и зарубежных рекомендаций по профилактике тромбоэмболических осложнений при ФП. Отдельно рассмотрены новые препараты для проведения оральной антикоагулянтной терапии, представлены сведения об их эффективности, безопасности и возможностях использования.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>антитромботическая терапия</kwd><kwd>оральные антикоагулянты</kwd><kwd>дабигатран</kwd><kwd>ривароксабан</kwd><kwd>апиксабан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>antithrombotic therapy</kwd><kwd>oral anticoagulants</kwd><kwd>dabigatran</kwd><kwd>rivaroxaban</kwd><kwd>apixaban</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Camm A.J., Kirchhof P., Lip G.Y. et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). 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