EFFICACY AND SAFETY OF GINKGO BILOBA IN ELDERLY PATIENTS WITH CONTROLLED ARTERIAL HYPERTENSION AND CIRCULATORY ENCEPHALOPATHY
https://doi.org/10.20996/1819-6446-2008-4-4-59-64
Abstract
Aim. To study effects of Ginkgo biloba based drug (Memoplant, Dr Willar Schwabe, Germany) on haemorheological and clinical status in elderly patients with circulatory encephalopathy and controlled arterial hypertension.
Material and methods. 80 patients (>60 y.o.) were involved in the study. Patients were randomized (3:1) on Memoplant (240 mg/daily) treatment group and control group. Duration of observation was 16 weeks. The changes of neurological complaints, neuropsychological and life quality test results were estimated during the study. The rheological indicators (blood, plasma and erythrocyte suspension viscosity; aggregative activity and plasticity of erythrocytes) also were studied.
Results. Reduction (by 50-90%) of neurological complaints (headache, giddiness, tinnitus, unsteadiness walking) were founded in patients receiving Memoplant. Cognitive abilities according to mental status scale, frontal tests battery, 5 words test, watch drawing test and quality of a life according to QOLI-NS scale improved in patients treated with Memoplant. Decrease of blood viscosity (by 19,3%, р<0,01) , erythrocytes rigidity index (by 15,6%, р<0,05) and erythrocyte aggregation (degree of aggregation by 45,6%; average aggregate size by 25,9%, р<0,05) > <0,05) was observed. Tissue oxygen supply was increased by 23,3% (р<0,05) in comparison with initial state. Changes of haemorheological indicators were not founded in control group.
Conclusion. Memoplant increases brain oxygenation due to improvement of microcirculatory blood flow.
About the Authors
V. V. Jakusevich
Yaroslavl State Medical Academy, Respublikanskaya ul., 108, Yaroslavl, 150000 Russia
Russian Federation
Russian Federation
N. V. Semenova
Yaroslavl Regional Clinical Hospital of Wars Veterans
Russian Federation
Russian Federation
I. A. Tihomirova
Biorheological Laboratory of Yaroslavl State Pedagogical University named after K.D. Ushinsky
Russian Federation
Russian Federation
A. V. Muravyov
Biorheological Laboratory of Yaroslavl State Pedagogical University named after K.D. Ushinsky
Russian Federation
Russian Federation
S. V. Lychenko
Yaroslavl State Medical Academy, Respublikanskaya ul., 108, Yaroslavl, 150000 Russia
Russian Federation
Russian Federation
References
1. Haguenauer J.P., Cantenot F., Koskas H., Pierart H. Treatment of equilibrium disorders with Ginkgo biloba extract. A multicenter double-blind drug vs. placebo study. Presse Med 1986;15(31):1569-72.
2. Holstein N. Ginkgo extract helps patients suffering from tinnitus. Review of the literature shows: tinnitus decreases. MMW Fortschr Med 2000;142(47):46.
3. Claussen C.F., Kirtane M.V. Randomisierte Doppelblindstudie zur Wirkung von Extractum Ginkgo biloba bei Schwindel und Gangunsicherheit des älteren Menschen. In: Claussen CF (Hrsg) Presyvertigo, Presbyataxie, Presbytinnitus. Berlin: Springer Verlag; 1985. P. 103-115.
4. Hamann K. F. Physical treatment of vestibular vertigo in relation with Ginkgo biloba extract. Therapiewoche 1985;35:4586-90.
5. Heide W., Adlung B., Hörr R., Kömpf D. Schwindel und Nystagmus bei zentral-vestibulären Ischämien: eine Placebo-kontrollierte Therapiestudie mit Ginkgo-biloba-Extrakt EGb 761®. Aktuelle Neurologie 1998;25(Suppl 3):S94.
6. Le Bars P.L., Katz M.M., Berman N. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 1997;278(16):1327–32.
7. Mancini M., Agozzino B., Bompani R. Clinical and therapeutic effects of Ginkgo biloba extract (GBE) compared to placebo in the treatment of patients affected by senile psychorganic dementia on an arteriosclerotic basic. Gazzetta Medica Italiana Archivio per le Scienze Mediche 1993;152(3):69-80.
8. Haase J., Halama P., Hörr R. Effectiveness of brief infusions with Ginkgo biloba Special Extract EGb 761 in dementia of the vascular and Alzheimer type. Z Gerontol Geriatr 1996;29(4):302-9.
9. Kanowski S., Hoerr R. Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial. Pharmacopsychiatry 2003;36(6):297- 303.
