<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2010-6-5-685-690</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-968</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>THE INVASIVE DENTAL PROCEDURES IN PATIENTS TREATING WITH WARFARIN: POSSIBILITIES AND PROSPECTS FOR SAFETY</article-title><trans-title-group xml:lang="ru"><trans-title>ИНВАЗИВНЫЕ СТОМАТОЛОГИЧЕСКИЕ ПРОЦЕДУРЫ У БОЛЬНЫХ, ПРИНИМАЮЩИХ ВАРФАРИН: ВОЗМОЖНОСТИ И ПЕРСПЕКТИВЫ БЕЗОПАСНОСТИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., доцент кафедры госпитальной терапии №1 </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Trubetskaya ul. 8/2, Moscow, 119991</p></bio><email xlink:type="simple">dockozlova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макеева</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Makeyeva</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. кафедрой терапевтической стоматологии </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Trubetskaya ul. 8/2, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорошина</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Doroshina</surname><given-names>V. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Trubetskaya ul. 8/2, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бокарева</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Bokareva</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка 5-го курса стоматологического факультета </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Trubetskaya ul. 8/2, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский Государственный Медицинский Университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2016</year></pub-date><volume>6</volume><issue>5</issue><fpage>685</fpage><lpage>690</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kozlova T.V., Makeyeva I.M., Doroshina V.Y., Bokareva S.I., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Козлова Т.В., Макеева И.М., Дорошина В.Ю., Бокарева С.И.</copyright-holder><copyright-holder xml:lang="en">Kozlova T.V., Makeyeva I.M., Doroshina V.Y., Bokareva S.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/968">https://www.rpcardio.online/jour/article/view/968</self-uri><abstract><p>Details of the management of patients receiving oral anticoagulants (vitamin K antagonists) for a long time and needed in dental treatment are discussed. Assessment of bleeding and thromboembolism risk in the perioperative continuation or termination of warfarin therapy is shown. Potential of the local hemostatic agents is specified. Modifications of the patient dental health card are offered to prevent complications associated with blood clotting disorders.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются особенности ведения больных, длительное время получающих лечение оральными антикоагулянтами (антивитаминами К) и нуждающихся в стоматологических вмешательствах. Дается оценка риска кровоточивости и возникновения тромбоэмболизма при периоперационном продолжении или прекращении приема варфарина. Уточняются возможности местных гемостатических препаратов. Предлагаются дополнения в карту здоровья стоматологического пациента с целью предупреждения осложнений, связанных с нарушениями свертывания крови.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>варфарин</kwd><kwd>инвазивные стоматологические процедуры</kwd><kwd>кровотечение</kwd><kwd>тромбоэмболизм</kwd><kwd>тромбофилия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>warfarin</kwd><kwd>invasive dental procedures</kwd><kwd>bleeding</kwd><kwd>thromboembolism</kwd><kwd>thrombophilia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Young K.M. Laboratory medicine: Yesterday, Today, Tomorrow. Vet Clin Path 2005; 34(1):76.</mixed-citation><mixed-citation xml:lang="en">Young K.M. Laboratory medicine: Yesterday, Today, Tomorrow. Vet Clin Path 2005; 34(1):76.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Singer D.E, Albers G., Dalen J.E. et al. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl):546S–592S.</mixed-citation><mixed-citation xml:lang="en">Singer D.E, Albers G., Dalen J.E. et al. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl):546S–592S.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kearon C., Kahn S.R., Agnelli G. et al. Antithrombotic therapy for venous thromboembolic disease:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl): 454S–545S.</mixed-citation><mixed-citation xml:lang="en">Kearon C., Kahn S.R., Agnelli G. et al. Antithrombotic therapy for venous thromboembolic disease:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl): 454S–545S.