ФАРМАКОТЕРАПИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ У ПОЖИЛЫХ ПАЦИЕНТОВ: ФОКУС НА ВОСЬМИДЕСЯТИЛЕТНИХ
https://doi.org/10.20996/1819-6446-2016-12-2-210-219
Аннотация
В статье обсуждается фармакотерапия артериальной гипертензии у лиц пожилого возраста, приводятся российские и международные рекомендации по целевому уровню артериального давления и препаратам выбора у данной категории пациентов. Обсуждаются вопросы эффективности и безопасности фармакотерапии у лиц в возрасте 80 лет и старше.
Об авторах
Е. А. Ушкалова
Российский университет дружбы народов, Москва
Россия
Россия
Ушкалова Елена Андреевна – доктор медицинских наук, профессор кафедры общей и клинической фармакологии РУДН
О. Н. Ткачева
Российский геронтологический научно-клинический центр, Москва
Россия
Россия
Ткачева Ольга Николаевна – доктор медицинских наук, профессор, директор РГНКЦ
Н. К. Рунихина
Российский геронтологический научно-клинический центр, Москва
Россия
Россия
Рунихина Надежда Константиновна – доктор медицинских наук, зам. директора РГНКЦ
Н. А. Чухарева
Научный центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова, Москва
Россия
Россия
Чухарева Наталья Александровна – младший научный сотрудник терапевтического отделения НИИ акушерства и гинекологии имени В.И. Кулакова
А. Ю. Бевз
Российский геронтологический научно-клинический центр, Москва
Россия
Россия
Бевз Алина Юрьевна – старший научный сотрудник РГНКЦ
Список литературы
1. Bramlage, P., Hasford, J. Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment—a review. Cardiovasc Diabetol 2009; 8 (18): 2840-8.
2. Mozaffarian, D., Benjamin, E.J., Go, A.S., et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 2015 131 (4): e29-322.
3. Pimenta E, Oparil S. Management of hypertension in the elderly. Nat Rev Cardiol 2012;9:286-96.
4. Kaiser EA, Lotze U, Schäfer HH. Increasing complexity: which drug class to choose for treatment of hypertension in the elderly? Clin Interv Aging 2014;9:459-75.
5. Aronow WS, Fleg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2011;123(21):2434-506.
6. Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-13.
7. Angeli F, Reboldi G, Verdecchia P. Hypertension and the J-curve phenomenon: implications for tight blood pressure control. Hypertens Res 2013; 36: 109-11.
8. Buford TW. Hypertension and aging. Ageing Res Rev 2016; 26:96-111.
9. Turnbull F, Neal B, Ninomiya T, et al. Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials. BMJ 2008;336(7653):1121-3.
10. Musini VM, Tejani AM, Bassett K, et al. Pharmacotherapy for hypertension in the elderly. Cochrane Database Syst Rev 2009;4:CD00028.
11. Briasoulis A, Agarwal V, Tousoulis D, Stefanadis C. Effects of antihypertensive treatment in patients over 65 years of age: a meta-analysis of randomised controlled studies. Heart 2014;100(4):317-23.
12. Xue H, Lu Z, Tang WL, et al. First-line drugs inhibiting the renin angiotensin system versus other firstline antihypertensive drug classes for hypertension. Cochrane Database Syst Rev 2015;1:CD008170.
13. Diagnosis and treatment of hypertension. Russian recommendation (4th revision). Arterial'nye gipertenzii 2010; (3): 5-26. In Russian (Диагностика и лечение артериальной гипертонии. Российские рекомендации (4-й пересмотр). Артериальные гипертензии 2010; (3): 5-26).
14. Mancia G, Fagard R, Narkiewicz K, et al. ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34(28):2159-219.
15. Houle SK, Padwal R, Tsuyuki RT. The 2012-2013 Canadian Hypertension Education Program (CHEP) guidelines for pharmacists: An update. Can Pharm J (Ott) 2013;146(3):146-50.
16. National Clinical Guideline Centre (UK). Hypertension: The Clinical Management of Primary Hypertension in Adults: Update of Clinical Guidelines 18 and 34. London: Royal College of Physicians (UK); 2011 Aug.
17. Weber MA, Schiffrin EL, White WB. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Clin Hypertens (Greenwich) 2014;16(1):14-26.
18. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311(5):507-20.
19. Gueyffier F, Bulpitt C, Boissel J-P, et al. Antihypertensive drugs in very old people: a sub-group metaanalysis of randomised controlled trials. Lancet 1999;353:793-6.
