ПРИМЕНЕНИЕ ОМЕГА-3 ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ ДЛЯ ЛЕЧЕНИЯ БОЛЬНЫХ С АРИТМИЯМИ СЕРДЦА
https://doi.org/10.20996/1819-6446-2013-9-1-56-61
Аннотация
Имеются доказательства эффективного антиаритмического действия омега-3 полиненасыщенных жирных кислот, эйкозапентаеновой и докозагексаеновой кислот у больных с рецидивирующей фибрилляцией предсердий и желудочковыми аритмиями. При этом доказано положительное влияние на риск внезапной аритмической смерти и общую смертность больных, переносящих инфаркт миокарда, и больных, имеющих хроническую сердечную недостаточность.
Ключевые слова
Об авторах
А. О. Малыгин
Центральная клиническая больница с поликлиникой Управления делами Президента РФ, Москва
Россия
Малыгин Андрей Олегович — врач отделения нарушений ритма сердца
Россия
Малыгин Андрей Олегович — врач отделения нарушений ритма сердца
В. Л. Дощицин
Центральная клиническая больница с поликлиникой Управления делами Президента РФ, Москва
Россия
Дощицин Владимир Леонидович — доктор медицинских наук профессор, научный руководитель по терапии
Россия
Дощицин Владимир Леонидович — доктор медицинских наук профессор, научный руководитель по терапии
Список литературы
1. АСС/АНА/ESC 2006 Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 2006; 27: 2099–2140.
2. Lukomsky P. E., Bobkova B. I., Savenkov P. M. The Administration of Unsaturated Fatty Acids in Patients with Coronary Atherosclerosis. Cor et Vasa 1959; 1: 100.
3. Dyeberg J., Bang H.O., Stoffersen E. et al. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978; 2: 117–119.
4. Phillipson В. E., Rothrock D. W., Connor W. E. Reduction of plasma lipids, lipoproteins, and appoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 1985; 312: 1210–1216.
5. Goodnight S.H. The antithrombotic effects of fish oil. In: Simopoulos A.P., Kifer R.R., Martin R.T., eds. Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando, Fla: Academic Press; 1986; 135– 149.
6. Turner J., McLennan P. L., Abeywardena M. Y. Absence of coronary aortic atherosclerosis in rats having dietary lipid modified vulnerability to cardiac arrhythmias. Atherosclerosis 1990; 82:105–112.
7. Bang H. O., Dyerberg J., Hjorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand 1976; 200:69–73.
8. Hirai A., Terano T., Saito H. Clinical and epidemiological studies of eicosapentaenoic acid in Japan. In: Lands W.E.M., ed. Proceedings of the AOCS short course on polyunsaturated fatty acids and eicosanoids. Champaign, IL: American Oil Chemists' Society; 1987; 9–24.
9. Kromhout D., Bosschieter E.B., Coulander C. The inverse relation between fish consumption and 20year mortality from coronary heart disease. N Engl J Med 1985; 312; 1205–09.
10. Leaf A., Jorgensen M. B., Jacobs A. K. Do fish oils prevent restenosis after coronary angioplasty? Circulation 1994; 90:2248–2257.
11. Coker S. J., Parratt J. R., Ledingham I. M. Evidence that thromboxane contributes to ventricular fibrillation induced by reperfusion of the ischaemic myocardium. J Mol Cell Cardiol 1982; 14:483–5.
12. Coker S.J., Parratt J.R. AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion induced arrhythmias in anaesthetized greyhounds. Br J Pharmacol 1985; 86:259–264.
13. Chamock J.S., McLennan P.L., Abeywardena M.Y. Dietary modulation of lipid metabolism and mechanical performance of the heart. Mol Cell Biochem 1992; 116:19–25.
14. Charnock J. S. Lipids and cardiac arrhythmias. Prog Lipid Res 1994; 33:355–85.
15. Spector A. A., Yorek M. A. Membrane lipid composition and cellular function. J Lipid Res 1985; 26:1015– 35.
16. Charnock J. S., Abeywardena M. Y., McLennan P. L. Diet and cardiacarrhythmia: Effects of lipids on age related changes in myocardial function in the rat. Ann Nutr Metab 1985; 29:306.
