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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2010-6-5-703-708</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-971</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>LONG-TERM THERAPY WITH ACETYLSALICYLIC ACID. HOW TO AVOID THE POSSIBLE COMPLICATIONS?</article-title><trans-title-group xml:lang="ru"><trans-title>ДЛИТЕЛЬНАЯ ТЕРАПИЯ АЦЕТИЛСАЛИЦИЛОВОЙ КИСЛОТОЙ. КАК ИЗБЕЖАТЬ ВОЗМОЖНЫХ ОСЛОЖНЕНИЙ?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жиров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhirov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., доцент кафедры скорой медицинской помощи</p><p>ст.н.с. отдела заболеваний миокарда и сердечной недостаточности </p><p>127473, Москва, ул. Делегатская, 20/1</p></bio><bio xml:lang="en"><p>Delegatskaya ul. 20/1, Moscow, 127473</p></bio><email xlink:type="simple">izhirov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет, &#13;
НИИ клинической кардиологии им. А.Л. Мясникова РКНПК Российского кардиологического научно-производственного комплекса</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2016</year></pub-date><volume>6</volume><issue>5</issue><fpage>703</fpage><lpage>708</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Zhirov I.V., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Жиров И.В.</copyright-holder><copyright-holder xml:lang="en">Zhirov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/971">https://www.rpcardio.online/jour/article/view/971</self-uri><abstract><p>Data about efficacy and safety of long-term therapy with acetylsalicylic acid in patients with cardiovascular diseases are presented. The main practical ways to reduce the possible gastrointestinal complications of the treatment are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены сведения, касающиеся эффективности и безопасности длительной терапии ацетилсалициловой кислотой пациентов с сердечно-сосудистыми заболеваниями. Показаны основные практические способы уменьшения возможных осложнений со стороны желудочно-кишечного тракта.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ацетилсалициловая кислота</kwd><kwd>сердечно-сосудистые события</kwd><kwd>безопасность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acetylsalicylic acid</kwd><kwd>cardiovascular events</kwd><kwd>safety</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chazov E.I. How to reduce mortality from cardiovascular diseases. Ter Arkh 2008;80(8):11-6. Russian (Чазов Е.И. 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