EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD)

Gender differences can significantly affect mortality in ST-segment elevation myocardial infarction (STEMI) in real practice. Aim. To evaluate the effect of gender on mortality in STEMI. Material and methods. Outcomes of in-hospital stage of treatment of 553 men (67.7%) and 263 women (32.3%) were analyzed in single-center retrospective study. Primary percutaneous coronary intervention (pPCI) and pharmacoinvasive strategy (PIS) were used in 160 (60.8%) and 103 (39.2%) women, respectively, as well as in 295 (53.3%) and 258 (46.7%) men, respectively. Patients with time ″primary medical contact (PMC) – balloon″ less than 60 min and ″symptom - PMC″ more than 6 hours were excluded. The majority of patients were in a time interval ″PMC - balloon″ about 120 minutes. Results. Mortality in women was significantly higher than this in men regardless of the reperfusion strategy – 15.3% in whole (18.1% at pPCI and 10.9% at PIS), and 3.1% in whole (5.1% at pPCI and 0.8% at FIS), respectively (p<0.001). The probability of lethal outcome in women was 4 times higher than this in men (odds ratio 4.4; 95% confidence interval 2.7-7.1). Conclusion. Clinical characteristics of the patients due to gender differences make a significant contribution to the course of STEMI. Women more often have severe complications and a worse in-hospital prognosis.

thrombolytic therapy, ST-segment elevation myocardial infarction, percutaneous coronary intervention, pharmacoinvasive strategy, gender

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