ANGIOTENSIN CONVERTING ENZYME INHIBITORS: DECREASE IN HEART REMODELING AND IMPROVEMENT IN FUNCTION OF ENDOTHELIUM IN PATIENTS WITH ARTERIAL HYPERTENSION
https://doi.org/10.20996/1819-6446-2006-2-4-12-17
Abstract
Aim. To estimate an effect of enalapril, angiotensin converting enzyme (ACE) inhibitor , on left ventricular hypertrophy and endothelium function in patients with arterial hypertension (HT). Material and methods. 41 patients with HT of I-III grade were included into the study. A part of patients received enalapril in an average daily doze of 10 mg. Parameters of microcirculatory reactivity and computer electrocardiogram analysis according to original technique were studied. Results. Microcirculatory indices showed that 6 month enalapril treatment resulted in significant improvement of disturbed function of vascular endothelium. Reduction of left ventricular hypertrophy also was demonstrated. Conclusion. ACE inhibitors should be widely recommended in hypertensive patients due to their vascular and heart remodeling positive effects.
About the Authors
K. Yu. NikolaevRussian Federation
G. I. Lifshits
Russian Federation
A. A. Nikolaeva
Russian Federation
I. M. Gicheva
Russian Federation
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Review
For citations:
Nikolaev K.Yu., Lifshits G.I., Nikolaeva A.A., Gicheva I.M. ANGIOTENSIN CONVERTING ENZYME INHIBITORS: DECREASE IN HEART REMODELING AND IMPROVEMENT IN FUNCTION OF ENDOTHELIUM IN PATIENTS WITH ARTERIAL HYPERTENSION. Rational Pharmacotherapy in Cardiology. 2006;2(4):12-17. (In Russ.) https://doi.org/10.20996/1819-6446-2006-2-4-12-17
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