CHRONIC HEART FAILURE AND IRON-DEFICIENT ANEMIA
https://doi.org/10.20996/1819-6446-2007-3-1-9-14
Abstract
62 chronic heart failure (CHF) patients with iron-deficient anemia (IDA) were studied. Standard CHF therapy (angiotensin converting enzyme inhibitors, β-blockers, diuretics, cardiac glycosides) was accompanied with the correction of iron deficiency by intravenous injection of Venofer and subsequent Ferro-Folgamma prescription (average daily dose of iron 137,75±5mg). After treatment serum iron level increased by 95,5% and hemoglobin level – by 9,8%. Left ventricular ejection fraction increased by 32,2% and physical activity tolerance – by 47,6%. Before treatment 32 CHF patients with IDA (51,6%) had III functional class (FC) of CHF according to NYHA and 16 patients (25,8%) – IV FC. After treatment I FC was observed in 18 CHF patients (29%), II FC – in 26 patients and only 18 patients demonstrated III FC of CHF.
About the Authors
M. V. Melnik
Moscow Medical Academy named after I.M. Setchenov
Russian Federation
Russian Federation
A. M. Shilov
Moscow Medical Academy named after I.M. Setchenov
Russian Federation
Russian Federation
I. R. Kim
Moscow Medical Academy named after I.M. Setchenov
Russian Federation
Russian Federation
O. N. Retivykh
Moscow Medical Academy named after I.M. Setchenov
Russian Federation
Russian Federation
A. A. Saricheva
Moscow Medical Academy named after I.M. Setchenov
Russian Federation
Russian Federation
References
1. Арутюнов Г.П. Анемия у больных с ХСН. Журнал Сердечная Недостаточность. 2003; 4(5): 224-227.
2. Беленков Ю.Н. Классификация хронической сердечной недостаточности. Сердечная недостаточность. 2001; 2(6): 249-250.
3. Воробьев А.И. Руководство по гематологии. М. «Медицина». 1985; 2: 3-160.
4. Вуд Мари Э., Банн Пол А., Токарев Ю.Н., Бухин А.Е. Секреты гематологии и онкологии. Русский Медицинский журнал. 2002; №28.
5. Дворецкий Л.И. Клинические рекомендации по лечению больных железодефицитной анемии. Русский медицинский журнал. 2004; 12(14): 893-897.
6. Городецкий В.В., Годулян О.В. Железодефицитные состояния и железодефицитная анемия: лечение и диагностика. М. Медпрактика, 2004: 3-28.
7. Луговская С.А. Патогенез и диагностика анемий при хронических заболеваниях. Клиническая лабораторная диагностика. 1997; 112: 19-22.
8. Alexander M., Grumbach К., Remy L. et al. Congestive heart failure hospitalization and survival in Califon patterns according to race etnicity. Am. Heart J. 1999; 137: 919-927.
9. Burns D.L, Mascioli E.A., Bistrain B.R. Parenteral iron dextran: a review. Nutrition. 1995; 11: 163-168.
10. Chatterjee В., Nydegger U.E., Mohacsi P. Serum erythropoietin in heart failure patients treated with ACE-inhibitors or AT(1) antagonists. Eur.J. Heart Fail. 2000; 2: 393-398.
11. Iversen P.O., Woldbaek P.R., Tonnessen Т., et al. Decreased hematopoiesis in bone marrow of mice with congestive heart failure. Am J Physiol Regul. Integr. Comp. Physiol. 2002; 282: 166-172.
12. Kannel W. Epidemiology and prevention of cardiac failure. Framingham Study insights. Eur. Heart J., 1987; 8 Suppl.F: 23-26.
13. Kalra P.R., Bolger A.P., Francis D.P. et al. Effect of anemia on exercise tolerance in chronic heart failure. J. Cardiol. 2003; 91: 888- 891.
14. Miller L.W., Myssov E.D. Epidemiolodgy of heart failure. Cardiol. Clin. 2001; 19: 547-555.
15. Robinson B. Cost of anemia in the elderly. J Am Geriatr Soc. 2003; 51 (3 Suppl): S14-7.
16. Salahudeen AK., Oliver В., Bower J.D., et al. Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis. Kidney Int. 2001; 60: 1525-1531.
17. Silverberg D.S., Wexler D., Blum M. et al. The interact between Heart Failure, Renal Failure and Anemia; The Cardio-Renal Anemia Syndromte. Blood Purification. 2004; 22: 277-284.
18. Silverberg D.S., Wexler D., Sheps D. et al. The effect of correction of mild anemia in severe, resistant congestiv heart failure using subcutaneous erythropoietin and intravenous iron. A randomized controlled study. J. Am. Coll. Cardiol. 2001; 37: 1775-1780.
Review
For citations:
Melnik M.V., Shilov A.M., Kim I.R., Retivykh O.N., Saricheva A.A. CHRONIC HEART FAILURE AND IRON-DEFICIENT ANEMIA. Rational Pharmacotherapy in Cardiology. 2007;3(1):9-14. (In Russ.) https://doi.org/10.20996/1819-6446-2007-3-1-9-14
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