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lim W., Wang M., Crowther M., Douketis J. The management of anticoagulated patients requiring dental extraction: a cross-sectional survey of oral and maxillofacial surgeons and hematologists. J Thromb Haemost 2007; 5(10):2157-9.</mixed-citation><mixed-citation xml:lang="en">Lim W., Wang M., Crowther M., Douketis J. The management of anticoagulated patients requiring dental extraction: a cross-sectional survey of oral and maxillofacial surgeons and hematologists. J Thromb Haemost 2007; 5(10):2157-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Linnebur S.A., Ellis S., Astroth J.D. Educational practices regarding anticoagulation and dental procedures in US dental schools. J Dent Educ 2007;71(2):296-303.</mixed-citation><mixed-citation xml:lang="en">Linnebur S.A., Ellis S., Astroth J.D. Educational practices regarding anticoagulation and dental procedures in US dental schools. J Dent Educ 2007;71(2):296-303.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ward B.B., SmithM.H.Dentoalveolar procedures forthe anticoagulated patient: literature recommendations versus current practice. J Oral Maxillofac Surg 2007; 65(8):1454-60.</mixed-citation><mixed-citation xml:lang="en">Ward B.B., SmithM.H.Dentoalveolar procedures forthe anticoagulated patient: literature recommendations versus current practice. J Oral Maxillofac Surg 2007; 65(8):1454-60.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Douketis J.D. Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians. Thromb Res 2002; 108(1):3-13.</mixed-citation><mixed-citation xml:lang="en">Douketis J.D. Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians. Thromb Res 2002; 108(1):3-13.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dugdale M., Smith R.M. The patient with bleeding problems. Dent Clin North Am 1983;27(2): 271-88.</mixed-citation><mixed-citation xml:lang="en">Dugdale M., Smith R.M. The patient with bleeding problems. Dent Clin North Am 1983;27(2): 271-88.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Patton L.L., Ship J.A. Treatment of patients with bleeding disorders. Dent Clin North Am 1994;38(3): 465-82.</mixed-citation><mixed-citation xml:lang="en">Patton L.L., Ship J.A. Treatment of patients with bleeding disorders. Dent Clin North Am 1994;38(3): 465-82.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Douketis J.D., Berger P.B., Dunn A.S. et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl):299S–339S.</mixed-citation><mixed-citation xml:lang="en">Douketis J.D., Berger P.B., Dunn A.S. et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6 Suppl):299S–339S.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Perry D.J., Noakes T.J., Helliwell P.S. Guidelines for the management of patients on oral anticoagulants requiring dental surgery. British Dental Journal 2007; 203(7): 389-393.</mixed-citation><mixed-citation xml:lang="en">Perry D.J., Noakes T.J., Helliwell P.S. Guidelines for the management of patients on oral anticoagulants requiring dental surgery. British Dental Journal 2007; 203(7): 389-393.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ziffer A.M., Scopp I.W., Beck J. et al. Profound bleeding after dental extractions during dicumarol therapy. N Engl J Med 1957; 256(8): 351-353.</mixed-citation><mixed-citation xml:lang="en">Ziffer A.M., Scopp I.W., Beck J. et al. Profound bleeding after dental extractions during dicumarol therapy. N Engl J Med 1957; 256(8): 351-353.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Mubarak S., Rass M.A.,Alsuwyed A. et al. Thromboembolic risk and bleeding in patients maintaining or stoppingoral anticoagulanttherapyduringdental extraction.J ThrombHaemost2006;4(3):689-691.</mixed-citation><mixed-citation xml:lang="en">Al-Mubarak S., Rass M.A.,Alsuwyed A. et al. Thromboembolic risk and bleeding in patients maintaining or stoppingoral anticoagulanttherapyduringdental extraction.J ThrombHaemost2006;4(3):689-691.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Randall C. Surgical management of the primary care dental patient on warfarin. Dent Update 2005; 32(7): 414-416, 419-420, 423-424.</mixed-citation><mixed-citation xml:lang="en">Randall C. Surgical management of the primary care dental patient on warfarin. Dent Update 2005; 32(7): 414-416, 419-420, 423-424.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wahl M J. Dental surgery in anticoagulated patients. Arch Intern Med 1998; 158(15): 1610-1616.