17. Hallaq H., Smith T. W., Leaf A. Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids. Proc Natl Acad Sci U.S.A. 1992; 89:1760–4.
18. McLennan P. L. Relative effects of dietary saturated, monounsaturated and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 1993; 57:207–12.
19. McLennan P. L., Abeywardena M. Y., Charnock J. S. Reversal of arrhythmogenic effects of long term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids. Am J Clin Nutr 1990; 51:53–58.
20. Kurien V. A., Oliver M. F. A metabolic cause for arrhythmias during acute myocardial hypoxia. Lancet 1970; 1(7651): 813–815.
21. Van derVusse G. J., Glatz J.F.C., Stam H.C.G. Fatty acid homeostasis in the ormoxicand ischemic heart. Physiol Rev 1992; 72:881–940.
22. Oliver M. F., Opie L. H. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 1994; 343:155–158.
23. Manning A. S., Hearse D. J. Reperfusion induced arrhythmias: mechanisms and prevention. J Mol Cell Cardiol 1984; 16:497–518.
24. Billman G. E., Leaf A. The effects of omega-3 fatty acids on ventricular fibrillation induced by myocardial ischemia. In: Pownall, H. J. and Spector, A. A. eds. Omega-3 Fatty Acids in Nutrition, Vascular Biology and Medicine. Houston, TX: American Heart Association; 1994: 159–165.
25. Opie L. H. The Heart. Physiology and Metabolism. New York: Raven Press; 1991.
26. Weber P. C. Fish oil fatty acids and cardiovascular function: Epidemiology and biochemical mechanisms. Biochem Soc Trans 1990; 18:1045–1049.
27. Kinsella J. E., Lokesh B., Stone R. A. Dietary polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms. Am J Clin Nutr 1990; 52:1–28.
28. Hallaq H., Sellmayer A., Smith, T. W., Leaf A. Protective effects of eicosapentaenoic acid on ouabain toxicity in neonatal rat cardiac myocytes. Proc Natl Acad Sci USA 1990; 87:7834–7838.
29. Boland L., Drzewiecki M. Polyunsaturated fatty acid modulation of voltagegated ion channels. Cell Biohem Biophys 2008; 52: 59–84.
30. Kinoshita I., Itoh K., Nishida-Nakai M. Antiarrhythmic effects of eicosapentaenoic acid during myocardial infarctionenhanced cardiac micro-somal (Ca2/-Mg2/)-ATPase activity. Jap J Circ 1994; 58:903–912.
31. Knapp H. R. Physiological and biochemical effects of fatty acids in man. In: Sinclair A., Gibson R. eds. Essential Fatty Acids and Eicosanoids. Champaign, IL: AOCS Publications; 1993: 330–333.
32. Dai J., Williams S. A., Ziegelhoffer A. Structure-activity relationship of the effect of cis-unsaturated fatty acids and heart sarcolemmal phospholipase D activity. Prostaglandins. Leukotrienes. Essent Fatty Acids 1995; 52:167–171.
33. Abeywardena M. Y., McLennan P. L., Charnock J. S. Role of eicosanoids in dietary fat modification of cardiac arrhythmia and ventricular fibrillation. In: Sinclair A., Gibson R. eds. Essential Fatty Acids and Eicosanoids. Champaign, IL: AOCS Publications; 1993: 257–261.
34. Pepe S., McLennan P. L. Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. J Nutr 1996; 126:34–42.
35. McLennan P. L., Abeywardena M. Y., Charnock J. S. Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion. Am Heart J 1988; 116:709–717.
36. McLennan P.L., Bridle T.M., Abey wardena M.Y., Charnok J.S., Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am Heart J 1992;123(6):1555–61.
37. McLennan P L., Abeywardena M. Y., Charnock J. S. Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation. Can J Physiol Pharmacol 1985; 63:1411–1417.
38. McLennan P. L., Dallimore J. A. Dietary canola oil modifies myocardial fatty acids and inhibits cardiac arrhythmias in rats. J Nutr 1995; 125:1003–1009.
39. McLennan P., Howe P., Abeywardena M. Y., et al. The cardiovascular protective role of docosahexaenoic acid. Eur J Pharmacol 1996; 300:83–89.
