rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2011-7-5-637-643rpcardio-940Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИNEW ANTIPLATELET DRUGS. PART 2НОВЫЕ ДЕЗАГРЕГАНТНЫЕ ПРЕПАРАТЫ. ЧАСТЬ 2СумароковА. Б.SumarokovA. B.

к.м.н., с.н.с. отдела проблем атеросклероза 

Vokoramus@mail.ruИнститут кардиологии им А.Л. Мясникова, Российский кардиологический научно-производственный комплексРоссияInstitute for Cardiology named after A.L. Mjasnikov , Russian Cardiology Research and Production ComplexRussian Federation20112101201675637643Copyright © Sumarokov A.B., 20162016Сумароков А.Б.Sumarokov A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/940

Antiplatelet agents are a necessary component of modern therapy of atherosclerosis. The difficulties of the antiplatelet treatment lie in balance between the necessary therapeutic effect and the risk of excessive action, leads to the bleeding. The ability to monitor antiplatelet pharmacodynamics is still very limited. Pharmacology of antiplatelet drug has been developing rapidly. New antiplatelet drugs are on their way to clinical application — prasugrel, ticagrelor , elinogrel, thromboxane receptor inhibitors, thrombin receptors inhibitors. Clinical pharmacology of these drugs is different. Practitioner should know their specifics to avoid the development of iatrogenic complications.

Дезагреганты являются обязательным компонентом современной терапии атеросклероза. Трудности лечения дезагрегантами заключаются в балансировании между необходимым терапевтическим эффектом и риском избыточного действия, приводящего к кровотечениям. Возможности отслеживать фармакодинамику дезагрегантов пока ещё очень ограниченны. Фармакология дезагрегантов стремительно развивается. Целая серия новейших дезагрегантов находится на подходе к клиническому применению — прасугрел, тикагрелор, элиногрел, ингибиторы тромбоксановых рецепторов, ингибиторы тромбиновых рецепторов. Клиническая фармакология этих препаратов имеет различия, что требует от врача хорошего знания их особенностей во избежание развития ятрогенных осложнений.

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The authors declare that there are no conflicts of interest present.