</mixed-citation><mixed-citation xml:lang="en">Wahl M J. Dental surgery in anticoagulated patients. Arch Intern Med 1998; 158(15): 1610-1616.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Devani P., Lavery K.M., Howell C.J. Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary? Br J Oral Maxillofac Surg 1998; 36(2): 107-111.</mixed-citation><mixed-citation xml:lang="en">Devani P., Lavery K.M., Howell C.J. Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary? Br J Oral Maxillofac Surg 1998; 36(2): 107-111.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Campbell J.H., Alvarado F., Murray R.A. Anticoagulation and minor oral surgery: should the anticoagulation regimen be altered? J Oral Maxillofac Surg 2000; 58(2): 131-136.</mixed-citation><mixed-citation xml:lang="en">Campbell J.H., Alvarado F., Murray R.A. Anticoagulation and minor oral surgery: should the anticoagulation regimen be altered? J Oral Maxillofac Surg 2000; 58(2): 131-136.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Evans I.L., Sayers M.S., Gibbons A.J. et al. Can warfarin be continued during dental extraction? Re￾sults of a randomized controlled trial. Br J Oral Maxillofac Surg 2002; 40(3): 248-252.</mixed-citation><mixed-citation xml:lang="en">Evans I.L., Sayers M.S., Gibbons A.J. et al. Can warfarin be continued during dental extraction? Re￾sults of a randomized controlled trial. Br J Oral Maxillofac Surg 2002; 40(3): 248-252.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sacco R, Sacco M, Carpenedo M., Moia M. Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different INR targets. J Thromb Haemost 2006; 4(3): 688-689.</mixed-citation><mixed-citation xml:lang="en">Sacco R, Sacco M, Carpenedo M., Moia M. Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different INR targets. J Thromb Haemost 2006; 4(3): 688-689.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nematullah A, Alabousi A, Blanas N. et al. Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis. Tex Dent J 2009;126(12):1183-93.</mixed-citation><mixed-citation xml:lang="en">Nematullah A, Alabousi A, Blanas N. et al. Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis. Tex Dent J 2009;126(12):1183-93.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sindet-Pedersen S. Distribution of tranexamic acid to plasma and saliva after oral administration and mouth rinsing: a pharmacokinetic study. J Clin Pharmacol 1987; 27(12): 1005-1008.</mixed-citation><mixed-citation xml:lang="en">Sindet-Pedersen S. Distribution of tranexamic acid to plasma and saliva after oral administration and mouth rinsing: a pharmacokinetic study. J Clin Pharmacol 1987; 27(12): 1005-1008.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Blinder D., Manor Y., Martinowitz U. et al. Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88(2): 137-140.</mixed-citation><mixed-citation xml:lang="en">Blinder D., Manor Y., Martinowitz U. et al. Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88(2): 137-140.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Blinder D., Manor Y., Martinowitz U., Taicher S. Dental extractions in patients maintained on oral anticoagulant therapy: comparison of INR value with occurrence of postoperative bleeding. Int J Oral Maxillofac Surg 2001; 30(6): 518-521.</mixed-citation><mixed-citation xml:lang="en">Blinder D., Manor Y., Martinowitz U., Taicher S. Dental extractions in patients maintained on oral anticoagulant therapy: comparison of INR value with occurrence of postoperative bleeding. Int J Oral Maxillofac Surg 2001; 30(6): 518-521.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Zanon E., Martinelli F., Bacci C. et al. Safety of dental extraction among consecutive patients on oral anticoagulant treatment managed using a specific dental management protocol. Blood Coagul Fibrinolysis 2003; 14(1): 27-30.</mixed-citation><mixed-citation xml:lang="en">Zanon E., Martinelli F., Bacci C. et al. Safety of dental extraction among consecutive patients on oral anticoagulant treatment managed using a specific dental management protocol. Blood Coagul Fibrinolysis 2003; 14(1): 27-30.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sindet-Pedersen S., Ramstrom G., Bernvil S., Blomback M.Hemostatic effect oftranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. N Engl J Med 1989; 320(13): 840-843.</mixed-citation><mixed-citation xml:lang="en">Sindet-Pedersen S., Ramstrom G., Bernvil S., Blomback M.Hemostatic effect oftranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. N Engl J Med 1989; 320(13): 840-843.