10. Kanowski S., Herrmann W.M., Stephan K. et al. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996;29(2):47-56.
11. Maurer K., Ihl R., Dierks T., Frölich L. Clinical efficacy of Ginkgo biloba special extract Egb 761 in dementia of the Alzheimer type. J Psychiatr Res 1997;31:645-55.
12. Schneider Ls, DeKosky S.T., Farlow M.R. et al. A randomized, doubleblind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Current Alzheimer Research 2005;2(5):541-51.
13. Weitbrecht W.U., Jansen W. Ginkgo biloba extract in the treatment of primary degenerative dementia. Placebo controlled double-blind and comparative study. Fortschr Med 1986;104:199-202.
14. Kennedy D.O., Scholey A.B., Wesnes K.A. The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology 2000;151:416-23.
15. Scholey A.B., Kennedy D.O. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand. Human Psychopharmacology 2002;17:35-44.
16. Subhan Z., Hindmarch I. The psychopharmacological effects of Ginkgo biloba extract in normal healthy volunteers. Int J Clin Pharmacol Res 1984;4(2):89-93.
17. Blume J., Kieser M., Hölscher U. Placebo-controlled double-blind study of the effectiveness of Ginkgo biloba special extract EGb 761 in trained patients with intermittent claudication. Vasa 1996;25(3):265-74.
18. Баев В.М., Шарапова Н.В., Судаков А.И., Шакиров Н.В. Изучение вязкопластических свойств при помощи регистрации и обработки переходных процессов крови. Мат. VI международной конференции «Гемореология и микроциркуляция». 10-13 июня 2007, Ярославль: ЯГПУ им. К.Д. Ушинского; 2007. С.38.
19. Ройтман Е.В., Фирсов Н.Н., Дементьева М.Г. и др. Термины, понятия и подходы к исследованиям реологии крови в клинике. Тромбоз, гемостаз и реология 2000;3(3):5-12.
20. Тихомирова И.А., Муравьев А.В, Михайличенко Л.А., Голубкова Е.В. Анализ взаимосвязи электрофоретической подвижности и агрегационных свойств эритроцитов человека. Физиология человека 2006;32(6):133-5.
21. Михайличенко Л.А., Александров П.Н. Модификация установки с камерой Горяева для измерения электрофоретической подвижности форменных элементов крови и других клеток. В: Методы исследования микроциркуляции. Уфа: БашГМУ; 2004. С. 292–300.
22. Михайлова С.Г., Семенова Н.Е., Якусевич В.В., Тихомирова И.А. Влияние мемопланта на реологические свойства эритроцитов: исследование in vitro. Мат. VI международной конференции «Гемореология и микроциркуляция». 10-13 июня 2007, Ярославль: ЯГПУ им. К.Д. Ушинского; 2007. С.45.
23. Hsu J.P., Lin S.-H., Tseng S. Effect of cell membrane structure of human erythrocyte on its electrophoresis. Colloids and Surfaces B: Biointerfaces 2003; 32(3): 203–212.
24. Козинец Г.И., Погорелов В.М., Шмаров Д.А., Боев С.Ф., Сазонов В.В. Клетки крови – современные технологии их анализа. М: Триада–фарм; 2002.
25. Харамоненко С.С., Ракитянская А.А. Электрофорез клеток крови в норме и патологии. Минск: Беларусь, 1974.
26. Фирсов Н.Н., Коротаева Т.В., Вышлова М.А.. Классификация тяжести гемореологических расстройств. Реологич Исслед в мед 2000;2:136-141.
27. Жирнов В.В., Гавий В.Н., Калашникова Л.Е. Действие малых доз ионизирующего излучения на поверхностный потенциал клеток крови на фоне модификаторов аденилатциклазного каскада. Возможные токсикологические аспекты. Современные проблемы токсикологии 2002;4:50-54.
28. Якусевич В.В., Семёнова Н.Е., Тихомирова И.А., Петроченко А.С. Клинические и гемореологические эффекты препарата Ginkgo Biloba – мемоплант у пожилых пациентов с ДЭП. Мат. VI международной конференции «Гемореология и микроциркуляция». 10- 13 июня 2007, Ярославль: ЯГПУ им. К.Д. Ушинского; 2007. С. 41.
Review
For citations:
Jakusevich V.V., Semenova N.V., Tihomirova I.A., Muravyov A.V., Lychenko S.V. EFFICACY AND SAFETY OF GINKGO BILOBA IN ELDERLY PATIENTS WITH CONTROLLED ARTERIAL HYPERTENSION AND CIRCULATORY ENCEPHALOPATHY. Rational Pharmacotherapy in Cardiology. 2008;4(4):59-64. (In Russ.) https://doi.org/10.20996/1819-6446-2008-4-4-59-64
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