40. Pepe S., McLennan P. L. Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. J Nutr 1996; 126:34–42.
41. Kang J. X., Leaf A. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc Natl Acad Sc USA 1994; 91:9886–9890.
42. Leaf A. Omega-3 fatty acids and prevention of ventricular fibrillation. Prostaglandins. Leukotrienes. Essent Fatty Acids 1995; 52:197–198.
43. Bang H. O., et al. The composition of the Eskimo food in Northwestern Greenland. Am J Clin Nutr 1980; 33: 2657–2666.
44. Keys A. Seven countries. A multivariate analysis of diet and coronary heart disease. Cambridge, MA: Harvard University Press; 1980.
45. Kromhout D.t Bosschieter E. B., Coulander C. The inverse relation between fish consumption and 20year mortality from coronary heart disease. N Engl J Med 1985; 312:1205–1209.
46. Shekelle R. В., Missel, L., Paul O. Fish consumption and mortality from coronary heart disease. Lancet 1985; 313:820.
47. Burr M.L. Reflections on the diet and reinfarction trial (DART) Eur Heart J 2001; 3 (Suppl D): D75–78.
48. GISSI-Prevenzione Investigators Dietary supplementationwith n-3 polyunsaturated fatty acids and vitamin E aftermyocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354 (9177): 447–455.
49. GISSI-HF investigators. Effect of n-3 PUFA in patients with chronic heart failure: a randomized, doubleblind, pacebo-controlled trial. Lancet 2008; 372:1223–1130.
50. Carlo L., Bianconi L. Fatty acids for the prevention of atrial fibrillation after coronary bypass surgery: a randomized, controlled trial. J Am Coll Cardiol 2005; 45:1723–1728.
51. Panov A.V., Tatarskiy B.A., Gordeev M.L., et al. Omega-3 polyunsaturated fatty acids in atrial fibrillation prevention after surgical myocardial revascularization. Rational Pharmacother. Card. 2008; (3):
52. –30. Russian (Панов А.В, Татарский Б.А., Гордеев М.Л., и др. Омега-3-ПНЖК в профилактике фибрилляции предсердий после хирургической реваскуляризации миокарда. Рациональная Фармакотерапия в Кардиологии 2008; (3): 26–30).
53. Nodari S., Manerba A., Madureri A., et al. Effects of polyunsaturated fatty acids n-3 in the prophylaxis of atrial fibrillation relapses after external electric cardioversion. Eur. Heart J., 2006; 27, 887.
54. Antonchenko I.V., Tatarskiy B.A., Rodionov B.A., et al. The use of omega-3 polyunsaturated fatty acids in the treatment of paroxysmal atrial fibrillation. Vestnik Aritmologii 2009; 53: 5–11. Russian (Антонченко И.В., Татарский Б.А., Родионов B.А., и др. Использование омега-3 полиненасыщенных жирных кислот при лечении пароксизмальных форм фибрилляции предсердий. Вестник Аритмологии 2009; 53: 5–11).
55. Nifontov E.M., Shikhaliev D.R., Bogachev M.I., et al. Antiarrhythmic activity of omega-3 polyunsaturated fatty acids in patients with stable ischemic heart disease and ventricular rhythm disturbances. Kardiologiia 2010;50(12):4–9. Russian (Нифонтов Е. М., Шихалиев Д.Р., Красичков А.С., и др. Антиаритмическая эффективность омега-3 полиненасыщенных жирных кислот у больных стабильной ишемической болезнью сердца с желудочковыми нарушениями ритма. Кардиология 2010; 50(12): 4–9).
Рецензия
Для цитирования:
Малыгин А.О., Дощицин В.Л. ПРИМЕНЕНИЕ ОМЕГА-3 ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ ДЛЯ ЛЕЧЕНИЯ БОЛЬНЫХ С АРИТМИЯМИ СЕРДЦА. Рациональная Фармакотерапия в Кардиологии. 2013;9(1):56-61. https://doi.org/10.20996/1819-6446-2013-9-1-56-61
For citation:
Malygin A.O., Doshchitsin V.L. THE USE OF OMEGA-3 FATTY ACIDS FOR THE TREATMENT OF PATIENTS WITH CARDIAC ARRHYTHMIAS. Rational Pharmacotherapy in Cardiology. 2013;9(1):56-61. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-1-56-61
Просмотров:
971
Послать статью по эл. почте 