20. Beckett NS, Peters R, Fletcher AE, et al., HYVET Study Group. Treatment of hypertension in patients 80 years of age or older.N Engl J Med 2008; 358(18):1887-98.
21. Butt DA, Harvey PJ. Benefits and risks of antihypertensive medications in the elderly. J Intern Med 2015;278(6):599-626.
22. Benetos A, Rossignol P, Cherubini A, et al. Polypharmacy in the Aging Patient: Management of Hypertension in Octogenarians. JAMA 2015;314(2):170-80.
23. Warwick J, Falaschetti E, Rockwood K, et al. No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Med 2015;13:78.
24. Bejan-Angoulvant T, Saadatian-Elahi M, Wright JM, et al. Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials. J Hypertens 2010;28(7):1366-72.
25. Rastas S, Pirttila T, Viramo P, et al. Association between blood pressure and survival over 9 years in a general population aged 85 and older. J Am Geriatr Soc 2006;54:912-8.
26. Oates DJ, Berlowitz DR, Glickman ME, et al. Blood pressure and survival in the oldest old. J Am Geriatr Soc 2007;55:383-8.
27. Benetos A, Buatois S, Salvi P, et al. Blood pressure and pulse wave velocity values in the institutionalized elderly aged 80 and over: baseline of the PARTAGE study. J Hypertens 2010;28(1):41-50.
28. Benetos A, Labat C, Rossignol P, et al. Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents: The PARTAGE Study. JAMA Intern Med 2015;175(6):989-95.
29. Schall P, Wehling M. Treatment of arterial hypertension in the very elderly: a meta-analysis of clinical trials. Arzneimittelforschung 2011;61(4):221-8.
30. Wiysonge CS, Bradley HA, Volmink J, et al. Beta-blockers for hypertension. Cochrane Database Syst Rev 2012;11:CD002003.
31. Kuyper LM, Khan NA. Atenolol vs nonatenolol β-blockers for the treatment of hypertension: a metaanalysis. Can J Cardiol 2014;30(5 Suppl):S47-53.
32. Levi Marpillat N, Macquin-Mavier Tropeano A, et al. Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J Hypertens 2013;31(6):1073-82.
33. Zhuang S, Li J, Wang X, et al. Renin-angiotensin system-targeting antihypertensive drugs and risk of vascular cognitive impairment: A meta-analysis. Neurosci Lett 2016;615:1-8.
34. Tully PJ, Hanon O, Cosh S, Tzourio C. Diuretic antihypertensive drugs and incident dementia risk: a systematic review, meta-analysis and meta-regression of prospective studies. J Hypertens. 2016 Feb 17. [Epub ahead of print]
35. Parsons C, Murad MH, Andersen S, et al. The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: a meta-analysis. Future Cardiol 2016;12(2):237-48.
36. Peters R, Booth A, Peters J. A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderly. J Hypertens 2014;32(10):1945-57.
37. van der Wardt V, Logan P, Conroy S, et al. Antihypertensive treatment in people with dementia. Am Med Dir Assoc 2014;15(9):620-9.
38. Welsh TJ, Gladman JR, Gordon AL. The treatment of hypertension in people with dementia: a systematic review of observational studies. BMC Geriatr 2014;14:19.
39. Xin W, Lin Z, Li X. Orthostatic hypotension and the risk of congestive heart failure: a meta-analysis of prospective cohort studies. PLoS One 2013;8(5):e63169.
40. Veronese N, De Rui M, Bolzetta F, et al. Orthostatic Changes in Blood Pressure and Mortality in the Elderly: The Pro.V.A Study. Am J Hypertens 2015;28(10):1248-56.
41. Canney M, O'Connell MD, Murphy CM, et al. Single Agent Antihypertensive Therapy and Orthostatic Blood Pressure Behaviour in Older Adults Using Beat-to-Beat Measurements: The Irish Longitudinal Study on Ageing. PLoS One 2016;11(1):e0146156.
42. Zia A, Kamaruzzaman SB, Tan MP. Blood pressure lowering therapy in older people: Does it really cause postural hypotension or falls? Postgrad Med 2015;127(2):186-93.
43. Gribbin J, Hubbard R, Gladman J, et al. Risk of falls associated with antihypertensive medication: selfcontrolled case series. Pharmacoepidemiol Drug Saf 2011;20(8):879-84.
44. Butt DA, Mamdani M, Austin PC, et al. The risk of falls on initiation of antihypertensive drugs in the elderly. Osteoporos Int 2013;24(10):2649-57.
