COMORBIDITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A ROLE OF CARDIOVASCULAR DISORDERS
https://doi.org/10.20996/1819-6446-2009-5-4-9-16
Abstract
Aim. To study prevalence and features of cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure) in patients with chronic obstructive pulmonary disease (COPD).
Material and methods. 233 patients with COPD (229 men, 4 women; 55,3±0,6 y.o.) were examined. General clinical examination, including body mass index calculation, 6-min walk test, blood analysis, electrocardiography, echocardiography, investigation of respiratory function, pulsoxymetry was carried out. Cardiac Infarction Injury Score (CIIS) index was also evaluated.
Results. COPD is associated with arterial hypertension in 62,2% of cases, ischemic heart disease - 27%, carotid atherosclerosis - 43,6%, chronic heart failure in 23,6% of cases. Risk factors of ischemic heart disease in COPD patients include: age, COPD severity, bronchial obstruction severity (decrease of forced expiratory volume), systemic inflammation (high level of C-reactive protein). Patients with severe and very severe COPD had CIIS index >20 1,8 times more often than patients with moderate COPD. Significant correlation of CIIS index with pulmonary hypertension (r=0,21, p<0,05), end-diastolic dimension of right ventricle (r=0,24, p<0,05) and left ventricle (r=0,33, p<0,05), left ventricle ejection fraction (r=-0,40, p<0,01) was found.
Conclusion. COPD is associated with cardiovascular diseases. CIIS index can help to detect previous myocardial infarction in COPD patients.
About the Authors
N. A. Karoli
Saratov State Medical University
Russian Federation
Russian Federation
Chair of Hospital Therapy
Bolshaya Kazachia ul. 112, Saratov, 410012
A. P. Rebrov
Saratov State Medical University
Russian Federation
Russian Federation
Chair of Hospital Therapy
Bolshaya Kazachia ul. 112, Saratov, 410012
References
1. Hansell A.L., Walk J.A., Soriano J.B. What do chronic obstructive pulmonary disease patients die from? A multiple case coding analysis. Eur Respir J 2003;22(5):809-14.
2. Almagro P., Calbo E., Ochoa de Echagüen A. et al. Mortality after hospitalization for COPD. Chest 2002;121(5):1441–8.
3. Engstrom G., Lind P., Hedblad B. et al. Lung function and cardiovascular risk: relationship with inflammation-sensitive plasma proteins. Circulation 2002;106(20):2555-60.
4. Antonelli Incalzi A.R., Fuso L., De Rosa M. et al. Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur Respir J 1997;10(12):2794–800.
5. Sin D.D., Man S.F. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003;107(11):1514-9.
6. Rosenberg A.L., Watts C. Patients readmitted to ICUs*: a systematic review of risk factors and outcomes. Chest 2000;118(2):492–502.
7. Higgins M., Keller J.B., Wagenknecht L.E. et al. Pulmonary function and cardiovascular risk factor relationship in black and in white young men and women. The CARDIA Study. Chest 1991;99(2):315-22.
8. Jousilahti P., Vartiainen E., Tuomilehto J., Puska P. Symptoms of chronic bronchitis and the risk of coronary disease. Lancet 1996;348(9027):567-72.
9. Celli B.R., MacNee W.; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004;23(6):932-46.
10. Richardson K., Engel G., Yamazaki T. et al. Electrocardiographic damage scores and cardiovascular mortality. Am Heart J 2005;149(3):458-63.
11. van Domburg R.T., Klootwijk P., Deckers J.W. et al. The Cardiac Infarction Injury Score as a predictor for long-term mortality in survivors of a myocardial infarction. Eur Heart J 1998;19(7):1034-41.
12. Dekker J.M., Schouten E.G., Kromhout D. et al. The Cardiac Infarction Injury Score and coronary heart disease in middle-aged and elderly men: the Zutphen Study. J Clin Epidemiol 1995;48(6):833-40.
Review
For citations:
Karoli N.A., Rebrov A.P. COMORBIDITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A ROLE OF CARDIOVASCULAR DISORDERS. Rational Pharmacotherapy in Cardiology. 2009;5(4):9-16. https://doi.org/10.20996/1819-6446-2009-5-4-9-16
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