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Carter G., Goss A. Tranexamic acid mouthwash – a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions. Int J Oral Maxillofac Surg 2003; 32(5): 504-507.</mixed-citation><mixed-citation xml:lang="en">Carter G., Goss A. Tranexamic acid mouthwash – a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions. Int J Oral Maxillofac Surg 2003; 32(5): 504-507.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Stading J.A., Skrabal M.Z., FaulknerM.A. Seven cases ofinteraction betweenwarfarin and cyclooxygenase- 2 inhibitors. Am J Health Syst Pharm 2001;58(21):2076-2080.</mixed-citation><mixed-citation xml:lang="en">Stading J.A., Skrabal M.Z., FaulknerM.A. Seven cases ofinteraction betweenwarfarin and cyclooxygenase- 2 inhibitors. Am J Health Syst Pharm 2001;58(21):2076-2080.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gould F.K., Elliott T.S., Foweraker J. et al. Guidelines for the prevention of endocarditis: report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 2006; 57(6): 1035-1042.</mixed-citation><mixed-citation xml:lang="en">Gould F.K., Elliott T.S., Foweraker J. et al. Guidelines for the prevention of endocarditis: report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 2006; 57(6): 1035-1042.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia D.A., Regan S., Henault L.E. et al. Risk of Thromboembolism With Short-term Interruption of Warfarin Therapy. Arch Intern Med 2008;168(1):63-69</mixed-citation><mixed-citation xml:lang="en">Garcia D.A., Regan S., Henault L.E. et al. Risk of Thromboembolism With Short-term Interruption of Warfarin Therapy. Arch Intern Med 2008;168(1):63-69</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010; 29 [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010; 29 [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kovacs M.J., Kearon C., Rodger M. et al. Single-arm study of bridging therapy with low-molecularweight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation 2004;110(12):1658-1663</mixed-citation><mixed-citation xml:lang="en">Kovacs M.J., Kearon C., Rodger M. et al. Single-arm study of bridging therapy with low-molecularweight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation 2004;110(12):1658-1663</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Douketis J.D., Johnson J.A., Turpie A.G. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med 2004;164(12): 1319-1326.</mixed-citation><mixed-citation xml:lang="en">Douketis J.D., Johnson J.A., Turpie A.G. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med 2004;164(12): 1319-1326.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">McBane R.D., Wysokinski W.E., Daniels P.R. et al. Periprocedural Anticoagulation Management of Patients With Venous Thromboembolism. Arteriosclerosis, Thrombosis, and Vascular Biology 2010;30(3):442-448.</mixed-citation><mixed-citation xml:lang="en">McBane R.D., Wysokinski W.E., Daniels P.R. et al. Periprocedural Anticoagulation Management of Patients With Venous Thromboembolism. Arteriosclerosis, Thrombosis, and Vascular Biology 2010;30(3):442-448.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hong C.H., Napeñas J.J., Brennan M.T. et al. Frequency of bleeding following invasive dental procedures in patients on low-molecular-weight heparin therapy. J Oral Maxillofac Surg. 2010;68(5): 975-9.</mixed-citation><mixed-citation xml:lang="en">Hong C.H., Napeñas J.J., Brennan M.T. et al. Frequency of bleeding following invasive dental procedures in patients on low-molecular-weight heparin therapy. J Oral Maxillofac Surg. 2010;68(5): 975-9.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy J., Twohig E., McWilliams S.R. Dentists' approach to patients on anti-platelet agents and warfarin: a survey of practice. J Ir Dent Assoc 2010;56(1):28-31.</mixed-citation><mixed-citation xml:lang="en">Murphy J., Twohig E., McWilliams S.R. Dentists' approach to patients on anti-platelet agents and warfarin: a survey of practice. J Ir Dent Assoc 2010;56(1):28-31.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mehra P., CottrellD.A., Bestgen S.C., Booth D.F. Management of heparin therapy in the high-risk, chronically anticoagulated oral surgery patient: a review and a proposed nomogram. J Oral Maxillofac Surg 2000;58(2):198-202.</mixed-citation><mixed-citation xml:lang="en">Mehra P., CottrellD.A., Bestgen S.C., Booth D.F. Management of heparin therapy in the high-risk, chronically anticoagulated oral surgery patient: a review and a proposed nomogram. J Oral Maxillofac Surg 2000;58(2):198-202.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