45. Lipsitz LA, Habtemariam D, Gagnon M, et al. Reexamining the Effect of Antihypertensive Medications on Falls in Old Age. Hypertension 2015;66(1):183-9.
46. Zang G. Antihypertensive drugs and the risk of fall injuries: a systematic review and meta-analysis. J Int Med Res 2013;41(5):1408-17.
47. Park H, Satoh H, Miki A, et al. Medications associated with falls in older people: systematic review of publications from a recent 5-year period. Eur J Clin Pharmacol 2015;71(12):1429-40.
48. Butt DA, Mamdani M, Austin PC, et al. The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med 2012;172(22):1739-44.
49. Corrao G, Mazzola P, Monzio Compagnoni M, et al. Antihypertensive Medications, Loop Diuretics, and Risk of Hip Fracture in the Elderly: A Population-Based Cohort Study of 81,617 Italian Patients Newly Treated Between 2005 and 2009. Drugs Aging 2015;32(11):927-36.
50. Callisaya ML, Sharman JE, Close J, et al. Greater daily defined dose of antihypertensive medication increases the risk of falls in older people a population-based study. J Am Geriatr Soc 2014; 62: 1527- 33.
51. Ham AC, Swart KM, Enneman AW et al. Medication-related fall incidents in an older, ambulant population: the B-PROOF study. Drugs Aging 2014; 31: 917-27.
52. Tinetti ME, Han L, Lee DSH et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med 2014; 174: 588-95.
53. Aung K, Htay T. Thiazide diuretics and the risk of hip fracture. Cochrane Database Syst Rev 2011;(10):CD005185.
54. Wiens M, Etminan M, Gill SS, Takkouche B. Effects of antihypertensive drug treatments on fracture outcomes: a meta-analysis of observational studies. J Intern Med 2006;260(4):350-62.
55. Peters R, Beckett N, Burch L et al. The effect of treatment based on a diuretic (indapamide) +/ACE inhibitor (perindopril) on fractures in the Hypertension in the Very Elderly Trial (HYVET). Age Ageing 2010; 39: 609-16.
56. Ruths S, Bakken MS, Ranhoff A, et al. Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study. BMC Geriatr 2015;15:153.
57. Khatib R, Yusuf S, Barzilay JI, et al. Impact of lifestyle factors on fracture risk in older patients with cardiovascular disease: a prospective cohort study of 26,335 individuals from 40 countries. Age Ageing 2014;43(5):629-35.
58. El-Bikai R, Tahir MR, Tremblay J, et al. Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals. J Hypertens 2015;33(4):727-35.
59. Arrabal-Martín M, González-Torres S, Cano-García MC. Treatment with hydrochlorothiazide and alendronate in patients with stones and bone mineral density loss. Evolution of bone metabolism and calciuria with medical treatment Arch Esp Urol 2016;69(1):9-18.
60. Solomon DH, Ruppert K, Zhao Z, et al. Bone mineral density changes among women initiating blood pressure lowering drugs: a SWAN cohort study. Osteoporos Int 2016;27(3):1181-9.
61. Masunari N, Fujiwara S, Nakata Y, et al. Effect of angiotensin converting enzyme inhibitor and benzodiazepine intake on bone loss in older Japanese. Hiroshima J Med Sci 2008;57(1):17-25.
62. Lynn H, Kwok T, Wong SY, et al. Angiotensin converting enzyme inhibitor use is associated with higher bone mineral density in elderly Chinese. Bone 2006;38(4):584-8.
Рецензия
Для цитирования:
Ушкалова Е.А., Ткачева О.Н., Рунихина Н.К., Чухарева Н.А., Бевз А.Ю. ФАРМАКОТЕРАПИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ У ПОЖИЛЫХ ПАЦИЕНТОВ: ФОКУС НА ВОСЬМИДЕСЯТИЛЕТНИХ. Рациональная Фармакотерапия в Кардиологии. 2016;12(2):210-219. https://doi.org/10.20996/1819-6446-2016-12-2-210-219
For citation:
Ushkalova E.A., Tkacheva O.N., Runikhina N.K., Chukhareva N.A., Bevz A.Yu. PHARMACOTHERAPY OF ARTERIAL HYPERTENSION IN ELDERLY PATIENTS: FOCUS ON OCTOGENARIANS. Rational Pharmacotherapy in Cardiology. 2016;12(2):210-219. (In Russ.) https://doi.org/10.20996/1819-6446-2016-12-2-210-219
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